Re: Effect of progestogen for women with threatened miscarriage: a systematic review and meta-analysis

Adam J. Devall; Ioannis D. Gallos; Yakoub Khalaf; Ben W.J. Mol; Jackie Ross; Andrew Shennan; Andrew W. Horne; Rachel Small; Mariëtte Goddijn; Madelon van Wely; Mary D. Stephenson; Ole B. Christiansen; Jan J. Brosens; Phil Bennett; Raj Rai; Lesley Regan; Siobhan Quenby; Arri Coomarasamy

doi:10.1111/1471-0528.16358

Re: Effect of progestogen for women with threatened miscarriage: a systematic review and meta-analysis

Adam J. Devall, Ioannis D. Gallos, Yakoub Khalaf, Ben W.J. Mol, Jackie Ross, Andrew Shennan, Andrew W. Horne, Rachel Small, Mariëtte Goddijn, Madelon van Wely, Mary D. Stephenson, Ole B. Christiansen, Jan J. Brosens, Phil Bennett, Raj Rai, Lesley Regan, Siobhan Quenby, Arri Coomarasamy^*

^*Corresponding author for this work

Applied Health Sciences

Research output: Contribution to journal › Letter › peer-review

4 Citations (Scopus)

Abstract

ir,

We would like to comment on the systematic review by Li et al.1 The use of steroid hormones in the first trimester is a serious issue, as organogenesis takes place at this time and therefore there is the possibility of harm not only from congenital anomalies, but also long‐term, and even inter‐generational effects. Anyone investigating the use of steroid hormones in the first trimester should remember the diethylstilbestrol legacy of devastating harm. Estrogen (C18H24O2) and diethylstilbestrol (C18H20O2) have similar molecular compositions, but their effects are poles apart.

Original language	English
Pages (from-to)	i-vi, 1173-1310
Number of pages	2
Journal	BJOG: An International Journal of Obstetrics and Gynaecology
Volume	127
Issue number	10
Early online date	28 May 2020
DOIs	https://doi.org/10.1111/1471-0528.16358
Publication status	Published - 1 Sep 2020

Keywords

Abortion, Spontaneous
Abortion, Threatened
Female
Humans
Pregnancy
Pregnancy Trimester, Second
Progestins

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Devall, A. J., Gallos, I. D., Khalaf, Y., Mol, B. W. J., Ross, J., Shennan, A., Horne, A. W., Small, R., Goddijn, M., van Wely, M., Stephenson, M. D., Christiansen, O. B., Brosens, J. J., Bennett, P., Rai, R., Regan, L., Quenby, S., & Coomarasamy, A. (2020). Re: Effect of progestogen for women with threatened miscarriage: a systematic review and meta-analysis. BJOG: An International Journal of Obstetrics and Gynaecology, 127(10), i-vi, 1173-1310. https://doi.org/10.1111/1471-0528.16358

Devall, AJ, Gallos, ID, Khalaf, Y, Mol, BWJ, Ross, J, Shennan, A, Horne, AW, Small, R, Goddijn, M, van Wely, M, Stephenson, MD, Christiansen, OB, Brosens, JJ, Bennett, P, Rai, R, Regan, L, Quenby, S & Coomarasamy, A 2020, 'Re: Effect of progestogen for women with threatened miscarriage: a systematic review and meta-analysis', BJOG: An International Journal of Obstetrics and Gynaecology, vol. 127, no. 10, pp. i-vi, 1173-1310. https://doi.org/10.1111/1471-0528.16358

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title = "Re: Effect of progestogen for women with threatened miscarriage: a systematic review and meta-analysis",

abstract = "ir,We would like to comment on the systematic review by Li et al.1 The use of steroid hormones in the first trimester is a serious issue, as organogenesis takes place at this time and therefore there is the possibility of harm not only from congenital anomalies, but also long‐term, and even inter‐generational effects. Anyone investigating the use of steroid hormones in the first trimester should remember the diethylstilbestrol legacy of devastating harm. Estrogen (C18H24O2) and diethylstilbestrol (C18H20O2) have similar molecular compositions, but their effects are poles apart. ",

keywords = "Abortion, Spontaneous, Abortion, Threatened, Female, Humans, Pregnancy, Pregnancy Trimester, Second, Progestins",

author = "Devall, {Adam J.} and Gallos, {Ioannis D.} and Yakoub Khalaf and Mol, {Ben W.J.} and Jackie Ross and Andrew Shennan and Horne, {Andrew W.} and Rachel Small and Mari{\"e}tte Goddijn and {van Wely}, Madelon and Stephenson, {Mary D.} and Christiansen, {Ole B.} and Brosens, {Jan J.} and Phil Bennett and Raj Rai and Lesley Regan and Siobhan Quenby and Arri Coomarasamy",

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doi = "10.1111/1471-0528.16358",

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T2 - Effect of progestogen for women with threatened miscarriage: a systematic review and meta-analysis

AU - Devall, Adam J.

AU - Gallos, Ioannis D.

AU - Khalaf, Yakoub

AU - Mol, Ben W.J.

AU - Ross, Jackie

AU - Shennan, Andrew

AU - Horne, Andrew W.

AU - Small, Rachel

AU - Goddijn, Mariëtte

AU - van Wely, Madelon

AU - Stephenson, Mary D.

AU - Christiansen, Ole B.

AU - Brosens, Jan J.

AU - Bennett, Phil

AU - Rai, Raj

AU - Regan, Lesley

AU - Quenby, Siobhan

AU - Coomarasamy, Arri

PY - 2020/9/1

Y1 - 2020/9/1

N2 - ir,We would like to comment on the systematic review by Li et al.1 The use of steroid hormones in the first trimester is a serious issue, as organogenesis takes place at this time and therefore there is the possibility of harm not only from congenital anomalies, but also long‐term, and even inter‐generational effects. Anyone investigating the use of steroid hormones in the first trimester should remember the diethylstilbestrol legacy of devastating harm. Estrogen (C18H24O2) and diethylstilbestrol (C18H20O2) have similar molecular compositions, but their effects are poles apart.

AB - ir,We would like to comment on the systematic review by Li et al.1 The use of steroid hormones in the first trimester is a serious issue, as organogenesis takes place at this time and therefore there is the possibility of harm not only from congenital anomalies, but also long‐term, and even inter‐generational effects. Anyone investigating the use of steroid hormones in the first trimester should remember the diethylstilbestrol legacy of devastating harm. Estrogen (C18H24O2) and diethylstilbestrol (C18H20O2) have similar molecular compositions, but their effects are poles apart.

KW - Abortion, Spontaneous

KW - Abortion, Threatened

KW - Female

KW - Humans

KW - Pregnancy

KW - Pregnancy Trimester, Second

KW - Progestins

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DO - 10.1111/1471-0528.16358

M3 - Letter

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AN - SCOPUS:85087295715

VL - 127

SP - i-vi, 1173-1310

JO - BJOG-An International Journal of Obstetrics and Gynaecology

JF - BJOG-An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

IS - 10

ER -

Re: Effect of progestogen for women with threatened miscarriage: a systematic review and meta-analysis

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