Searching for genetic influences on normal cognitive ageing

I. J. Deary; A. F. Wright; S. E. Harris; Lawrence Jeffrey Whalley; J. M. Starr

doi:10.1016/j.tics.2004.02.008

Searching for genetic influences on normal cognitive ageing

I. J. Deary, A. F. Wright, S. E. Harris, Lawrence Jeffrey Whalley, J. M. Starr

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Differences in non-pathological cognitive ageing provide a useful case study for the opportunities and challenges facing cognitive science as it embraces advances in genetics. One replicated contributor to these differences is variability in the gene for apolipoprotein E. Genetic variations that influence neurodegenerative diseases, learning and memory, cardiovascular disease, and oxidative stress are among the candidates for influence on cognitive ageing differences. The area suffers the same problems as other domains in which quantitative trait loci are sought: uncertainty regarding the genetic architecture, unreliable strategies for candidate gene selection, lack of power leading to unreplicated findings, and poor characterisation of the phenotype. However, current progress in genetic knowledge, technology and informatics will contribute to progress in this important area.

Original language	English
Pages (from-to)	178-184
Number of pages	6
Journal	Trends in Cognitive Sciences
Volume	8
DOIs	https://doi.org/10.1016/j.tics.2004.02.008
Publication status	Published - 2004

Keywords

QUANTITATIVE-TRAIT LOCI
APOLIPOPROTEIN-E GENOTYPE
HUMAN GENOME
LINKAGE DISEQUILIBRIUM
HAPLOTYPE BLOCKS
COMPLEX TRAITS
OLDER ADULTS
HUMAN-MEMORY
POLYMORPHISM
DISEASE

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tics.2004.02.008

Cite this

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title = "Searching for genetic influences on normal cognitive ageing",

abstract = "Differences in non-pathological cognitive ageing provide a useful case study for the opportunities and challenges facing cognitive science as it embraces advances in genetics. One replicated contributor to these differences is variability in the gene for apolipoprotein E. Genetic variations that influence neurodegenerative diseases, learning and memory, cardiovascular disease, and oxidative stress are among the candidates for influence on cognitive ageing differences. The area suffers the same problems as other domains in which quantitative trait loci are sought: uncertainty regarding the genetic architecture, unreliable strategies for candidate gene selection, lack of power leading to unreplicated findings, and poor characterisation of the phenotype. However, current progress in genetic knowledge, technology and informatics will contribute to progress in this important area.",

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author = "Deary, {I. J.} and Wright, {A. F.} and Harris, {S. E.} and Whalley, {Lawrence Jeffrey} and Starr, {J. M.}",

year = "2004",

doi = "10.1016/j.tics.2004.02.008",

language = "English",

volume = "8",

pages = "178--184",

journal = "Trends in Cognitive Sciences",

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T1 - Searching for genetic influences on normal cognitive ageing

AU - Deary, I. J.

AU - Wright, A. F.

AU - Harris, S. E.

AU - Whalley, Lawrence Jeffrey

AU - Starr, J. M.

PY - 2004

Y1 - 2004

N2 - Differences in non-pathological cognitive ageing provide a useful case study for the opportunities and challenges facing cognitive science as it embraces advances in genetics. One replicated contributor to these differences is variability in the gene for apolipoprotein E. Genetic variations that influence neurodegenerative diseases, learning and memory, cardiovascular disease, and oxidative stress are among the candidates for influence on cognitive ageing differences. The area suffers the same problems as other domains in which quantitative trait loci are sought: uncertainty regarding the genetic architecture, unreliable strategies for candidate gene selection, lack of power leading to unreplicated findings, and poor characterisation of the phenotype. However, current progress in genetic knowledge, technology and informatics will contribute to progress in this important area.

AB - Differences in non-pathological cognitive ageing provide a useful case study for the opportunities and challenges facing cognitive science as it embraces advances in genetics. One replicated contributor to these differences is variability in the gene for apolipoprotein E. Genetic variations that influence neurodegenerative diseases, learning and memory, cardiovascular disease, and oxidative stress are among the candidates for influence on cognitive ageing differences. The area suffers the same problems as other domains in which quantitative trait loci are sought: uncertainty regarding the genetic architecture, unreliable strategies for candidate gene selection, lack of power leading to unreplicated findings, and poor characterisation of the phenotype. However, current progress in genetic knowledge, technology and informatics will contribute to progress in this important area.

KW - QUANTITATIVE-TRAIT LOCI

KW - APOLIPOPROTEIN-E GENOTYPE

KW - HUMAN GENOME

KW - LINKAGE DISEQUILIBRIUM

KW - HAPLOTYPE BLOCKS

KW - COMPLEX TRAITS

KW - OLDER ADULTS

KW - HUMAN-MEMORY

KW - POLYMORPHISM

KW - DISEASE

U2 - 10.1016/j.tics.2004.02.008

DO - 10.1016/j.tics.2004.02.008

M3 - Article

SN - 1364-6613

VL - 8

SP - 178

EP - 184

JO - Trends in Cognitive Sciences

JF - Trends in Cognitive Sciences

ER -

Searching for genetic influences on normal cognitive ageing

Abstract

Keywords

UN SDGs

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