Risk factors for squamous cell carcinoma of the oesophagus in women: a case-control study

Linda Sharp, C. E. Chilvers, P. A. McKinney, A. Ahmed, N. E. Day, K. K. Cheng, R. F. Logan, P. Cook-Mozaffari

    Research output: Contribution to journalArticle

    66 Citations (Scopus)

    Abstract

    Oesophageal cancer rates in women in the UK are more than 3 times higher than in most other European populations. A population-based matched case-control study of histologically confirmed squamous cell carcinoma of the oesophagus in women was carried out in 4 regions in England and Scotland. Interviews were carried out in hospital or at home and topics included: smoking; alcohol; tea and coffee consumption; medical and obstetric history; and diet. Response rates were 62% for cases and 65% for first-chosen controls. There were 159 case-control pairs. Significant results were found for: eating salads (odds ratio (OR) 0.42, 95% Cl 0.20-0.92 in the highest quartile of consumption) and a light (as distinct from no) breakfast (OR 0.18, 95% CI 0.07 - 0.48) were protective; quantity of tea was a risk factor and there was a significant positive trend with temperature at which hot drinks were consumed (P = 0.03). Alcohol consumption was unrelated to risk, but there was a significant trend with years of smoking (P = 0.015). A protective effect of aspirin consumption was confined to the English centres (OR 0.08, 95% CI 0.01-0.56). Comparison with a parallel study of adenocarcinoma indicated a common protective effect of a healthy diet but otherwise distinct risk factors. (C) 2001 Cancer Research Campaign.

    Original languageEnglish
    Pages (from-to)1667-1670
    Number of pages3
    JournalBritish Journal of Cancer
    Volume85
    Issue number11
    DOIs
    Publication statusPublished - 2001

    Keywords

    • oesophagus
    • cancer
    • case-control
    • aetiology
    • ESOPHAGEAL CANCER
    • ANTIINFLAMMATORY DRUGS

    Cite this

    Sharp, L., Chilvers, C. E., McKinney, P. A., Ahmed, A., Day, N. E., Cheng, K. K., ... Cook-Mozaffari, P. (2001). Risk factors for squamous cell carcinoma of the oesophagus in women: a case-control study. British Journal of Cancer, 85(11), 1667-1670. https://doi.org/10.1054/bjoc.2001.2147

    Risk factors for squamous cell carcinoma of the oesophagus in women: a case-control study. / Sharp, Linda; Chilvers, C. E.; McKinney, P. A.; Ahmed, A.; Day, N. E.; Cheng, K. K.; Logan, R. F.; Cook-Mozaffari, P.

    In: British Journal of Cancer, Vol. 85, No. 11, 2001, p. 1667-1670.

    Research output: Contribution to journalArticle

    Sharp, L, Chilvers, CE, McKinney, PA, Ahmed, A, Day, NE, Cheng, KK, Logan, RF & Cook-Mozaffari, P 2001, 'Risk factors for squamous cell carcinoma of the oesophagus in women: a case-control study', British Journal of Cancer, vol. 85, no. 11, pp. 1667-1670. https://doi.org/10.1054/bjoc.2001.2147
    Sharp, Linda ; Chilvers, C. E. ; McKinney, P. A. ; Ahmed, A. ; Day, N. E. ; Cheng, K. K. ; Logan, R. F. ; Cook-Mozaffari, P. / Risk factors for squamous cell carcinoma of the oesophagus in women: a case-control study. In: British Journal of Cancer. 2001 ; Vol. 85, No. 11. pp. 1667-1670.
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