Reversible neural inactivation reveals hippocampal participation in several memory processes

G Riedel, J Micheau, A G M Lam, E V Roloff, S J Martin, H Bridge, L de Hoz, B Poeschel, J McCulloch, R G M Morris

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Abstract

Studies of patients and animals with brain lesions have implicated the hippocampal formation in spatial, declarative/relational and episodic types of memory. These and other types of memory consist of a series of interdependent but potentially dissociable memory processes-encoding, storage, consolidation and retrieval. To identify whether hippocampal activity contributes to these processes independently, we used a novel method of inactivating synaptic transmission using a water-soluble antagonist of AM PA/kainate glutamate receptors. Once calibrated using electrophysiological and two-deoxyglucose techniques in vivo, drug or vehicle was infused chronically or acutely into the dorsal hippocampus of rats at appropriate times during or after training in a water maze. Our findings indicate that hippocampal neural activity is necessary for both encoding and retrieval of spatial memory and for either trace consolidation or long-term storage.

Original languageEnglish
Pages (from-to)898-905
Number of pages8
JournalNature Neuroscience
Volume2
Publication statusPublished - 1999

Keywords

  • CEREBRAL GLUCOSE-UTILIZATION
  • RETROGRADE-AMNESIA
  • RECEPTOR ANTAGONISTS
  • WATER MAZE
  • AMPA
  • RAT
  • SYSTEMS
  • LESIONS
  • BRAIN
  • MODEL

Cite this

Riedel, G., Micheau, J., Lam, A. G. M., Roloff, E. V., Martin, S. J., Bridge, H., de Hoz, L., Poeschel, B., McCulloch, J., & Morris, R. G. M. (1999). Reversible neural inactivation reveals hippocampal participation in several memory processes. Nature Neuroscience, 2, 898-905.