Proteomic analysis of uropathogenic Escherichia coli

Phillip Cash

Research output: Contribution to journalLiterature review

8 Citations (Scopus)

Abstract

Urinary tract infections (UTIs) are among the most common of bacterial infections in humans. Although a number of Gram-negative bacteria can cause UTIs, most cases are due to infection by uropathogenic E. coli (UPEC). Genomic studies have shown that UPEC encode a number of specialized activities that allow the bacteria to initiate and maintain infections in the environment of the urinary tract. Proteomic analyses have complemented the genomic data and have documented differential patterns of protein synthesis for bacteria growing ex vivo in human urine or recovered directly from the urinary tracts of infected mice. These
studies provide valuable insights into the molecular basis of UPEC pathogenesis and have aided the identification of putative vaccine targets. Despite the substantial progress that has been achieved, many future challenges remain in the application of proteomics to provide a comprehensive view of bacterial pathogenesis in both acute and chronic UTIs.
Original languageEnglish
Pages (from-to)43-58
Number of pages16
JournalExpert Review of Proteomics
Volume11
Issue number1
DOIs
Publication statusPublished - Feb 2014

Keywords

  • proteomics
  • Escherichia-coli
  • bacterial pathogenesis
  • urinary tract infections
  • uropathogenic Escherichia

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