Selenium status parameters in patients with polycystic ovary syndrome

P. Zagrodzki*, M. Krzyczkowska-Sendrakowska, F. Nicol, R. Wietecha-Posłuszny, T. Milewicz, J. Kryczyk-Kozioł, Z. Chaykivska, R. Jach

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. To date, no systematic study of interactions between selenium status parameters (SSPs: serum selenium concentration, plasma glutathione peroxidase, GPX3, plasma selenoprotein P, SELENOP), sex hormones, thyroid function parameters, and other laboratory parameters in patients with PCOS has been undertaken. Therefore we aimed to compare such parameters in women with PCOS and in the control groups, and to investigate the multidimensional interactions between various parameters in PCOS patients and in controls. The subjects were diagnosed either with PCOS (n = 28, 25.4 ± 5.2 y) or with PCOS + Hashimoto disease (n = 13, 27.3 ± 5.6 y). Female patients having normal menses were recruited into the first control group (n = 70, 26.8 ± 7.3 y) or to the second control group comprising women only with Hashimoto disease (n = 10, 26.2 ± 6.9 y). No apparent differences in SSPs between control subjects and patients with PCOS, also complicated with Hashimoto disease, were identified, though such differences were noticeable for total testosterone (tT), sex hormone binding globulin, free androgen index, dehydroepiandrosterone sulfate (DHEAS), and insulin profile. The correlation between tT and DHEAS was found the strongest. The other group of mutually highly and positively correlated parameters consisted of GPX3, follicle stimulating hormone, free triiodothyronine and free thyroxine. All the latter parameters correlated negatively with vitamin D3. SSPs took part in interactions with thyroid hormones, sex hormones and some other parameters, but only for GPX3 such interactions were statistically significant. The significance of these findings remains open for further investigation, particularly in patients with PCOS and/or Hashimoto disease.

Original languageEnglish
Pages (from-to)241-246
Number of pages6
JournalJournal of Trace Elements in Medicine and Biology
Volume44
Early online date24 Aug 2017
DOIs
Publication statusPublished - 1 Dec 2017

Fingerprint

Polycystic Ovary Syndrome
Selenium
Hashimoto Disease
Dehydroepiandrosterone Sulfate
Gonadal Steroid Hormones
Testosterone
Selenoprotein P
Plasmas
Sex Hormone-Binding Globulin
Control Groups
Cholecalciferol
Follicle Stimulating Hormone
Triiodothyronine
Glutathione Peroxidase
Thyroxine
Thyroid Hormones
Androgens
Menstruation
Insulin
Thyroid Gland

Keywords

  • Hashimoto disease
  • Partial Least Squares model
  • Polycystic ovary syndrome
  • Selenium

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Inorganic Chemistry

Cite this

Zagrodzki, P., Krzyczkowska-Sendrakowska, M., Nicol, F., Wietecha-Posłuszny, R., Milewicz, T., Kryczyk-Kozioł, J., ... Jach, R. (2017). Selenium status parameters in patients with polycystic ovary syndrome. Journal of Trace Elements in Medicine and Biology, 44, 241-246. https://doi.org/10.1016/j.jtemb.2017.08.012

Selenium status parameters in patients with polycystic ovary syndrome. / Zagrodzki, P.; Krzyczkowska-Sendrakowska, M.; Nicol, F.; Wietecha-Posłuszny, R.; Milewicz, T.; Kryczyk-Kozioł, J.; Chaykivska, Z.; Jach, R.

In: Journal of Trace Elements in Medicine and Biology, Vol. 44, 01.12.2017, p. 241-246.

Research output: Contribution to journalArticle

Zagrodzki, P, Krzyczkowska-Sendrakowska, M, Nicol, F, Wietecha-Posłuszny, R, Milewicz, T, Kryczyk-Kozioł, J, Chaykivska, Z & Jach, R 2017, 'Selenium status parameters in patients with polycystic ovary syndrome', Journal of Trace Elements in Medicine and Biology, vol. 44, pp. 241-246. https://doi.org/10.1016/j.jtemb.2017.08.012
Zagrodzki P, Krzyczkowska-Sendrakowska M, Nicol F, Wietecha-Posłuszny R, Milewicz T, Kryczyk-Kozioł J et al. Selenium status parameters in patients with polycystic ovary syndrome. Journal of Trace Elements in Medicine and Biology. 2017 Dec 1;44:241-246. https://doi.org/10.1016/j.jtemb.2017.08.012
Zagrodzki, P. ; Krzyczkowska-Sendrakowska, M. ; Nicol, F. ; Wietecha-Posłuszny, R. ; Milewicz, T. ; Kryczyk-Kozioł, J. ; Chaykivska, Z. ; Jach, R. / Selenium status parameters in patients with polycystic ovary syndrome. In: Journal of Trace Elements in Medicine and Biology. 2017 ; Vol. 44. pp. 241-246.
@article{5b92d416dcc64a10a7b45f4f652e89ca,
title = "Selenium status parameters in patients with polycystic ovary syndrome",
abstract = "Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. To date, no systematic study of interactions between selenium status parameters (SSPs: serum selenium concentration, plasma glutathione peroxidase, GPX3, plasma selenoprotein P, SELENOP), sex hormones, thyroid function parameters, and other laboratory parameters in patients with PCOS has been undertaken. Therefore we aimed to compare such parameters in women with PCOS and in the control groups, and to investigate the multidimensional interactions between various parameters in PCOS patients and in controls. The subjects were diagnosed either with PCOS (n = 28, 25.4 ± 5.2 y) or with PCOS + Hashimoto disease (n = 13, 27.3 ± 5.6 y). Female patients having normal menses were recruited into the first control group (n = 70, 26.8 ± 7.3 y) or to the second control group comprising women only with Hashimoto disease (n = 10, 26.2 ± 6.9 y). No apparent differences in SSPs between control subjects and patients with PCOS, also complicated with Hashimoto disease, were identified, though such differences were noticeable for total testosterone (tT), sex hormone binding globulin, free androgen index, dehydroepiandrosterone sulfate (DHEAS), and insulin profile. The correlation between tT and DHEAS was found the strongest. The other group of mutually highly and positively correlated parameters consisted of GPX3, follicle stimulating hormone, free triiodothyronine and free thyroxine. All the latter parameters correlated negatively with vitamin D3. SSPs took part in interactions with thyroid hormones, sex hormones and some other parameters, but only for GPX3 such interactions were statistically significant. The significance of these findings remains open for further investigation, particularly in patients with PCOS and/or Hashimoto disease.",
keywords = "Hashimoto disease, Partial Least Squares model, Polycystic ovary syndrome, Selenium",
author = "P. Zagrodzki and M. Krzyczkowska-Sendrakowska and F. Nicol and R. Wietecha-Posłuszny and T. Milewicz and J. Kryczyk-Kozioł and Z. Chaykivska and R. Jach",
year = "2017",
month = "12",
day = "1",
doi = "10.1016/j.jtemb.2017.08.012",
language = "English",
volume = "44",
pages = "241--246",
journal = "Journal of Trace Elements in Medicine and Biology",
issn = "0946-672X",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",

