Synthesis and characterisation of strontium and magnesium co-substituted biphasic calcium phosphates

Flora E. Imrie*, Valentina Aina, Gigliola Lusvardi, Gianluca Malavasi, Iain R. Gibson, Giuseppina Cerrato, Basil Annaz

*Corresponding author for this work

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8 Citations (Scopus)

Abstract

Magnesium and strontium both play important roles in the growth of bone and so are desirable ions for substitution into hydroxyapatite (HA) intended for use as bioinstructive bone substitutes. A range of compositions were prepared by a solid state method based on the nominal composition of HA (Ca 10(PO4)6(OH)2), with various levels of strontium and/or magnesium substitution: strontium-substituted HA (Ca 8Sr2(PO4)6(OH)2), magnesium-substituted HA (Ca9.8Mg0.2(PO4) 6(OH)2 and Ca9Mg(PO4)6(OH) 2), and strontium and magnesium co-substituted HA (Ca 7.8Sr2Mg0.2(PO4)6(OH) 2 and Ca7Sr2Mg(PO4) 6(OH)2). Materials were characterised by powder X-ray diffraction, Fourier-transform infrared spectroscopy and Raman spectroscopy. These analyses indicated that the co-substituted materials were composed of mixtures of strontium-substituted hydroxyapatite and magnesium and strontium co-substituted β-tricalcium phosphate. In the magnesium-substituted materials, increased magnesium content was related to increased proportion of β-tricalcium phosphate phase, both with and without strontium co-substitution. The unsubstituted and strontium mono-substituted materials, however, were pure apatite phase, suggesting that magnesium was the destabilising factor in the phase compositions of the magnesium mono-substituted and magnesium and strontium co-substituted materials.

Original languageEnglish
Title of host publicationBioceramics 24
Pages88-93
Number of pages6
Edition1
DOIs
Publication statusPublished - 1 Jan 2013
Event24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, Japan
Duration: 21 Oct 201224 Oct 2012

Publication series

NameKey Engineering Materials
Number1
Volume529-530
ISSN (Print)1013-9826

Conference

Conference24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
CountryJapan
CityFukuoka
Period21/10/1224/10/12

Keywords

  • Beta-tricalcium phosphate
  • Biphasic calcium phosphates
  • Hydroxyapatite
  • Magnesium
  • Rietveld refinement
  • Solid state synthesis
  • Strontium

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    Imrie, F. E., Aina, V., Lusvardi, G., Malavasi, G., