Small is beautiful: microRNAs and breast cancer-where are we now?

E T Verghese, A M Hanby, V Speirs, T A Hughes

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

MicroRNAs are a recently discovered class of small regulatory RNAs that influence the stability and translational efficiency of target mRNAs. They have been implicated in an increasing number of biological processes, including neoplasia. Recent studies have shown an involvement for these regulatory molecules in breast cancer. For example, miRNA profiling studies have identified microRNAs that are deregulated in breast cancer. Furthermore, functional studies have uncovered their roles in breast cancer as both tumour suppressor genes (eg miR-335) and oncogenes (eg miR-21). miRNAs deregulated in breast cancer influence the translational regulation of well-established regulatory molecules, such as oestrogen receptor-alpha, which is regulated by miR-206, and novel cancer-related molecules whose functions are not yet fully understood.. Here we present an overview of our current understanding of miRNA in breast cancer.

Original languageEnglish
Pages (from-to)214-21
Number of pages8
JournalThe Journal of pathology
Volume215
Issue number3
DOIs
Publication statusPublished - Jul 2008

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Keywords

  • Breast Neoplasms
  • Female
  • Gene Expression Regulation, Neoplastic
  • Gene Regulatory Networks
  • Genes, Tumor Suppressor
  • Humans
  • MicroRNAs
  • Oncogenes
  • RNA, Neoplasm
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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