Recent advances in understanding the mechanism of action of bisphosphonates

Fraser Coxon, Keith Thompson, Michael John Rogers

Research output: Contribution to journalLiterature review

195 Citations (Scopus)

Abstract

Bisphosphonates (BPs) are widely used in the treatment of diseases associated with excessive osteoclast-mediated bone resorption, such as osteoporosis. Although several years ago the molecular target of the potent nitrogen-containing BPs (N-BPs) was identified as farnesyl diphosphate synthase, an enzyme in the mevalonate pathway, recent data have shed new light on the precise mechanism of inhibition and demonstrated that the acute-phase reaction, an adverse effect of N-BPs, is also caused by inhibition of this enzyme. In addition, the identification of BP analogues that inhibit different enzymes in the mevalonate pathway could lead to the development of novel inhibitors of bone resorption with potential applications in the treatment of bone disease.

Original languageEnglish
Pages (from-to)307-312
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume6
Issue number3
Early online date2 May 2006
DOIs
Publication statusPublished - Jun 2006

Keywords

  • nitrogen-containing bisphosphonates
  • RAB gernaylgeranyl transferase
  • farnesyl diphosphate synthase
  • acute-phase response
  • activation in-vitro
  • T-cell-activation
  • bone-resorption
  • mevalonate pathway
  • ATP analog
  • inhibition

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