Survival of Escherichia coli cells exposed to iodoacetate and chlorodinitrobenzene is independent of the glutathione-gated K+ efflux systems KefB and KefC

L S Ness, Gail Patricia Ferguson, Y Nikolaev, Ian Rylance Booth

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The KefB and KefC systems of Escherichia coli cells are activated by iodoacetate (IOA) and chlorodinitrobenzene (CDNB), leading to a rapid drop in the intracellular pH. However, survival of exposure to IOA or CDNB was found to be essentially independent of KefB and KefC activation. No correlation was found between the toxicity of the compound and its ability to elicit protective acidification via activation of KefB and KefC.
Original languageEnglish
Pages (from-to)4083-4086
Number of pages4
JournalApplied and Environmental Microbiology
Volume63
Issue number10
Publication statusPublished - 1 Oct 1997

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Iodoacetates
Dinitrochlorobenzene
acidification
Glutathione
glutathione
Escherichia coli
toxicity
cells
exposure

Keywords

  • Antiporters
  • Bacterial Proteins
  • Cell Division
  • Dinitrochlorobenzene
  • Escherichia coli
  • Escherichia coli Proteins
  • Glutathione
  • Hydrogen-Ion Concentration
  • Iodoacetates
  • Iodoacetic Acid
  • Ion Channel Gating
  • Ion Transport
  • Potassium Channels
  • Potassium-Hydrogen Antiporters

Cite this

Survival of Escherichia coli cells exposed to iodoacetate and chlorodinitrobenzene is independent of the glutathione-gated K+ efflux systems KefB and KefC. / Ness, L S; Ferguson, Gail Patricia; Nikolaev, Y; Booth, Ian Rylance.

In: Applied and Environmental Microbiology, Vol. 63, No. 10, 01.10.1997, p. 4083-4086.

Research output: Contribution to journalArticle

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abstract = "The KefB and KefC systems of Escherichia coli cells are activated by iodoacetate (IOA) and chlorodinitrobenzene (CDNB), leading to a rapid drop in the intracellular pH. However, survival of exposure to IOA or CDNB was found to be essentially independent of KefB and KefC activation. No correlation was found between the toxicity of the compound and its ability to elicit protective acidification via activation of KefB and KefC.",
keywords = "Antiporters, Bacterial Proteins, Cell Division, Dinitrochlorobenzene, Escherichia coli, Escherichia coli Proteins, Glutathione, Hydrogen-Ion Concentration, Iodoacetates, Iodoacetic Acid, Ion Channel Gating, Ion Transport, Potassium Channels, Potassium-Hydrogen Antiporters",
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AU - Ness, L S

AU - Ferguson, Gail Patricia

AU - Nikolaev, Y

AU - Booth, Ian Rylance

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N2 - The KefB and KefC systems of Escherichia coli cells are activated by iodoacetate (IOA) and chlorodinitrobenzene (CDNB), leading to a rapid drop in the intracellular pH. However, survival of exposure to IOA or CDNB was found to be essentially independent of KefB and KefC activation. No correlation was found between the toxicity of the compound and its ability to elicit protective acidification via activation of KefB and KefC.

AB - The KefB and KefC systems of Escherichia coli cells are activated by iodoacetate (IOA) and chlorodinitrobenzene (CDNB), leading to a rapid drop in the intracellular pH. However, survival of exposure to IOA or CDNB was found to be essentially independent of KefB and KefC activation. No correlation was found between the toxicity of the compound and its ability to elicit protective acidification via activation of KefB and KefC.

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KW - Bacterial Proteins

KW - Cell Division

KW - Dinitrochlorobenzene

KW - Escherichia coli

KW - Escherichia coli Proteins

KW - Glutathione

KW - Hydrogen-Ion Concentration

KW - Iodoacetates

KW - Iodoacetic Acid

KW - Ion Channel Gating

KW - Ion Transport

KW - Potassium Channels

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