Smoking predicts long-term mortality in stroke

The European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study

Phyo K Myint, Ailsa A Welch, Sheila A Bingham, Robert N Luben, Nicholas J Wareham, Nicholas E Day, Kay-Tee Khaw

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

BACKGROUND: : While the relationship between risk factors and stroke is well established, there is less information about the risk factors and survival after stroke. We examined the independent association between cardiovascular and modifiable lifestyle risk factors and subsequent mortality in people with stroke.

METHODS: : 308 free-living men and women with stroke at baseline survey in 1993-1997 participating in the European Prospective Investigation into Cancer (EPIC)-Norfolk were followed up for long-term mortality (average follow-up 7.5 years). Using Cox's proportional hazards model, we assessed the relationships between an individual's age, sex, cardiovascular risk profile including systolic blood pressure, body mass index, cholesterol, history of diabetes and lifestyle behaviors smoking and alcohol consumption and subsequent mortality up to July 2004.

RESULTS: : There were a total of 100 deaths during follow-up (total person years = 2318). Advancing age (RR 1.72, 95%CI: 1.42, 2.09) and current smoking (RR 2.27, 95%CI: 1.12, 4.57) predicted higher risk while female sex was associated with reduced risk (RR 0.51, 95%CI; 0.31, 0.84) of subsequent mortality after stroke independently of other risk factors investigated.

CONCLUSIONS: : Our findings may provide further empirical encouragement for smoking cessation after stroke.

Original languageEnglish
Pages (from-to)128-31
Number of pages4
JournalPreventive Medicine
Volume42
Issue number2
DOIs
Publication statusPublished - Feb 2006

Fingerprint

Smoking
Stroke
Prospective Studies
Mortality
Population
Neoplasms
Life Style
Blood Pressure
Smoking Cessation
Proportional Hazards Models
Alcohol Drinking
Body Mass Index
Cholesterol
Survival

Keywords

  • Adult
  • Aged
  • Female
  • Great Britain
  • Humans
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Smoking
  • Stroke

Cite this

Smoking predicts long-term mortality in stroke : The European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study. / Myint, Phyo K; Welch, Ailsa A; Bingham, Sheila A; Luben, Robert N; Wareham, Nicholas J; Day, Nicholas E; Khaw, Kay-Tee.

In: Preventive Medicine, Vol. 42, No. 2, 02.2006, p. 128-31.

Research output: Contribution to journalArticle

Myint, Phyo K ; Welch, Ailsa A ; Bingham, Sheila A ; Luben, Robert N ; Wareham, Nicholas J ; Day, Nicholas E ; Khaw, Kay-Tee. / Smoking predicts long-term mortality in stroke : The European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study. In: Preventive Medicine. 2006 ; Vol. 42, No. 2. pp. 128-31.
@article{98549ce36b9448a1be12d5d7fa605b60,
title = "Smoking predicts long-term mortality in stroke: The European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study",
abstract = "BACKGROUND: : While the relationship between risk factors and stroke is well established, there is less information about the risk factors and survival after stroke. We examined the independent association between cardiovascular and modifiable lifestyle risk factors and subsequent mortality in people with stroke.METHODS: : 308 free-living men and women with stroke at baseline survey in 1993-1997 participating in the European Prospective Investigation into Cancer (EPIC)-Norfolk were followed up for long-term mortality (average follow-up 7.5 years). Using Cox's proportional hazards model, we assessed the relationships between an individual's age, sex, cardiovascular risk profile including systolic blood pressure, body mass index, cholesterol, history of diabetes and lifestyle behaviors smoking and alcohol consumption and subsequent mortality up to July 2004.RESULTS: : There were a total of 100 deaths during follow-up (total person years = 2318). Advancing age (RR 1.72, 95{\%}CI: 1.42, 2.09) and current smoking (RR 2.27, 95{\%}CI: 1.12, 4.57) predicted higher risk while female sex was associated with reduced risk (RR 0.51, 95{\%}CI; 0.31, 0.84) of subsequent mortality after stroke independently of other risk factors investigated.CONCLUSIONS: : Our findings may provide further empirical encouragement for smoking cessation after stroke.",
keywords = "Adult, Aged, Female, Great Britain, Humans, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Risk Factors, Smoking, Stroke",
author = "Myint, {Phyo K} and Welch, {Ailsa A} and Bingham, {Sheila A} and Luben, {Robert N} and Wareham, {Nicholas J} and Day, {Nicholas E} and Kay-Tee Khaw",
year = "2006",
month = "2",
doi = "10.1016/j.ypmed.2005.11.014",
language = "English",
volume = "42",
pages = "128--31",
journal = "Preventive Medicine",
issn = "0091-7435",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Smoking predicts long-term mortality in stroke

