Reducing multiple births in assisted reproduction technology

Siladitya Bhattacharya, Mohan S Kamath

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Multiple pregnancy, a complication of assisted reproduction technology, is associated with poorer maternal and perinatal outcomes. The primary reason behind this is the strategy of replacing more than one embryo during an assisted reproduction technology cycle to maximise pregnancy rates. The solution to this problem is to reduce the number of embryos transferred during in-vitro fertilisation. The transition from triple- to double-embryo transfer, which decreased the risk of triplets without compromising pregnancy rates, was easily implemented. The adoption of a single embryo transfer policy has been slow because of concerns about impaired pregnancy rates in a fresh assisted reproduction technology cycle. Widespread availability of effective cryopreservation programmes means that elective single embryo transfer, along with subsequent frozen embryo transfers, could provide a way forward. Any such strategy will need to consider couples' preferences and existing funding policies, both of which have a profound influence on decision making around embryo transfer.
Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalBest Practice & Research Clinical Obstetrics & Gynaecology
Volume28
Issue number2
Early online date4 Dec 2013
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Multiple Birth Offspring
Embryo Transfer
Pregnancy Rate
Single Embryo Transfer
Reproduction
Technology
Embryonic Structures
Multiple Pregnancy
Pregnancy Complications
Cryopreservation
Fertilization in Vitro
Decision Making
Mothers

Keywords

  • assisted reproduction technology
  • in-vitro fertilisation
  • multiple pregnancy
  • elective single embryo transfer

Cite this

Reducing multiple births in assisted reproduction technology. / Bhattacharya, Siladitya; Kamath, Mohan S.

In: Best Practice & Research Clinical Obstetrics & Gynaecology, Vol. 28, No. 2, 02.2014, p. 191-199.

Research output: Contribution to journalArticle

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