Quantitative assessment of cerebral connectivity deficiency and cognitive impairment in children with prenatal alcohol exposure

Lin Gao (Corresponding Author), Celso Grebogi, Ying-Cheng Lai, Julia Stephen, Tongsheng Zhang, Yuanli Li, Haipeng Ren, Dichen Li, Jue Wang, Bjoern Schelter, Linda Sommerlade

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Abstract

It is common sense that alcohol consumption during pregnancy would cause cognitive impairment in children. However, recent works suggested the risk of drinking during pregnancy may have been exaggerated. It is a critical issue to determine whether and up to which amount the consumption of alcohol will affect the cognitive development of children. We evaluate time-varying functional connectivity using magnetoencephalogram data from somatosensory evoked response experiments for nineteen teenage subjects with prenatal alcohol exposure and twenty-one healthy control teenage subjects using a new time-varying connectivity approach, combining renormalised partial directed coherence with state space modelling. Children exposed to alcohol prenatally are at risk of developing a Fetal Alcohol Spectrum Disorder (FASD) characterized by cerebral connectivity deficiency and impaired cognitive abilities. Through a comparison study of teenage subjects exposed to alcohol prenatally with healthy control subjects, we establish that the inter-hemispheric connectivity is deficient for the former, which may lead to disruption in cortical inter-hemispheric connectivity and deficits in higher order cognitive functions as measured by e.g., IQ test. We provide quantitative evidence that the disruption is correlated with cognitive deficits. These findings could lead to a novel, highly sensitive biomarker for FASD, and support a recommendation of no safe amount of alcohol consumption during pregnancy.
Original languageEnglish
Article number041101
JournalChaos
Volume29
Issue number4
Early online date2 Apr 2019
DOIs
Publication statusPublished - Apr 2019

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impairment
Alcohol
Connectivity
alcohols
Alcohols
pregnancy
Pregnancy
Disorder
Time-varying
State-space Modeling
disorders
drinking
Children
biomarkers
Biomarkers
recommendations
Recommendations
Higher Order
Partial
Evaluate

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Applied Mathematics
  • Statistical and Nonlinear Physics
  • Mathematical Physics

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Quantitative assessment of cerebral connectivity deficiency and cognitive impairment in children with prenatal alcohol exposure. / Gao, Lin (Corresponding Author); Grebogi, Celso; Lai, Ying-Cheng; Stephen, Julia ; Zhang, Tongsheng ; Li, Yuanli; Ren, Haipeng; Li, Dichen; Wang, Jue; Schelter, Bjoern; Sommerlade, Linda.

In: Chaos, Vol. 29, No. 4, 041101 , 04.2019.

Research output: Contribution to journalArticle

Gao, Lin ; Grebogi, Celso ; Lai, Ying-Cheng ; Stephen, Julia ; Zhang, Tongsheng ; Li, Yuanli ; Ren, Haipeng ; Li, Dichen ; Wang, Jue ; Schelter, Bjoern ; Sommerlade, Linda. / Quantitative assessment of cerebral connectivity deficiency and cognitive impairment in children with prenatal alcohol exposure. In: Chaos. 2019 ; Vol. 29, No. 4.
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abstract = "It is common sense that alcohol consumption during pregnancy would cause cognitive impairment in children. However, recent works suggested the risk of drinking during pregnancy may have been exaggerated. It is a critical issue to determine whether and up to which amount the consumption of alcohol will affect the cognitive development of children. We evaluate time-varying functional connectivity using magnetoencephalogram data from somatosensory evoked response experiments for nineteen teenage subjects with prenatal alcohol exposure and twenty-one healthy control teenage subjects using a new time-varying connectivity approach, combining renormalised partial directed coherence with state space modelling. Children exposed to alcohol prenatally are at risk of developing a Fetal Alcohol Spectrum Disorder (FASD) characterized by cerebral connectivity deficiency and impaired cognitive abilities. Through a comparison study of teenage subjects exposed to alcohol prenatally with healthy control subjects, we establish that the inter-hemispheric connectivity is deficient for the former, which may lead to disruption in cortical inter-hemispheric connectivity and deficits in higher order cognitive functions as measured by e.g., IQ test. We provide quantitative evidence that the disruption is correlated with cognitive deficits. These findings could lead to a novel, highly sensitive biomarker for FASD, and support a recommendation of no safe amount of alcohol consumption during pregnancy.",
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