Abstract
Much research into the functions of selenium in the cell has concentrated on its role in selenium-containing glutathione peroxidases. However, selenium was recently shown to be an essential component of type I iodothyronine 5'-deiodinase in rats, which converts thyroxin to the more biologically active hormone 3,5,3-triiodothyronine. Thus, selenium-deficient rats have low tissue deiodinase activities and abnormal thyroid hormone metabolism. The discovery of this function for selenium in thyroid hormone metabolism has important implications for the interpretation of the effects of selenium deficiency, especially in individuals with an adequate vitamin E status.
Original language | English |
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Pages (from-to) | 236S-239S |
Number of pages | 4 |
Journal | The American Journal of Clinical Nutrition |
Volume | 57 |
Issue number | 2 |
Publication status | Published - Feb 1993 |
Keywords
- selenium deficiency
- iodothyronine deiodinases
- glutathione peroxidase
- thyroid
- thyroid hormones
- iodine
- liver iodothyronine deiodinase
- hepatic enzyme modulations
- brown adipose-tissue
- rat-liver
- glutathione-peroxidase
- 5'-deiodinase activity
- partial-purification
- drug-metabolism
- I 5'-deiodinase
- kidney