Rapid and reversible impairment of episodic memory by a high-fat diet in mice

Fiona H McLean (Corresponding Author), Christine Grant, Amanda C Morris, Graham W Horgan, Alex Polanski, Kevin Allan, Fiona M Campbell, Rosamund Langston, Lynda Williams

Research output: Contribution to journalArticle

8 Citations (Scopus)
7 Downloads (Pure)

Abstract

Alzheimer’s disease is a leading cause of morbidity and mortality with no cure and only limited treatment available. Obesity and type 2 diabetes are positively associated with the development of premature cognitive decline and Alzheimer’s disease, linking diet with these conditions. Here we demonstrate that in mice episodic memory, together with spatial and contextual associative memory, is compromised after only one day of high-fat diet. However, object memory remains intact. This shows not only a more rapid effect than previously reported but also that more complex memories are at higher risk of being compromised by a high-fat diet. In addition, we show that these memory deficits are rapidly reversed by switching mice from a high-fat diet back to a low-fat diet. These findings have important implications for the contribution of nutrition to the development of cognitive decline and Alzheimer’s disease.
Original languageEnglish
Article number11976
Number of pages9
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 10 Aug 2018

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Episodic Memory
High Fat Diet
Alzheimer Disease
Fat-Restricted Diet
Memory Disorders
Type 2 Diabetes Mellitus
Obesity
Diet
Morbidity
Mortality
Cognitive Dysfunction
Therapeutics

Keywords

  • high-fat diet
  • obesity
  • mice
  • episodic memory
  • Alzheimer's disease

Cite this

Rapid and reversible impairment of episodic memory by a high-fat diet in mice. / McLean, Fiona H (Corresponding Author); Grant, Christine; Morris, Amanda C; Horgan, Graham W; Polanski, Alex ; Allan, Kevin; Campbell, Fiona M; Langston, Rosamund; Williams, Lynda.

In: Scientific Reports, Vol. 8, 11976, 10.08.2018.

Research output: Contribution to journalArticle

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