Reducing research waste by promoting informed responses to invitations to participate in clinical trials

Katie Gillies; Iain Chalmers; Paul Glasziou; Diana Elbourne; Jim Elliott; Shaun Treweek

doi:10.1186/s13063-019-3704-x

Reducing research waste by promoting informed responses to invitations to participate in clinical trials

Katie Gillies^*, Iain Chalmers, Paul Glasziou, Diana Elbourne, Jim Elliott, Shaun Treweek

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

8 Downloads (Pure)

Abstract

Poor recruitment to, and retention in, clinical trials is a source of research waste that could be reduced by more informed choices about participation. Barriers to effective recruitment and retention can be wide-ranging but relevance of the questions being addressed by trials and the outcomes that they are assessing are key for potential participants. Decisions about trial participation should be informed by general and trial-specific information and by considering broader assessments of 'informedness' and how they impact on both recruitment and retention. We suggest that more informed decisions about trial participation should encourage personally appropriate decisions, increase recruitment and retention, and reduce research waste and increase its value.

Original language	English
Article number	613
Number of pages	4
Journal	Trials
Volume	20
DOIs	https://doi.org/10.1186/s13063-019-3704-x
Publication status	Published - 28 Oct 2019

Keywords

Clinical trials
Informed choice
Recruitment
Research waste
Retention

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10.1186/s13063-019-3704-xLicence: CC BY

Gillies_et_al_Trials_Reducing_Research_VOR
© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Final published version, 498 KBLicence: CC BY

Cite this

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AU - Treweek, Shaun

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AB - Poor recruitment to, and retention in, clinical trials is a source of research waste that could be reduced by more informed choices about participation. Barriers to effective recruitment and retention can be wide-ranging but relevance of the questions being addressed by trials and the outcomes that they are assessing are key for potential participants. Decisions about trial participation should be informed by general and trial-specific information and by considering broader assessments of 'informedness' and how they impact on both recruitment and retention. We suggest that more informed decisions about trial participation should encourage personally appropriate decisions, increase recruitment and retention, and reduce research waste and increase its value.

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Reducing research waste by promoting informed responses to invitations to participate in clinical trials

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