Survival of Escherichia coli cells exposed to iodoacetate and chlorodinitrobenzene is independent of the glutathione-gated K+ efflux systems KefB and KefC

L S Ness; Gail Patricia Ferguson; Y Nikolaev; Ian Rylance Booth

Survival of Escherichia coli cells exposed to iodoacetate and chlorodinitrobenzene is independent of the glutathione-gated K+ efflux systems KefB and KefC

L S Ness, Gail Patricia Ferguson, Y Nikolaev, Ian Rylance Booth

Research output: Contribution to journal › Article › peer-review

Abstract

The KefB and KefC systems of Escherichia coli cells are activated by iodoacetate (IOA) and chlorodinitrobenzene (CDNB), leading to a rapid drop in the intracellular pH. However, survival of exposure to IOA or CDNB was found to be essentially independent of KefB and KefC activation. No correlation was found between the toxicity of the compound and its ability to elicit protective acidification via activation of KefB and KefC.

Original language	English
Pages (from-to)	4083-4086
Number of pages	4
Journal	Applied and Environmental Microbiology
Volume	63
Issue number	10
Publication status	Published - 1 Oct 1997

Keywords

Antiporters
Bacterial Proteins
Cell Division
Dinitrochlorobenzene
Escherichia coli
Escherichia coli Proteins
Glutathione
Hydrogen-Ion Concentration
Iodoacetates
Iodoacetic Acid
Ion Channel Gating
Ion Transport
Potassium Channels
Potassium-Hydrogen Antiporters

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@article{1aca1bdadbe848daa70bd95afe10642b,

title = "Survival of Escherichia coli cells exposed to iodoacetate and chlorodinitrobenzene is independent of the glutathione-gated K+ efflux systems KefB and KefC",

abstract = "The KefB and KefC systems of Escherichia coli cells are activated by iodoacetate (IOA) and chlorodinitrobenzene (CDNB), leading to a rapid drop in the intracellular pH. However, survival of exposure to IOA or CDNB was found to be essentially independent of KefB and KefC activation. No correlation was found between the toxicity of the compound and its ability to elicit protective acidification via activation of KefB and KefC.",

keywords = "Antiporters, Bacterial Proteins, Cell Division, Dinitrochlorobenzene, Escherichia coli, Escherichia coli Proteins, Glutathione, Hydrogen-Ion Concentration, Iodoacetates, Iodoacetic Acid, Ion Channel Gating, Ion Transport, Potassium Channels, Potassium-Hydrogen Antiporters",

author = "Ness, {L S} and Ferguson, {Gail Patricia} and Y Nikolaev and Booth, {Ian Rylance}",

year = "1997",

month = oct,

day = "1",

language = "English",

volume = "63",

pages = "4083--4086",

journal = "Applied and Environmental Microbiology",

issn = "0099-2240",

publisher = "American Society for Microbiology",

number = "10",

}

TY - JOUR

T1 - Survival of Escherichia coli cells exposed to iodoacetate and chlorodinitrobenzene is independent of the glutathione-gated K+ efflux systems KefB and KefC

AU - Ness, L S

AU - Ferguson, Gail Patricia

AU - Nikolaev, Y

AU - Booth, Ian Rylance

PY - 1997/10/1

Y1 - 1997/10/1

N2 - The KefB and KefC systems of Escherichia coli cells are activated by iodoacetate (IOA) and chlorodinitrobenzene (CDNB), leading to a rapid drop in the intracellular pH. However, survival of exposure to IOA or CDNB was found to be essentially independent of KefB and KefC activation. No correlation was found between the toxicity of the compound and its ability to elicit protective acidification via activation of KefB and KefC.

AB - The KefB and KefC systems of Escherichia coli cells are activated by iodoacetate (IOA) and chlorodinitrobenzene (CDNB), leading to a rapid drop in the intracellular pH. However, survival of exposure to IOA or CDNB was found to be essentially independent of KefB and KefC activation. No correlation was found between the toxicity of the compound and its ability to elicit protective acidification via activation of KefB and KefC.

KW - Antiporters

KW - Bacterial Proteins

KW - Cell Division

KW - Dinitrochlorobenzene

KW - Escherichia coli

KW - Escherichia coli Proteins

KW - Glutathione

KW - Hydrogen-Ion Concentration

KW - Iodoacetates

KW - Iodoacetic Acid

KW - Ion Channel Gating

KW - Ion Transport

KW - Potassium Channels

KW - Potassium-Hydrogen Antiporters

M3 - Article

C2 - 9327573

SN - 0099-2240

VL - 63

SP - 4083

EP - 4086

JO - Applied and Environmental Microbiology

JF - Applied and Environmental Microbiology

IS - 10

ER -

Survival of Escherichia coli cells exposed to iodoacetate and chlorodinitrobenzene is independent of the glutathione-gated K+ efflux systems KefB and KefC

Abstract

Keywords

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