Searching for genetic influences on normal cognitive ageing

I. J. Deary, A. F. Wright, S. E. Harris, Lawrence Jeffrey Whalley, J. M. Starr

    Research output: Contribution to journalArticle

    55 Citations (Scopus)

    Abstract

    Differences in non-pathological cognitive ageing provide a useful case study for the opportunities and challenges facing cognitive science as it embraces advances in genetics. One replicated contributor to these differences is variability in the gene for apolipoprotein E. Genetic variations that influence neurodegenerative diseases, learning and memory, cardiovascular disease, and oxidative stress are among the candidates for influence on cognitive ageing differences. The area suffers the same problems as other domains in which quantitative trait loci are sought: uncertainty regarding the genetic architecture, unreliable strategies for candidate gene selection, lack of power leading to unreplicated findings, and poor characterisation of the phenotype. However, current progress in genetic knowledge, technology and informatics will contribute to progress in this important area.

    Original languageEnglish
    Pages (from-to)178-184
    Number of pages6
    JournalTrends in Cognitive Sciences
    Volume8
    DOIs
    Publication statusPublished - 2004

    Keywords

    • QUANTITATIVE-TRAIT LOCI
    • APOLIPOPROTEIN-E GENOTYPE
    • HUMAN GENOME
    • LINKAGE DISEQUILIBRIUM
    • HAPLOTYPE BLOCKS
    • COMPLEX TRAITS
    • OLDER ADULTS
    • HUMAN-MEMORY
    • POLYMORPHISM
    • DISEASE

    Cite this

    Deary, I. J., Wright, A. F., Harris, S. E., Whalley, L. J., & Starr, J. M. (2004). Searching for genetic influences on normal cognitive ageing. Trends in Cognitive Sciences, 8, 178-184. https://doi.org/10.1016/j.tics.2004.02.008