We would like to comment on the systematic review by Li et al.1 The use of steroid hormones in the first trimester is a serious issue, as organogenesis takes place at this time and therefore there is the possibility of harm not only from congenital anomalies, but also long‐term, and even inter‐generational effects. Anyone investigating the use of steroid hormones in the first trimester should remember the diethylstilbestrol legacy of devastating harm. Estrogen (C18H24O2) and diethylstilbestrol (C18H20O2) have similar molecular compositions, but their effects are poles apart.
|Pages (from-to)||i-vi, 1173-1310|
|Number of pages||2|
|Journal||BJOG: An International Journal of Obstetrics and Gynaecology|
|Early online date||28 May 2020|
|Publication status||Published - 1 Sep 2020|