18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

Elisa Calamai, Sergio Dall'Angelo, David Koss, Juozas Domarkas, Timothy J McCarthy, Marco Mingarelli, Gernot Riedel, Lutz Frank Schweiger, Andrew Edward Welch, Bettina Platt, Matteo Zanda

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [18F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [18F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.
Original languageEnglish
Pages (from-to)792-794
Number of pages3
JournalChemical Communications
Volume49
Issue number8
Early online date4 Dec 2012
DOIs
Publication statusPublished - 2013

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