Role of structural inhomogeneities in resting-state brain dynamics

Vesna Vuksanovic, Philipp Hövel

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Brain imaging methods allow a non-invasive assessment of both structural and functional connectivity. However, the mechanism of how functional connectivity arises in a structured network of interacting neural populations is as yet poorly understood. Here we use a modeling approach to explore the way in which functional correlations arise from underlying structural connections taking into account inhomogeneities in the interactions between the brain regions of interest. The local dynamics of a neural population is assumed to be of phase-oscillator type. The considered structural connectivity patterns describe long-range anatomical connections between interacting neural elements. We find a dependence of the simulated functional connectivity patterns on the parameters governing the dynamics. We calculate graph-theoretic measures of the functional network topology obtained from numerical simulations. The effect of structural inhomogeneities in the coupling term on the observed network state is quantified by examining the relation between simulated and empirical functional connectivity. Importantly, we show that simulated and empirical functional connectivity agree for a narrow range of coupling strengths. We conclude that identification of functional connectivity during rest requires an analysis of the network dynamics.
Original languageEnglish
Pages (from-to)361-365
Number of pages5
JournalCognitive Neurodynamics
Volume10
Issue number4
Early online date24 Feb 2016
DOIs
Publication statusPublished - Aug 2016

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Keywords

  • functional connectivity
  • brain dynamics model
  • graph theory
  • structural connectivity

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