Role of Mitochondria and Oxidative stress in Parkinson's disease

Renato Xavier Coelho Dos Santos; Sónia C Correia; Susana Cardoso; Cristina Carvalho; Emanuel  Candeias; Ana I Plácido; Ana I Duarte; Maria Sancha Santos; Paula Isabel da Silva Moreira

Role of Mitochondria and Oxidative stress in Parkinson's disease

Renato Xavier Coelho Dos Santos, Sónia C Correia, Susana Cardoso, Cristina Carvalho, Emanuel Candeias, Ana I Plácido, Ana I Duarte , Maria Sancha Santos, Paula Isabel da Silva Moreira

University of Coimbra

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract

Parkinson’s disease (PD) is a movement disorder mainly characterized by rigidity, bradykinesia/akinesia, postural instability and resting tremor (Gelb et al. 1999, Jankovic 2008). PD results from the degenerative loss of dopaminergic neurons projecting from the substantia nigra pars compacta (SNpc) into the striatum. Another hallmark of this neurodegenerative disorder is the cytosolic accumulation of aberrant protein aggregates named Lewy bodies (LB), mostly composed of proteins that include α-synuclein, parkin, ubiquitin, synphilin and neurofi laments (Lee and Liu 2008, Arduíno et al. 2011).

Original language	English
Title of host publication	Role of Oxidative Stress in Chronic Diseases
Editors	Isaias Dichi, José Wander Breganó, Andréa Name Colado Simão, Rubens Cecchini
Publisher	CRC Press
Chapter	5
Pages	521-548
Number of pages	28
ISBN (Electronic)	9780429075957
ISBN (Print)	9781482216813
Publication status	Published - 14 Mar 2014
Externally published	Yes

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https://www.taylorfrancis.com/books/e/9780429075957/chapters/10.1201/b16653-28Licence: Unspecified

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Coelho Dos Santos, R. X., Correia, S. C., Cardoso, S., Carvalho, C., Candeias, E., Plácido, A. I., Duarte , A. I., Santos, M. S., & da Silva Moreira, P. I. (2014). Role of Mitochondria and Oxidative stress in Parkinson's disease. In I. Dichi, J. W. Breganó, A. N. Colado Simão, & R. Cecchini (Eds.), Role of Oxidative Stress in Chronic Diseases (pp. 521-548). Article 3 CRC Press. https://www.taylorfrancis.com/books/e/9780429075957/chapters/10.1201/b16653-28

Role of Mitochondria and Oxidative stress in Parkinson's disease. / Coelho Dos Santos, Renato Xavier; Correia, Sónia C; Cardoso, Susana et al.
Role of Oxidative Stress in Chronic Diseases. ed. / Isaias Dichi; José Wander Breganó; Andréa Name Colado Simão; Rubens Cecchini. CRC Press, 2014. p. 521-548 3.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Coelho Dos Santos, RX, Correia, SC, Cardoso, S, Carvalho, C, Candeias, E, Plácido, AI, Duarte , AI, Santos, MS & da Silva Moreira, PI 2014, Role of Mitochondria and Oxidative stress in Parkinson's disease. in I Dichi, JW Breganó, AN Colado Simão & R Cecchini (eds), Role of Oxidative Stress in Chronic Diseases., 3, CRC Press, pp. 521-548. <https://www.taylorfrancis.com/books/e/9780429075957/chapters/10.1201/b16653-28>

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abstract = "Parkinson{\textquoteright}s disease (PD) is a movement disorder mainly characterized by rigidity, bradykinesia/akinesia, postural instability and resting tremor (Gelb et al. 1999, Jankovic 2008). PD results from the degenerative loss of dopaminergic neurons projecting from the substantia nigra pars compacta (SNpc) into the striatum. Another hallmark of this neurodegenerative disorder is the cytosolic accumulation of aberrant protein aggregates named Lewy bodies (LB), mostly composed of proteins that include α-synuclein, parkin, ubiquitin, synphilin and neurofi laments (Lee and Liu 2008, Ardu{\'i}no et al. 2011).",

author = "{Coelho Dos Santos}, {Renato Xavier} and Correia, {S{\'o}nia C} and Susana Cardoso and Cristina Carvalho and Emanuel Candeias and Pl{\'a}cido, {Ana I} and Duarte, {Ana I} and Santos, {Maria Sancha} and {da Silva Moreira}, {Paula Isabel}",

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T1 - Role of Mitochondria and Oxidative stress in Parkinson's disease

AU - Coelho Dos Santos, Renato Xavier

AU - Correia, Sónia C

AU - Cardoso, Susana

AU - Carvalho, Cristina

AU - Candeias, Emanuel

AU - Plácido, Ana I

AU - Duarte , Ana I

AU - Santos, Maria Sancha

AU - da Silva Moreira, Paula Isabel

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N2 - Parkinson’s disease (PD) is a movement disorder mainly characterized by rigidity, bradykinesia/akinesia, postural instability and resting tremor (Gelb et al. 1999, Jankovic 2008). PD results from the degenerative loss of dopaminergic neurons projecting from the substantia nigra pars compacta (SNpc) into the striatum. Another hallmark of this neurodegenerative disorder is the cytosolic accumulation of aberrant protein aggregates named Lewy bodies (LB), mostly composed of proteins that include α-synuclein, parkin, ubiquitin, synphilin and neurofi laments (Lee and Liu 2008, Arduíno et al. 2011).

AB - Parkinson’s disease (PD) is a movement disorder mainly characterized by rigidity, bradykinesia/akinesia, postural instability and resting tremor (Gelb et al. 1999, Jankovic 2008). PD results from the degenerative loss of dopaminergic neurons projecting from the substantia nigra pars compacta (SNpc) into the striatum. Another hallmark of this neurodegenerative disorder is the cytosolic accumulation of aberrant protein aggregates named Lewy bodies (LB), mostly composed of proteins that include α-synuclein, parkin, ubiquitin, synphilin and neurofi laments (Lee and Liu 2008, Arduíno et al. 2011).

M3 - Chapter (peer-reviewed)

SN - 9781482216813

SP - 521

EP - 548

BT - Role of Oxidative Stress in Chronic Diseases

A2 - Dichi, Isaias

A2 - Breganó, José Wander

A2 - Colado Simão, Andréa Name

A2 - Cecchini, Rubens

PB - CRC Press

ER -

Role of Mitochondria and Oxidative stress in Parkinson's disease

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