Relationship between -592A/C polymorphism of interleukin-10 (IL-10) gene and risk of early carotid atherosclerosis

Gaoqiang Xie; Phyo K Myint; Liancheng Zhao; Ying Li; Hao Wang; Lirong Liang; Yangfeng Wu

doi:10.1016/j.ijcard.2008.11.173

Relationship between -592A/C polymorphism of interleukin-10 (IL-10) gene and risk of early carotid atherosclerosis

Gaoqiang Xie, Phyo K Myint, Liancheng Zhao, Ying Li, Hao Wang, Lirong Liang, Yangfeng Wu

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

In a community-based study of 1295 Chinese men and women free of myocardial infarction and stroke we found that interleukin-10 (IL-10) −592C/C genotype was significantly associated with decreased risk of early carotid atherosclerosis compared to −592 A/A genotype. This observed association was significantly modified by known atherogenic risk factors namely smoking and obesity. In people with normal cholesterol (< 200 mg/L), −592 C/C genotype was also associated with lower levels of highly-sensitive C-reactive protein. Our findings generate an interesting hypothesis that the IL-10 −592C/C genotype may exert its protection against early atherosclerosis through anti-inflammatory pathways. Our results also confirm that gene–risk factor interaction plays an important role in pathogenesis of early atherosclerosis.

Original language	English
Pages (from-to)	102-104
Number of pages	3
Journal	International Journal of Cardiology
Volume	143
Issue number	1
DOIs	https://doi.org/10.1016/j.ijcard.2008.11.173
Publication status	Published - 6 Aug 2010

Keywords

adult
age of onset
aged
carotid artery diseases
female
humans
interleukin-10
male
middle aged
polymorphism, genetic
risk factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijcard.2008.11.173

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title = "Relationship between -592A/C polymorphism of interleukin-10 (IL-10) gene and risk of early carotid atherosclerosis",

abstract = "In a community-based study of 1295 Chinese men and women free of myocardial infarction and stroke we found that interleukin-10 (IL-10) −592C/C genotype was significantly associated with decreased risk of early carotid atherosclerosis compared to −592 A/A genotype. This observed association was significantly modified by known atherogenic risk factors namely smoking and obesity. In people with normal cholesterol (< 200 mg/L), −592 C/C genotype was also associated with lower levels of highly-sensitive C-reactive protein. Our findings generate an interesting hypothesis that the IL-10 −592C/C genotype may exert its protection against early atherosclerosis through anti-inflammatory pathways. Our results also confirm that gene–risk factor interaction plays an important role in pathogenesis of early atherosclerosis.",

keywords = "adult, age of onset, aged, carotid artery diseases, female, humans, interleukin-10, male, middle aged, polymorphism, genetic, risk factors",

author = "Gaoqiang Xie and Myint, {Phyo K} and Liancheng Zhao and Ying Li and Hao Wang and Lirong Liang and Yangfeng Wu",

year = "2010",

month = aug,

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doi = "10.1016/j.ijcard.2008.11.173",

language = "English",

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journal = "International Journal of Cardiology",

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T1 - Relationship between -592A/C polymorphism of interleukin-10 (IL-10) gene and risk of early carotid atherosclerosis

AU - Xie, Gaoqiang

AU - Myint, Phyo K

AU - Zhao, Liancheng

AU - Li, Ying

AU - Wang, Hao

AU - Liang, Lirong

AU - Wu, Yangfeng

PY - 2010/8/6

Y1 - 2010/8/6

N2 - In a community-based study of 1295 Chinese men and women free of myocardial infarction and stroke we found that interleukin-10 (IL-10) −592C/C genotype was significantly associated with decreased risk of early carotid atherosclerosis compared to −592 A/A genotype. This observed association was significantly modified by known atherogenic risk factors namely smoking and obesity. In people with normal cholesterol (< 200 mg/L), −592 C/C genotype was also associated with lower levels of highly-sensitive C-reactive protein. Our findings generate an interesting hypothesis that the IL-10 −592C/C genotype may exert its protection against early atherosclerosis through anti-inflammatory pathways. Our results also confirm that gene–risk factor interaction plays an important role in pathogenesis of early atherosclerosis.

AB - In a community-based study of 1295 Chinese men and women free of myocardial infarction and stroke we found that interleukin-10 (IL-10) −592C/C genotype was significantly associated with decreased risk of early carotid atherosclerosis compared to −592 A/A genotype. This observed association was significantly modified by known atherogenic risk factors namely smoking and obesity. In people with normal cholesterol (< 200 mg/L), −592 C/C genotype was also associated with lower levels of highly-sensitive C-reactive protein. Our findings generate an interesting hypothesis that the IL-10 −592C/C genotype may exert its protection against early atherosclerosis through anti-inflammatory pathways. Our results also confirm that gene–risk factor interaction plays an important role in pathogenesis of early atherosclerosis.

KW - adult

KW - age of onset

KW - aged

KW - carotid artery diseases

KW - female

KW - humans

KW - interleukin-10

KW - male

KW - middle aged

KW - polymorphism, genetic

KW - risk factors

U2 - 10.1016/j.ijcard.2008.11.173

DO - 10.1016/j.ijcard.2008.11.173

M3 - Article

C2 - 19118909

SN - 0167-5273

VL - 143

SP - 102

EP - 104

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 1

ER -

Relationship between -592A/C polymorphism of interleukin-10 (IL-10) gene and risk of early carotid atherosclerosis

Abstract

Keywords

UN SDGs

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