Relationship between -592A/C polymorphism of interleukin-10 (IL-10) gene and risk of early carotid atherosclerosis

Gaoqiang Xie, Phyo K Myint, Liancheng Zhao, Ying Li, Hao Wang, Lirong Liang, Yangfeng Wu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In a community-based study of 1295 Chinese men and women free of myocardial infarction and stroke we found that interleukin-10 (IL-10) −592C/C genotype was significantly associated with decreased risk of early carotid atherosclerosis compared to −592 A/A genotype. This observed association was significantly modified by known atherogenic risk factors namely smoking and obesity. In people with normal cholesterol (< 200 mg/L), −592 C/C genotype was also associated with lower levels of highly-sensitive C-reactive protein. Our findings generate an interesting hypothesis that the IL-10 −592C/C genotype may exert its protection against early atherosclerosis through anti-inflammatory pathways. Our results also confirm that gene–risk factor interaction plays an important role in pathogenesis of early atherosclerosis.
Original languageEnglish
Pages (from-to)102-104
Number of pages3
JournalInternational Journal of Cardiology
Volume143
Issue number1
DOIs
Publication statusPublished - 6 Aug 2010

Keywords

  • adult
  • age of onset
  • aged
  • carotid artery diseases
  • female
  • humans
  • interleukin-10
  • male
  • middle aged
  • polymorphism, genetic
  • risk factors

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