Synthesis and characterisation of strontium and magnesium co-substituted biphasic calcium phosphates

Flora E. Imrie*, Valentina Aina, Gigliola Lusvardi, Gianluca Malavasi, Iain R. Gibson, Giuseppina Cerrato, Basil Annaz

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Magnesium and strontium both play important roles in the growth of bone and so are desirable ions for substitution into hydroxyapatite (HA) intended for use as bioinstructive bone substitutes. A range of compositions were prepared by a solid state method based on the nominal composition of HA (Ca 10(PO4)6(OH)2), with various levels of strontium and/or magnesium substitution: strontium-substituted HA (Ca 8Sr2(PO4)6(OH)2), magnesium-substituted HA (Ca9.8Mg0.2(PO4) 6(OH)2 and Ca9Mg(PO4)6(OH) 2), and strontium and magnesium co-substituted HA (Ca 7.8Sr2Mg0.2(PO4)6(OH) 2 and Ca7Sr2Mg(PO4) 6(OH)2). Materials were characterised by powder X-ray diffraction, Fourier-transform infrared spectroscopy and Raman spectroscopy. These analyses indicated that the co-substituted materials were composed of mixtures of strontium-substituted hydroxyapatite and magnesium and strontium co-substituted β-tricalcium phosphate. In the magnesium-substituted materials, increased magnesium content was related to increased proportion of β-tricalcium phosphate phase, both with and without strontium co-substitution. The unsubstituted and strontium mono-substituted materials, however, were pure apatite phase, suggesting that magnesium was the destabilising factor in the phase compositions of the magnesium mono-substituted and magnesium and strontium co-substituted materials.

Original languageEnglish
Title of host publicationBioceramics 24
Pages88-93
Number of pages6
Edition1
DOIs
Publication statusPublished - 1 Jan 2013
Event24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, Japan
Duration: 21 Oct 201224 Oct 2012

Publication series

NameKey Engineering Materials
Number1
Volume529-530
ISSN (Print)1013-9826

Conference

Conference24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
CountryJapan
CityFukuoka
Period21/10/1224/10/12

Fingerprint

Strontium
Calcium phosphate
Magnesium
Durapatite
Hydroxyapatite
Substitution reactions
Bone
Phosphates
hydroxyapatite-beta tricalcium phosphate
Bone Substitutes
Apatites
Apatite
Chemical analysis
Phase composition
X ray powder diffraction
Fourier transform infrared spectroscopy
Raman spectroscopy
Ions

Keywords

  • Beta-tricalcium phosphate
  • Biphasic calcium phosphates
  • Hydroxyapatite
  • Magnesium
  • Rietveld refinement
  • Solid state synthesis
  • Strontium

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Imrie, F. E., Aina, V., Lusvardi, G., Malavasi, G., Gibson, I. R., Cerrato, G., & Annaz, B. (2013). Synthesis and characterisation of strontium and magnesium co-substituted biphasic calcium phosphates. In Bioceramics 24 (1 ed., pp. 88-93). (Key Engineering Materials; Vol. 529-530, No. 1). https://doi.org/10.4028/www.scientific.net/KEM.529-530.88

Synthesis and characterisation of strontium and magnesium co-substituted biphasic calcium phosphates. / Imrie, Flora E.; Aina, Valentina; Lusvardi, Gigliola; Malavasi, Gianluca; Gibson, Iain R.; Cerrato, Giuseppina; Annaz, Basil.

Bioceramics 24. 1. ed. 2013. p. 88-93 (Key Engineering Materials; Vol. 529-530, No. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Imrie, FE, Aina, V, Lusvardi, G, Malavasi, G, Gibson, IR, Cerrato, G & Annaz, B 2013, Synthesis and characterisation of strontium and magnesium co-substituted biphasic calcium phosphates. in Bioceramics 24. 1 edn, Key Engineering Materials, no. 1, vol. 529-530, pp. 88-93, 24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012, Fukuoka, Japan, 21/10/12. https://doi.org/10.4028/www.scientific.net/KEM.529-530.88
Imrie FE, Aina V, Lusvardi G, Malavasi G, Gibson IR, Cerrato G et al. Synthesis and characterisation of strontium and magnesium co-substituted biphasic calcium phosphates. In Bioceramics 24. 1 ed. 2013. p. 88-93. (Key Engineering Materials; 1). https://doi.org/10.4028/www.scientific.net/KEM.529-530.88
Imrie, Flora E. ; Aina, Valentina ; Lusvardi, Gigliola ; Malavasi, Gianluca ; Gibson, Iain R. ; Cerrato, Giuseppina ; Annaz, Basil. / Synthesis and characterisation of strontium and magnesium co-substituted biphasic calcium phosphates. Bioceramics 24. 1. ed. 2013. pp. 88-93 (Key Engineering Materials; 1).
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N2 - Magnesium and strontium both play important roles in the growth of bone and so are desirable ions for substitution into hydroxyapatite (HA) intended for use as bioinstructive bone substitutes. A range of compositions were prepared by a solid state method based on the nominal composition of HA (Ca 10(PO4)6(OH)2), with various levels of strontium and/or magnesium substitution: strontium-substituted HA (Ca 8Sr2(PO4)6(OH)2), magnesium-substituted HA (Ca9.8Mg0.2(PO4) 6(OH)2 and Ca9Mg(PO4)6(OH) 2), and strontium and magnesium co-substituted HA (Ca 7.8Sr2Mg0.2(PO4)6(OH) 2 and Ca7Sr2Mg(PO4) 6(OH)2). Materials were characterised by powder X-ray diffraction, Fourier-transform infrared spectroscopy and Raman spectroscopy. These analyses indicated that the co-substituted materials were composed of mixtures of strontium-substituted hydroxyapatite and magnesium and strontium co-substituted β-tricalcium phosphate. In the magnesium-substituted materials, increased magnesium content was related to increased proportion of β-tricalcium phosphate phase, both with and without strontium co-substitution. The unsubstituted and strontium mono-substituted materials, however, were pure apatite phase, suggesting that magnesium was the destabilising factor in the phase compositions of the magnesium mono-substituted and magnesium and strontium co-substituted materials.

AB - Magnesium and strontium both play important roles in the growth of bone and so are desirable ions for substitution into hydroxyapatite (HA) intended for use as bioinstructive bone substitutes. A range of compositions were prepared by a solid state method based on the nominal composition of HA (Ca 10(PO4)6(OH)2), with various levels of strontium and/or magnesium substitution: strontium-substituted HA (Ca 8Sr2(PO4)6(OH)2), magnesium-substituted HA (Ca9.8Mg0.2(PO4) 6(OH)2 and Ca9Mg(PO4)6(OH) 2), and strontium and magnesium co-substituted HA (Ca 7.8Sr2Mg0.2(PO4)6(OH) 2 and Ca7Sr2Mg(PO4) 6(OH)2). Materials were characterised by powder X-ray diffraction, Fourier-transform infrared spectroscopy and Raman spectroscopy. These analyses indicated that the co-substituted materials were composed of mixtures of strontium-substituted hydroxyapatite and magnesium and strontium co-substituted β-tricalcium phosphate. In the magnesium-substituted materials, increased magnesium content was related to increased proportion of β-tricalcium phosphate phase, both with and without strontium co-substitution. The unsubstituted and strontium mono-substituted materials, however, were pure apatite phase, suggesting that magnesium was the destabilising factor in the phase compositions of the magnesium mono-substituted and magnesium and strontium co-substituted materials.

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