TY - JOUR
T1 - Spirometric phenotypes from early childhood to young adulthood
T2 - a Chronic Airway Disease Early Stratification study
AU - Wang, Gang
AU - Hallberg, Jenny
AU - Charalampopoulos, Dimitrios
AU - Sanahuja, Maribel Casas
AU - Breyer-Kohansal, Robab
AU - Langhammer, Arnulf
AU - Granell, Raquel
AU - Vonk, Judith M.
AU - Mian, Annemiek
AU - Olvera, Núria
AU - Laustsen, Lisbeth Mølgaard
AU - Rönmark, Eva
AU - Abellan, Alicia
AU - Agusti, Alvar
AU - Arshad, Syed Hasan
AU - Bergström, Anna
AU - Boezen, H. Marike
AU - Breyer, Marie Kathrin
AU - Burghuber, Otto
AU - Bolund, Anneli Clea
AU - Custovic, Adnan
AU - Devereux, Graham
AU - Donaldson, Gavin C.
AU - Duijts, Liesbeth
AU - Esplugues, Ana
AU - Faner, Rosa
AU - Ballester, Ferran
AU - Garcia-Aymerich, Judith
AU - Gehring, Ulrike
AU - Haider, Sadia
AU - Hartl, Sylvia
AU - Backman, Helena
AU - Holloway, John W.
AU - Koppelman, Gerard H.
AU - Lertxundi, Aitana
AU - Holmen, Turid Lingaas
AU - Lowe, Lesley
AU - Mensink-Bout, Sara M.
AU - Murray, Clare S.
AU - Roberts, Graham
AU - Hedman, Linnea
AU - Schlünssen, Vivi
AU - Sigsgaard, Torben
AU - Simpson, Angela
AU - Sunyer, Jordi
AU - Torrent, Maties
AU - Turner, Stephen
AU - Van den Berge, Maarten
AU - Vermeulen, Roel C.H.
AU - Vikjord, Sigrid Anna Aalberg
AU - CADSET Clinical Research Collaboration
N1 - Acknowledgements
Cohort-specific acknowledgements are presented in the supplementary material. We also acknowledge collaboration with the EXPANSE consortium (funded by the EU H2020 programme, grant number 874627). We thank Elise Heuvelin, European Respiratory Society, Lausanne, Switzerland, for her assistance on the current project.
PY - 2021/12/6
Y1 - 2021/12/6
N2 - Background The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts. Methods We studied 49334 participants from 14 population-based cohorts in different age groups (⩽10, >10–15, >15–20, >20–25 years, and overall, 5–25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ⩾LLN, and FVC z-score <LLN. Results The prevalence of obstructive and restrictive phenotypes varied from 3.2–10.9% and 1.8–7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14–3.04), preterm birth (aOR=1.84, 1.27–2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01–1.35) and family history of asthma (aOR=1.44, 95% CI 1.25–1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5–25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03–1.06 and aOR=0.81, 95% CI 0.78–0.85, per kg·m−2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05–1.46). Conclusion Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.
AB - Background The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts. Methods We studied 49334 participants from 14 population-based cohorts in different age groups (⩽10, >10–15, >15–20, >20–25 years, and overall, 5–25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ⩾LLN, and FVC z-score <LLN. Results The prevalence of obstructive and restrictive phenotypes varied from 3.2–10.9% and 1.8–7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14–3.04), preterm birth (aOR=1.84, 1.27–2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01–1.35) and family history of asthma (aOR=1.44, 95% CI 1.25–1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5–25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03–1.06 and aOR=0.81, 95% CI 0.78–0.85, per kg·m−2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05–1.46). Conclusion Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.
UR - http://www.scopus.com/inward/record.url?scp=85122250374&partnerID=8YFLogxK
U2 - 10.1183/23120541.00457-2021
DO - 10.1183/23120541.00457-2021
M3 - Article
AN - SCOPUS:85122250374
SN - 2312-0541
VL - 7
JO - ERJ Open Research
JF - ERJ Open Research
IS - 4
M1 - 00457
ER -