Risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed

Helle Katrine Knutsen, Jan Alexander, Lars Barregård, Margherita Bignami, Beat Brüschweiler, Sandra Ceccatelli, Bruce Cottrill, Michael Dinovi, Lutz Edler, Bettina Grasl-Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Carlo Stefano Nebbia, Annette Petersen, Martin Rose, Alain-Claude Roudot, Tanja Schwerdtle, Christiane Vleminckx, Günter Vollmer, Heather Wallace & 7 others Chiara Dall'Asta, Gunnar Sundstøl Eriksen, Ionelia Taranu, Andrea Altieri, Ruth Roldán-Torres, Isabelle P. Oswald, EFSA Panel on Contaminants in the Food Chain (CONTAM)

Research output: Contribution to journalArticle

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Abstract

Fumonisins, mycotoxins primarily produced by Fusarium verticillioides and Fusarium proliferatum, occur predominantly in cereal grains, especially in maize. The European Commission asked EFSA for a scientific opinion on the risk to animal health related to fumonisins and their modified and hidden forms in feed. Fumonisin B1 (FB1), FB2 and FB3 are the most common forms of fumonisins in feedstuffs and thus were included in the assessment. FB1, FB2 and FB3 have the same mode of action and were considered as having similar toxicological profile and potencies. For fumonisins, the EFSA Panel on Contaminants in the Food Chain (CONTAM) identified no‐observed‐adverse‐effect levels (NOAELs) for cattle, pig, poultry (chicken, ducks and turkeys), horse, and lowest‐observed‐adverse‐effect levels (LOAELs) for fish (extrapolated from carp) and rabbits. No reference points could be identified for sheep, goats, dogs, cats and mink. The dietary exposure was estimated on 18,140 feed samples on FB1–3 representing most of the feed commodities with potential presence of fumonisins. Samples were collected between 2003 and 2016 from 19 different European countries, but most of them from four Member States. To take into account the possible occurrence of hidden forms, an additional factor of 1.6, derived from the literature, was applied to the occurrence data. Modified forms of fumonisins, for which no data were identified concerning both the occurrence and the toxicity, were not included in the assessment. Based on mean exposure estimates, the risk of adverse health effects of feeds containing FB1–3 was considered very low for ruminants, low for poultry, horse, rabbits, fish and of potential concern for pigs. The same conclusions apply to the sum of FB1–3 and their hidden forms, except for pigs for which the risk of adverse health effect was considered of concern.
Original languageEnglish
Article numbere05242
Number of pages144
JournalEFSA Journal
Volume16
Issue number5
Early online date25 May 2018
DOIs
Publication statusPublished - May 2018

Fingerprint

fumonisins
animal health
fumonisin B1
swine
poultry
adverse effects
Siganus
horses
Fusarium proliferatum
risk estimate
dietary exposure
mink
food contamination
food chain
products and commodities
carp
ducks
small cereal grains
ruminants
mechanism of action

Keywords

  • fumonisins
  • modified forms
  • hidden forms
  • feed
  • exposure
  • toxicity
  • animal health risk assessment

Cite this

Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B., Ceccatelli, S., ... EFSA Panel on Contaminants in the Food Chain (CONTAM) (2018). Risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed. EFSA Journal, 16(5), [e05242]. https://doi.org/10.2903/j.efsa.2018.5242

Risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed. / Knutsen, Helle Katrine ; Alexander, Jan; Barregård, Lars; Bignami, Margherita; Brüschweiler, Beat ; Ceccatelli, Sandra; Cottrill, Bruce; Dinovi, Michael; Edler, Lutz; Grasl-Kraupp, Bettina ; Hogstrand, Christer ; Hoogenboom, Laurentius (Ron) ; Nebbia, Carlo Stefano ; Petersen, Annette ; Rose, Martin ; Roudot, Alain-Claude ; Schwerdtle, Tanja ; Vleminckx, Christiane ; Vollmer, Günter ; Wallace, Heather; Dall'Asta, Chiara; Eriksen, Gunnar Sundstøl; Taranu, Ionelia; Altieri, Andrea; Roldán-Torres, Ruth; Oswald, Isabelle P.; EFSA Panel on Contaminants in the Food Chain (CONTAM).

In: EFSA Journal, Vol. 16, No. 5, e05242, 05.2018.

Research output: Contribution to journalArticle

Knutsen, HK, Alexander, J, Barregård, L, Bignami, M, Brüschweiler, B, Ceccatelli, S, Cottrill, B, Dinovi, M, Edler, L, Grasl-Kraupp, B, Hogstrand, C, Hoogenboom, LR, Nebbia, CS, Petersen, A, Rose, M, Roudot, A-C, Schwerdtle, T, Vleminckx, C, Vollmer, G, Wallace, H, Dall'Asta, C, Eriksen, GS, Taranu, I, Altieri, A, Roldán-Torres, R, Oswald, IP & EFSA Panel on Contaminants in the Food Chain (CONTAM) 2018, 'Risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed', EFSA Journal, vol. 16, no. 5, e05242. https://doi.org/10.2903/j.efsa.2018.5242
Knutsen HK, Alexander J, Barregård L, Bignami M, Brüschweiler B, Ceccatelli S et al. Risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed. EFSA Journal. 2018 May;16(5). e05242. https://doi.org/10.2903/j.efsa.2018.5242
Knutsen, Helle Katrine ; Alexander, Jan ; Barregård, Lars ; Bignami, Margherita ; Brüschweiler, Beat ; Ceccatelli, Sandra ; Cottrill, Bruce ; Dinovi, Michael ; Edler, Lutz ; Grasl-Kraupp, Bettina ; Hogstrand, Christer ; Hoogenboom, Laurentius (Ron) ; Nebbia, Carlo Stefano ; Petersen, Annette ; Rose, Martin ; Roudot, Alain-Claude ; Schwerdtle, Tanja ; Vleminckx, Christiane ; Vollmer, Günter ; Wallace, Heather ; Dall'Asta, Chiara ; Eriksen, Gunnar Sundstøl ; Taranu, Ionelia ; Altieri, Andrea ; Roldán-Torres, Ruth ; Oswald, Isabelle P. ; EFSA Panel on Contaminants in the Food Chain (CONTAM). / Risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed. In: EFSA Journal. 2018 ; Vol. 16, No. 5.
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AU - Knutsen, Helle Katrine

