Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study

Sean J Colloby, Michael J Firbank, Jiabao He, Alan J Thomas, Akshya Vasudev, Steve W Parry, John T O'Brien

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background

A limited number of studies have demonstrated changes in cerebral blood flow (CBF) in older individuals with depression, but there are considerable inconsistencies between studies.

Aims

To investigate changes in CBF using arterial spin labelling (ASL) magnetic resonance imaging (MRI) in people with late-life depression and in a similarly aged healthy control group.

Method

Sixty-eight participants (30 healthy individuals, 38 with depression) underwent ASL and T1-weighted MRI scanning. For each individual, regional estimates of separate grey and white matter CBF were obtained. Group differences in CBF and their associations with clinical features were examined.

Results

Significant increases were observed in white matter CBF in patients with depression relative to the control group (F1,65 = 9.7, P = 0.003). Grey matter CBF in lateral frontal, medial frontal, cingulate, central and parietal regions did not significantly differ between groups (F1,65¿2.1, P¿0.2). A significant correlation was found between white matter CBF and Montgomery–Åsberg Depression Rating Scale (MADRS) scores in depression (r' = –0.42, P = 0.03). Further analyses revealed that compared with controls, significant elevation of white matter CBF was apparent in participants whose depression was in remission (n = 21, MADRS¿10, P = 0.001) but not in those with current depression (n = 17, MADRS¿11, P = 0.80).

Conclusions

Findings suggest a compensatory response to white matter pathological change or a response to (or a predictor of) successful antidepressant treatment, perhaps by facilitating neurotransmission in specific circuits and so reducing depressive symptoms.
Original languageEnglish
Pages (from-to)150-155
Number of pages6
JournalBritish Journal of Psychiatry
Volume200
Issue number2
Early online date22 Dec 2011
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Cerebrovascular Circulation
Regional Blood Flow
Magnetic Resonance Spectroscopy
Depression
Magnetic Resonance Imaging
Control Groups
Parietal Lobe
Gyrus Cinguli
Synaptic Transmission
Antidepressive Agents
Healthy Volunteers

Cite this

Colloby, S. J., Firbank, M. J., He, J., Thomas, A. J., Vasudev, A., Parry, S. W., & O'Brien, J. T. (2012). Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study. British Journal of Psychiatry, 200(2), 150-155. https://doi.org/10.1192/bjp.bp.111.092387

Regional cerebral blood flow in late-life depression : arterial spin labelling magnetic resonance study. / Colloby, Sean J; Firbank, Michael J; He, Jiabao; Thomas, Alan J; Vasudev, Akshya; Parry, Steve W; O'Brien, John T.

In: British Journal of Psychiatry, Vol. 200, No. 2, 02.2012, p. 150-155.

Research output: Contribution to journalArticle

Colloby, Sean J ; Firbank, Michael J ; He, Jiabao ; Thomas, Alan J ; Vasudev, Akshya ; Parry, Steve W ; O'Brien, John T. / Regional cerebral blood flow in late-life depression : arterial spin labelling magnetic resonance study. In: British Journal of Psychiatry. 2012 ; Vol. 200, No. 2. pp. 150-155.
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abstract = "BackgroundA limited number of studies have demonstrated changes in cerebral blood flow (CBF) in older individuals with depression, but there are considerable inconsistencies between studies.AimsTo investigate changes in CBF using arterial spin labelling (ASL) magnetic resonance imaging (MRI) in people with late-life depression and in a similarly aged healthy control group.MethodSixty-eight participants (30 healthy individuals, 38 with depression) underwent ASL and T1-weighted MRI scanning. For each individual, regional estimates of separate grey and white matter CBF were obtained. Group differences in CBF and their associations with clinical features were examined.ResultsSignificant increases were observed in white matter CBF in patients with depression relative to the control group (F1,65 = 9.7, P = 0.003). Grey matter CBF in lateral frontal, medial frontal, cingulate, central and parietal regions did not significantly differ between groups (F1,65¿2.1, P¿0.2). A significant correlation was found between white matter CBF and Montgomery–{\AA}sberg Depression Rating Scale (MADRS) scores in depression (r' = –0.42, P = 0.03). Further analyses revealed that compared with controls, significant elevation of white matter CBF was apparent in participants whose depression was in remission (n = 21, MADRS¿10, P = 0.001) but not in those with current depression (n = 17, MADRS¿11, P = 0.80).ConclusionsFindings suggest a compensatory response to white matter pathological change or a response to (or a predictor of) successful antidepressant treatment, perhaps by facilitating neurotransmission in specific circuits and so reducing depressive symptoms.",
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AU - Colloby, Sean J

AU - Firbank, Michael J

AU - He, Jiabao

AU - Thomas, Alan J

AU - Vasudev, Akshya

AU - Parry, Steve W

AU - O'Brien, John T

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N2 - BackgroundA limited number of studies have demonstrated changes in cerebral blood flow (CBF) in older individuals with depression, but there are considerable inconsistencies between studies.AimsTo investigate changes in CBF using arterial spin labelling (ASL) magnetic resonance imaging (MRI) in people with late-life depression and in a similarly aged healthy control group.MethodSixty-eight participants (30 healthy individuals, 38 with depression) underwent ASL and T1-weighted MRI scanning. For each individual, regional estimates of separate grey and white matter CBF were obtained. Group differences in CBF and their associations with clinical features were examined.ResultsSignificant increases were observed in white matter CBF in patients with depression relative to the control group (F1,65 = 9.7, P = 0.003). Grey matter CBF in lateral frontal, medial frontal, cingulate, central and parietal regions did not significantly differ between groups (F1,65¿2.1, P¿0.2). A significant correlation was found between white matter CBF and Montgomery–Åsberg Depression Rating Scale (MADRS) scores in depression (r' = –0.42, P = 0.03). Further analyses revealed that compared with controls, significant elevation of white matter CBF was apparent in participants whose depression was in remission (n = 21, MADRS¿10, P = 0.001) but not in those with current depression (n = 17, MADRS¿11, P = 0.80).ConclusionsFindings suggest a compensatory response to white matter pathological change or a response to (or a predictor of) successful antidepressant treatment, perhaps by facilitating neurotransmission in specific circuits and so reducing depressive symptoms.

AB - BackgroundA limited number of studies have demonstrated changes in cerebral blood flow (CBF) in older individuals with depression, but there are considerable inconsistencies between studies.AimsTo investigate changes in CBF using arterial spin labelling (ASL) magnetic resonance imaging (MRI) in people with late-life depression and in a similarly aged healthy control group.MethodSixty-eight participants (30 healthy individuals, 38 with depression) underwent ASL and T1-weighted MRI scanning. For each individual, regional estimates of separate grey and white matter CBF were obtained. Group differences in CBF and their associations with clinical features were examined.ResultsSignificant increases were observed in white matter CBF in patients with depression relative to the control group (F1,65 = 9.7, P = 0.003). Grey matter CBF in lateral frontal, medial frontal, cingulate, central and parietal regions did not significantly differ between groups (F1,65¿2.1, P¿0.2). A significant correlation was found between white matter CBF and Montgomery–Åsberg Depression Rating Scale (MADRS) scores in depression (r' = –0.42, P = 0.03). Further analyses revealed that compared with controls, significant elevation of white matter CBF was apparent in participants whose depression was in remission (n = 21, MADRS¿10, P = 0.001) but not in those with current depression (n = 17, MADRS¿11, P = 0.80).ConclusionsFindings suggest a compensatory response to white matter pathological change or a response to (or a predictor of) successful antidepressant treatment, perhaps by facilitating neurotransmission in specific circuits and so reducing depressive symptoms.

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