Re: Effect of progestogen for women with threatened miscarriage: a systematic review and meta-analysis

Adam J. Devall, Ioannis D. Gallos, Yakoub Khalaf, Ben W.J. Mol, Jackie Ross, Andrew Shennan, Andrew W. Horne, Rachel Small, Mariëtte Goddijn, Madelon van Wely, Mary D. Stephenson, Ole B. Christiansen, Jan J. Brosens, Phil Bennett, Raj Rai, Lesley Regan, Siobhan Quenby, Arri Coomarasamy*

*Corresponding author for this work

Research output: Contribution to journalLetter

1 Citation (Scopus)

Abstract

ir,

We would like to comment on the systematic review by Li et al.1 The use of steroid hormones in the first trimester is a serious issue, as organogenesis takes place at this time and therefore there is the possibility of harm not only from congenital anomalies, but also long‐term, and even inter‐generational effects. Anyone investigating the use of steroid hormones in the first trimester should remember the diethylstilbestrol legacy of devastating harm. Estrogen (C18H24O2) and diethylstilbestrol (C18H20O2) have similar molecular compositions, but their effects are poles apart.
Original languageEnglish
Pages (from-to)i-vi, 1173-1310
Number of pages2
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume127
Issue number10
Early online date28 May 2020
DOIs
Publication statusPublished - 1 Sep 2020

Fingerprint Dive into the research topics of 'Re: Effect of progestogen for women with threatened miscarriage: a systematic review and meta-analysis'. Together they form a unique fingerprint.

  • Cite this

    Devall, A. J., Gallos, I. D., Khalaf, Y., Mol, B. W. J., Ross, J., Shennan, A., Horne, A. W., Small, R., Goddijn, M., van Wely, M., Stephenson, M. D., Christiansen, O. B., Brosens, J. J., Bennett, P., Rai, R., Regan, L., Quenby, S., & Coomarasamy, A. (2020). Re: Effect of progestogen for women with threatened miscarriage: a systematic review and meta-analysis. BJOG: An International Journal of Obstetrics and Gynaecology, 127(10), i-vi, 1173-1310. https://doi.org/10.1111/1471-0528.16358