Abstract
Studies of patients and animals with brain lesions have implicated the hippocampal formation in spatial, declarative/relational and episodic types of memory. These and other types of memory consist of a series of interdependent but potentially dissociable memory processes-encoding, storage, consolidation and retrieval. To identify whether hippocampal activity contributes to these processes independently, we used a novel method of inactivating synaptic transmission using a water-soluble antagonist of AM PA/kainate glutamate receptors. Once calibrated using electrophysiological and two-deoxyglucose techniques in vivo, drug or vehicle was infused chronically or acutely into the dorsal hippocampus of rats at appropriate times during or after training in a water maze. Our findings indicate that hippocampal neural activity is necessary for both encoding and retrieval of spatial memory and for either trace consolidation or long-term storage.
Original language | English |
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Pages (from-to) | 898-905 |
Number of pages | 8 |
Journal | Nature Neuroscience |
Volume | 2 |
Publication status | Published - 1999 |
Keywords
- CEREBRAL GLUCOSE-UTILIZATION
- RETROGRADE-AMNESIA
- RECEPTOR ANTAGONISTS
- WATER MAZE
- AMPA
- RAT
- SYSTEMS
- LESIONS
- BRAIN
- MODEL