Resveratrol: Its biologic targets and functional activity

Shazib Pervaiz*, Andrea Lisa Holme

*Corresponding author for this work

Research output: Contribution to journalReview article

304 Citations (Scopus)

Abstract

The polyphenolic phytoalexin resveratrol (RSV) and its analogues have received tremendous attention over the past couple of decades because of a number of reports highlighting their benefits in vitro and in vivo in a variety of human disease models, including cardio- and neuroprotection, immune regulation, and cancer chemoprevention. These studies have underscored the high degree of diversity in terms of the signaling networks and cellular effector mechanisms that are affected by RSV. The activity of RSV has been linked to cell-surface receptors, membrane signaling pathways, intracellular signal-transduction machinery, nuclear receptors, gene transcription, and metabolic pathways. The promise shown by RSV has prompted heightened interest in studies aimed at translating these observations to clinical settings. In this review, we present a comprehensive account of the basic chemistry of RSV, its bioavailability, and its multiple intracellular target proteins and signaling pathways. Antioxid. Redox Signal. 11, 2851-2897.

Original languageEnglish
Pages (from-to)2851-2897
Number of pages47
JournalAntioxidants and Redox Signaling
Volume11
Issue number11
DOIs
Publication statusPublished - 1 Nov 2009

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