Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1

Graeme Ian Murray, William Thomas Melvin, W. F. Greenlee, M. D. Burke

Research output: Contribution to journalEditorial

255 Citations (Scopus)

Abstract

Cytochrome P450 CYP1B1 is a relatively recently identified member of the CYP1 gene family. The purpose of this commentary is to review the regulatory mechanisms, metabolic specificity, and tissue-specific expression of this cytochrome P450 and to highlight its unique properties. The regulation of CYP1B1 involves a variety of both transcriptional and post-transcriptional mechanisms. CYP1B1 can metabolize a range of toxic and carcinogenic chemicals in vitro but in some cases with a unique stereoselectivity. Estradiol 4-hydroxylation appears to be a characteristic reaction catalyzed by human CYP1B1. However, there are considerable species differences regarding the regulation, metabolic specificity. and tissue-specific expression of this P450, In humans CYP1B1 is overexpressed in tumor cells, and this has important implications for tumor development and progression and the development of anticancer drugs specifically activated by CYP1B1.

Original languageEnglish
Pages (from-to)297-316
Number of pages19
JournalAnnual Review of Pharmacology and Toxicology
Volume41
DOIs
Publication statusPublished - 2001

Keywords

  • Ah receptor
  • drug metabolism
  • liver
  • tumor
  • ARYL-HYDROCARBON RECEPTOR
  • PRIMARY CONGENITAL GLAUCOMA
  • DNA ADDUCT FORMATION
  • BREAST-CANCER CELLS
  • 1B1 MESSENGER-RNA
  • HUMAN CYP1B1 GENE
  • P4501B1 CYP1B1
  • AH RECEPTOR
  • ADRENAL CYTOCHROME-P450
  • DIFFERENTIAL EXPRESSION

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