Survival of Escherichia coli cells exposed to iodoacetate and chlorodinitrobenzene is independent of the glutathione-gated K+ efflux systems KefB and KefC

L S Ness, Gail Patricia Ferguson, Y Nikolaev, Ian Rylance Booth

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The KefB and KefC systems of Escherichia coli cells are activated by iodoacetate (IOA) and chlorodinitrobenzene (CDNB), leading to a rapid drop in the intracellular pH. However, survival of exposure to IOA or CDNB was found to be essentially independent of KefB and KefC activation. No correlation was found between the toxicity of the compound and its ability to elicit protective acidification via activation of KefB and KefC.
Original languageEnglish
Pages (from-to)4083-4086
Number of pages4
JournalApplied and Environmental Microbiology
Issue number10
Publication statusPublished - 1 Oct 1997



  • Antiporters
  • Bacterial Proteins
  • Cell Division
  • Dinitrochlorobenzene
  • Escherichia coli
  • Escherichia coli Proteins
  • Glutathione
  • Hydrogen-Ion Concentration
  • Iodoacetates
  • Iodoacetic Acid
  • Ion Channel Gating
  • Ion Transport
  • Potassium Channels
  • Potassium-Hydrogen Antiporters

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