}

TY - JOUR

T1 - Selenium status parameters in patients with polycystic ovary syndrome

AU - Zagrodzki, P.

AU - Krzyczkowska-Sendrakowska, M.

AU - Nicol, F.

AU - Wietecha-Posłuszny, R.

AU - Milewicz, T.

AU - Kryczyk-Kozioł, J.

AU - Chaykivska, Z.

AU - Jach, R.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. To date, no systematic study of interactions between selenium status parameters (SSPs: serum selenium concentration, plasma glutathione peroxidase, GPX3, plasma selenoprotein P, SELENOP), sex hormones, thyroid function parameters, and other laboratory parameters in patients with PCOS has been undertaken. Therefore we aimed to compare such parameters in women with PCOS and in the control groups, and to investigate the multidimensional interactions between various parameters in PCOS patients and in controls. The subjects were diagnosed either with PCOS (n = 28, 25.4 ± 5.2 y) or with PCOS + Hashimoto disease (n = 13, 27.3 ± 5.6 y). Female patients having normal menses were recruited into the first control group (n = 70, 26.8 ± 7.3 y) or to the second control group comprising women only with Hashimoto disease (n = 10, 26.2 ± 6.9 y). No apparent differences in SSPs between control subjects and patients with PCOS, also complicated with Hashimoto disease, were identified, though such differences were noticeable for total testosterone (tT), sex hormone binding globulin, free androgen index, dehydroepiandrosterone sulfate (DHEAS), and insulin profile. The correlation between tT and DHEAS was found the strongest. The other group of mutually highly and positively correlated parameters consisted of GPX3, follicle stimulating hormone, free triiodothyronine and free thyroxine. All the latter parameters correlated negatively with vitamin D3. SSPs took part in interactions with thyroid hormones, sex hormones and some other parameters, but only for GPX3 such interactions were statistically significant. The significance of these findings remains open for further investigation, particularly in patients with PCOS and/or Hashimoto disease.

AB - Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. To date, no systematic study of interactions between selenium status parameters (SSPs: serum selenium concentration, plasma glutathione peroxidase, GPX3, plasma selenoprotein P, SELENOP), sex hormones, thyroid function parameters, and other laboratory parameters in patients with PCOS has been undertaken. Therefore we aimed to compare such parameters in women with PCOS and in the control groups, and to investigate the multidimensional interactions between various parameters in PCOS patients and in controls. The subjects were diagnosed either with PCOS (n = 28, 25.4 ± 5.2 y) or with PCOS + Hashimoto disease (n = 13, 27.3 ± 5.6 y). Female patients having normal menses were recruited into the first control group (n = 70, 26.8 ± 7.3 y) or to the second control group comprising women only with Hashimoto disease (n = 10, 26.2 ± 6.9 y). No apparent differences in SSPs between control subjects and patients with PCOS, also complicated with Hashimoto disease, were identified, though such differences were noticeable for total testosterone (tT), sex hormone binding globulin, free androgen index, dehydroepiandrosterone sulfate (DHEAS), and insulin profile. The correlation between tT and DHEAS was found the strongest. The other group of mutually highly and positively correlated parameters consisted of GPX3, follicle stimulating hormone, free triiodothyronine and free thyroxine. All the latter parameters correlated negatively with vitamin D3. SSPs took part in interactions with thyroid hormones, sex hormones and some other parameters, but only for GPX3 such interactions were statistically significant. The significance of these findings remains open for further investigation, particularly in patients with PCOS and/or Hashimoto disease.

KW - Hashimoto disease

KW - Partial Least Squares model

KW - Polycystic ovary syndrome

KW - Selenium

UR - http://www.scopus.com/inward/record.url?scp=85028507039&partnerID=8YFLogxK

U2 - 10.1016/j.jtemb.2017.08.012

DO - 10.1016/j.jtemb.2017.08.012

M3 - Article

AN - SCOPUS:85028507039

VL - 44

SP - 241

EP - 246

JO - Journal of Trace Elements in Medicine and Biology

JF - Journal of Trace Elements in Medicine and Biology

SN - 0946-672X

ER -