Role of Pullulan in preparation of ceria nanoparticles and investigation of their biological activities

Mohammad Bagher Khorrami; Hamid Reza Sadeghnia; Alireza Pasdar; Majid Ghayour-Mobarhan; Bamdad Riahi-Zanjani; Majid Darroudi

doi:10.1016/j.molstruc.2017.12.053

Role of Pullulan in preparation of ceria nanoparticles and investigation of their biological activities

Mohammad Bagher Khorrami, Hamid Reza Sadeghnia, Alireza Pasdar, Majid Ghayour-Mobarhan, Bamdad Riahi-Zanjani, Majid Darroudi^*

^*Corresponding author for this work

Applied Medicine

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Throughout this work, a facile, environmental–friendly, and “green” method is delineated for preparing ceria nanoparticles (CNPs), which utilizes nontoxic and renewable degraded polysaccharide polymer including pullulan as a natural matrix. Pullulan behaves as a suitable stabilizing (capping) agent for CNPs that are effectively formed at various high temperatures, while they are structurally analyzed through different techniques such as TGA/DTG, XRD, FESEM, and FTIR instruments. This procedure was found to be comparable to the ones that were acquired from conventional preparation methods that employ hazardous materials, which confirms this approach to be an exquisite alternative in preparing CNPs through the benefit of bioorganic materials. The in vitro cytotoxicity studies on Neuro2A cells have mentioned nontoxic particles in a range of concentrations (0.97–125 μg/ml) and thus, we reckon that the prepared particular CNPs will have persistent utilization in various fields of biology and medicine.

Original language	English
Pages (from-to)	127-131
Number of pages	5
Journal	Journal of Molecular Structure
Volume	1157
Early online date	20 Dec 2017
DOIs	https://doi.org/10.1016/j.molstruc.2017.12.053
Publication status	Published - 5 Apr 2018

Bibliographical note

M. Darroudi thankfully acknowledge for technical and ﬁnancial support for this project provided by Mashhad University of Medical Sciences (Grant # 930954) based on the PhD thesis of Mr. M.B. Khorrami.

Keywords

Ceria (CeO)
Cytotoxicity
Electron microscopy
Nanoparticles
Pullulan

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Throughout this work, a facile, environmental–friendly, and “green” method is delineated for preparing ceria nanoparticles (CNPs), which utilizes nontoxic and renewable degraded polysaccharide polymer including pullulan as a natural matrix. Pullulan behaves as a suitable stabilizing (capping) agent for CNPs that are effectively formed at various high temperatures, while they are structurally analyzed through different techniques such as TGA/DTG, XRD, FESEM, and FTIR instruments. This procedure was found to be comparable to the ones that were acquired from conventional preparation methods that employ hazardous materials, which confirms this approach to be an exquisite alternative in preparing CNPs through the benefit of bioorganic materials. The in vitro cytotoxicity studies on Neuro2A cells have mentioned nontoxic particles in a range of concentrations (0.97–125 μg/ml) and thus, we reckon that the prepared particular CNPs will have persistent utilization in various fields of biology and medicine.",

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note = "M. Darroudi thankfully acknowledge for technical and ﬁnancial support for this project provided by Mashhad University of Medical Sciences (Grant # 930954) based on the PhD thesis of Mr. M.B. Khorrami. ",

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AU - Khorrami, Mohammad Bagher

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AU - Pasdar, Alireza

AU - Ghayour-Mobarhan, Majid

AU - Riahi-Zanjani, Bamdad

AU - Darroudi, Majid

N1 - M. Darroudi thankfully acknowledge for technical and ﬁnancial support for this project provided by Mashhad University of Medical Sciences (Grant # 930954) based on the PhD thesis of Mr. M.B. Khorrami.

PY - 2018/4/5

Y1 - 2018/4/5

N2 - Throughout this work, a facile, environmental–friendly, and “green” method is delineated for preparing ceria nanoparticles (CNPs), which utilizes nontoxic and renewable degraded polysaccharide polymer including pullulan as a natural matrix. Pullulan behaves as a suitable stabilizing (capping) agent for CNPs that are effectively formed at various high temperatures, while they are structurally analyzed through different techniques such as TGA/DTG, XRD, FESEM, and FTIR instruments. This procedure was found to be comparable to the ones that were acquired from conventional preparation methods that employ hazardous materials, which confirms this approach to be an exquisite alternative in preparing CNPs through the benefit of bioorganic materials. The in vitro cytotoxicity studies on Neuro2A cells have mentioned nontoxic particles in a range of concentrations (0.97–125 μg/ml) and thus, we reckon that the prepared particular CNPs will have persistent utilization in various fields of biology and medicine.

AB - Throughout this work, a facile, environmental–friendly, and “green” method is delineated for preparing ceria nanoparticles (CNPs), which utilizes nontoxic and renewable degraded polysaccharide polymer including pullulan as a natural matrix. Pullulan behaves as a suitable stabilizing (capping) agent for CNPs that are effectively formed at various high temperatures, while they are structurally analyzed through different techniques such as TGA/DTG, XRD, FESEM, and FTIR instruments. This procedure was found to be comparable to the ones that were acquired from conventional preparation methods that employ hazardous materials, which confirms this approach to be an exquisite alternative in preparing CNPs through the benefit of bioorganic materials. The in vitro cytotoxicity studies on Neuro2A cells have mentioned nontoxic particles in a range of concentrations (0.97–125 μg/ml) and thus, we reckon that the prepared particular CNPs will have persistent utilization in various fields of biology and medicine.

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Role of Pullulan in preparation of ceria nanoparticles and investigation of their biological activities

Abstract

Bibliographical note

Keywords

UN SDGs

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