AU - Alexander, Jan

AU - Barregård, Lars

AU - Bignami, Margherita

AU - Brüschweiler, Beat

AU - Ceccatelli, Sandra

AU - Cottrill, Bruce

AU - Dinovi, Michael

AU - Edler, Lutz

AU - Grasl-Kraupp, Bettina

AU - Hogstrand, Christer

AU - Hoogenboom, Laurentius (Ron)

AU - Nebbia, Carlo Stefano

AU - Petersen, Annette

AU - Rose, Martin

AU - Roudot, Alain-Claude

AU - Schwerdtle, Tanja

AU - Vleminckx, Christiane

AU - Vollmer, Günter

AU - Wallace, Heather

AU - Dall'Asta, Chiara

AU - Eriksen, Gunnar Sundstøl

AU - Taranu, Ionelia

AU - Altieri, Andrea

AU - Roldán-Torres, Ruth

AU - Oswald, Isabelle P.

AU - EFSA Panel on Contaminants in the Food Chain (CONTAM)

N1 - The CONTAM Panel wishes to acknowledge all European countries and other stakeholder organisations that provided feed consumption data and chemical occurrence data on fumonisins, modified forms and hidden forms in feed. Adopted: 22 March 2018

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N2 - Fumonisins, mycotoxins primarily produced by Fusarium verticillioides and Fusarium proliferatum, occur predominantly in cereal grains, especially in maize. The European Commission asked EFSA for a scientific opinion on the risk to animal health related to fumonisins and their modified and hidden forms in feed. Fumonisin B1 (FB1), FB2 and FB3 are the most common forms of fumonisins in feedstuffs and thus were included in the assessment. FB1, FB2 and FB3 have the same mode of action and were considered as having similar toxicological profile and potencies. For fumonisins, the EFSA Panel on Contaminants in the Food Chain (CONTAM) identified no‐observed‐adverse‐effect levels (NOAELs) for cattle, pig, poultry (chicken, ducks and turkeys), horse, and lowest‐observed‐adverse‐effect levels (LOAELs) for fish (extrapolated from carp) and rabbits. No reference points could be identified for sheep, goats, dogs, cats and mink. The dietary exposure was estimated on 18,140 feed samples on FB1–3 representing most of the feed commodities with potential presence of fumonisins. Samples were collected between 2003 and 2016 from 19 different European countries, but most of them from four Member States. To take into account the possible occurrence of hidden forms, an additional factor of 1.6, derived from the literature, was applied to the occurrence data. Modified forms of fumonisins, for which no data were identified concerning both the occurrence and the toxicity, were not included in the assessment. Based on mean exposure estimates, the risk of adverse health effects of feeds containing FB1–3 was considered very low for ruminants, low for poultry, horse, rabbits, fish and of potential concern for pigs. The same conclusions apply to the sum of FB1–3 and their hidden forms, except for pigs for which the risk of adverse health effect was considered of concern.

AB - Fumonisins, mycotoxins primarily produced by Fusarium verticillioides and Fusarium proliferatum, occur predominantly in cereal grains, especially in maize. The European Commission asked EFSA for a scientific opinion on the risk to animal health related to fumonisins and their modified and hidden forms in feed. Fumonisin B1 (FB1), FB2 and FB3 are the most common forms of fumonisins in feedstuffs and thus were included in the assessment. FB1, FB2 and FB3 have the same mode of action and were considered as having similar toxicological profile and potencies. For fumonisins, the EFSA Panel on Contaminants in the Food Chain (CONTAM) identified no‐observed‐adverse‐effect levels (NOAELs) for cattle, pig, poultry (chicken, ducks and turkeys), horse, and lowest‐observed‐adverse‐effect levels (LOAELs) for fish (extrapolated from carp) and rabbits. No reference points could be identified for sheep, goats, dogs, cats and mink. The dietary exposure was estimated on 18,140 feed samples on FB1–3 representing most of the feed commodities with potential presence of fumonisins. Samples were collected between 2003 and 2016 from 19 different European countries, but most of them from four Member States. To take into account the possible occurrence of hidden forms, an additional factor of 1.6, derived from the literature, was applied to the occurrence data. Modified forms of fumonisins, for which no data were identified concerning both the occurrence and the toxicity, were not included in the assessment. Based on mean exposure estimates, the risk of adverse health effects of feeds containing FB1–3 was considered very low for ruminants, low for poultry, horse, rabbits, fish and of potential concern for pigs. The same conclusions apply to the sum of FB1–3 and their hidden forms, except for pigs for which the risk of adverse health effect was considered of concern.

KW - fumonisins

KW - modified forms

KW - hidden forms

KW - feed

KW - exposure

KW - toxicity

KW - animal health risk assessment

U2 - 10.2903/j.efsa.2018.5242

DO - 10.2903/j.efsa.2018.5242

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VL - 16

JO - EFSA Journal

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SN - 1831-4732

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