Sperm penetration assay in predicting successful in vitro fertilization: A meta-analysis

Ben W.J. Mol; Saskia Meijer; Simone Yuppa; Erwin Tan; Jan De Vries; Patrick M.M. Bossuyt; Fulco Van Der Veen

Sperm penetration assay in predicting successful in vitro fertilization: A meta-analysis

Ben W.J. Mol^*, Saskia Meijer, Simone Yuppa, Erwin Tan, Jan De Vries, Patrick M.M. Bossuyt, Fulco Van Der Veen

^*Corresponding author for this work

Applied Health Sciences

University of Amsterdam

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

OBJECTIVE: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF). METHODS: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF. RESULTS: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity. CONCLUSION: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF embryo transfer.

Original language	English
Pages (from-to)	503-508
Number of pages	6
Journal	Journal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume	43
Issue number	6
Publication status	Published - 1 Jun 1998

Keywords

Fertilization, in vitro
Infertility, female
Meta-analysis
Sperm penetration

Cite this

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title = "Sperm penetration assay in predicting successful in vitro fertilization: A meta-analysis",

abstract = "OBJECTIVE: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF). METHODS: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF. RESULTS: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity. CONCLUSION: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF embryo transfer.",

keywords = "Fertilization, in vitro, Infertility, female, Meta-analysis, Sperm penetration",

author = "Mol, {Ben W.J.} and Saskia Meijer and Simone Yuppa and Erwin Tan and {De Vries}, Jan and Bossuyt, {Patrick M.M.} and {Van Der Veen}, Fulco",

year = "1998",

month = jun,

day = "1",

language = "English",

volume = "43",

pages = "503--508",

journal = "Journal of Reproductive Medicine for the Obstetrician and Gynecologist",

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TY - JOUR

T1 - Sperm penetration assay in predicting successful in vitro fertilization

T2 - A meta-analysis

AU - Mol, Ben W.J.

AU - Meijer, Saskia

AU - Yuppa, Simone

AU - Tan, Erwin

AU - De Vries, Jan

AU - Bossuyt, Patrick M.M.

AU - Van Der Veen, Fulco

PY - 1998/6/1

Y1 - 1998/6/1

N2 - OBJECTIVE: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF). METHODS: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF. RESULTS: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity. CONCLUSION: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF embryo transfer.

AB - OBJECTIVE: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF). METHODS: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF. RESULTS: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity. CONCLUSION: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF embryo transfer.

KW - Fertilization, in vitro

KW - Infertility, female

KW - Meta-analysis

KW - Sperm penetration

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AN - SCOPUS:0031842409

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JF - Journal of Reproductive Medicine for the Obstetrician and Gynecologist

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Sperm penetration assay in predicting successful in vitro fertilization: A meta-analysis

Abstract

Keywords

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