Sodium acetate induces a metabolic alkalosis but not the increase in fatty acid oxidation observed following bicarbonate ingestion in humans

Gordon I. Smith, Asker E. Jeukendrup, Derek Ball

Research output: Contribution to journalArticle

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Abstract

We conducted this study to quantify the oxidation of exogenous acetate and to determine the effect of increased acetate availability upon fat and carbohydrate utilization in humans at rest. Eight healthy volunteers (6 males and 2 females) completed 2 separate trials, 7 d apart in a single-blind, randomized, crossover design. On each occasion, respiratory gas and arterialized venous blood samples were taken before and during 180 min following consumption of a drink containing either sodium acetate (NaAc) or NaHCO3 at a dose of 2 mmol/kg body mass. Labeled [1,2-13C] NaAc was added to the NaAc drink to quantify acetate oxidation. Both sodium salts induced a mild metabolic alkalosis and increased energy expenditure (P < 0.05) to a similar magnitude. NaHCO3 ingestion increased fat utilization from 587 ± 83 kJ/180 min to 693 ± 101 kJ/180 min (P = 0.01) with no change in carbohydrate utilization. Following ingestion of NaAc, the amount of fat and carbohydrate utilized did not differ from the preingestion values. However, oxidation of the exogenous acetate almost entirely (90%) replaced the additional fat that had been oxidized during the bicarbonate trial. We determined that 80.1 ± 2.3% of an exogenous source of acetate is oxidized in humans at rest. Whereas NaHCO3 ingestion increased fat oxidation, a similar response did not occur following NaAc ingestion despite the fact both sodium salts induced a similar increase in energy expenditure and shift in acid-base balance.

Original languageEnglish
Pages (from-to)1750-1756
Number of pages7
JournalJournal of Nutrition
Volume137
Issue number7
DOIs
Publication statusPublished - Jul 2007

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Sodium Acetate
Alkalosis
Bicarbonates
Acetates
Fatty Acids
Eating
Fats
Carbohydrates
Energy Metabolism
Salts
Sodium
Acid-Base Equilibrium
Cross-Over Studies
Healthy Volunteers
Gases

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Sodium acetate induces a metabolic alkalosis but not the increase in fatty acid oxidation observed following bicarbonate ingestion in humans. / Smith, Gordon I.; Jeukendrup, Asker E.; Ball, Derek.

In: Journal of Nutrition, Vol. 137, No. 7, 07.2007, p. 1750-1756.

Research output: Contribution to journalArticle

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