The KefB and KefC systems of Escherichia coli cells are activated by iodoacetate (IOA) and chlorodinitrobenzene (CDNB), leading to a rapid drop in the intracellular pH. However, survival of exposure to IOA or CDNB was found to be essentially independent of KefB and KefC activation. No correlation was found between the toxicity of the compound and its ability to elicit protective acidification via activation of KefB and KefC.
|Number of pages||4|
|Journal||Applied and Environmental Microbiology|
|Publication status||Published - 1 Oct 1997|
- Bacterial Proteins
- Cell Division
- Escherichia coli
- Escherichia coli Proteins
- Hydrogen-Ion Concentration
- Iodoacetic Acid
- Ion Channel Gating
- Ion Transport
- Potassium Channels
- Potassium-Hydrogen Antiporters
Ness, L. S., Ferguson, G. P., Nikolaev, Y., & Booth, I. R. (1997). Survival of Escherichia coli cells exposed to iodoacetate and chlorodinitrobenzene is independent of the glutathione-gated K+ efflux systems KefB and KefC. Applied and Environmental Microbiology, 63(10), 4083-4086.