T2 - The European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study

AU - Myint, Phyo K

AU - Welch, Ailsa A

AU - Bingham, Sheila A

AU - Luben, Robert N

AU - Wareham, Nicholas J

AU - Day, Nicholas E

AU - Khaw, Kay-Tee

PY - 2006/2

Y1 - 2006/2

N2 - BACKGROUND: : While the relationship between risk factors and stroke is well established, there is less information about the risk factors and survival after stroke. We examined the independent association between cardiovascular and modifiable lifestyle risk factors and subsequent mortality in people with stroke.METHODS: : 308 free-living men and women with stroke at baseline survey in 1993-1997 participating in the European Prospective Investigation into Cancer (EPIC)-Norfolk were followed up for long-term mortality (average follow-up 7.5 years). Using Cox's proportional hazards model, we assessed the relationships between an individual's age, sex, cardiovascular risk profile including systolic blood pressure, body mass index, cholesterol, history of diabetes and lifestyle behaviors smoking and alcohol consumption and subsequent mortality up to July 2004.RESULTS: : There were a total of 100 deaths during follow-up (total person years = 2318). Advancing age (RR 1.72, 95%CI: 1.42, 2.09) and current smoking (RR 2.27, 95%CI: 1.12, 4.57) predicted higher risk while female sex was associated with reduced risk (RR 0.51, 95%CI; 0.31, 0.84) of subsequent mortality after stroke independently of other risk factors investigated.CONCLUSIONS: : Our findings may provide further empirical encouragement for smoking cessation after stroke.

AB - BACKGROUND: : While the relationship between risk factors and stroke is well established, there is less information about the risk factors and survival after stroke. We examined the independent association between cardiovascular and modifiable lifestyle risk factors and subsequent mortality in people with stroke.METHODS: : 308 free-living men and women with stroke at baseline survey in 1993-1997 participating in the European Prospective Investigation into Cancer (EPIC)-Norfolk were followed up for long-term mortality (average follow-up 7.5 years). Using Cox's proportional hazards model, we assessed the relationships between an individual's age, sex, cardiovascular risk profile including systolic blood pressure, body mass index, cholesterol, history of diabetes and lifestyle behaviors smoking and alcohol consumption and subsequent mortality up to July 2004.RESULTS: : There were a total of 100 deaths during follow-up (total person years = 2318). Advancing age (RR 1.72, 95%CI: 1.42, 2.09) and current smoking (RR 2.27, 95%CI: 1.12, 4.57) predicted higher risk while female sex was associated with reduced risk (RR 0.51, 95%CI; 0.31, 0.84) of subsequent mortality after stroke independently of other risk factors investigated.CONCLUSIONS: : Our findings may provide further empirical encouragement for smoking cessation after stroke.

KW - Adult

KW - Aged

KW - Female

KW - Great Britain

KW - Humans

KW - Male

KW - Middle Aged

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk Factors

KW - Smoking

KW - Stroke

U2 - 10.1016/j.ypmed.2005.11.014

DO - 10.1016/j.ypmed.2005.11.014

M3 - Article

VL - 42

SP - 128

EP - 131

JO - Preventive Medicine

JF - Preventive Medicine

SN - 0091-7435

IS - 2

ER -