Role of Mitochondria and Oxidative stress in Parkinson's disease

Renato Xavier Coelho Dos Santos, Sónia C Correia, Susana Cardoso, Cristina Carvalho, Emanuel Candeias, Ana I Plácido, Ana I Duarte , Maria Sancha Santos, Paula Isabel da Silva Moreira

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

Parkinson’s disease (PD) is a movement disorder mainly characterized by rigidity, bradykinesia/akinesia, postural instability and resting tremor (Gelb et al. 1999, Jankovic 2008). PD results from the degenerative loss of dopaminergic neurons projecting from the substantia nigra pars compacta (SNpc) into the striatum. Another hallmark of this neurodegenerative disorder is the cytosolic accumulation of aberrant protein aggregates named Lewy bodies (LB), mostly composed of proteins that include α-synuclein, parkin, ubiquitin, synphilin and neurofi laments (Lee and Liu 2008, Arduíno et al. 2011).
Original languageEnglish
Title of host publicationRole of Oxidative Stress in Chronic Diseases
EditorsIsaias Dichi, José Wander Breganó, Andréa Name Colado Simão, Rubens Cecchini
PublisherCRC Press
Chapter5
Pages521-548
Number of pages28
ISBN (Electronic)9780429075957
ISBN (Print)9781482216813
Publication statusPublished - 14 Mar 2014

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