Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [18F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [18F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.
Calamai, E., Dall'Angelo, S., Koss, D., Domarkas, J., McCarthy, T. J., Mingarelli, M., Riedel, G., Schweiger, L. F., Welch, A. E., Platt, B., & Zanda, M. (2013). 18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease. Chemical Communications, 49(8), 792-794. https://doi.org/10.1039/C2CC38443D, https://doi.org/10.1039/c2cc38443d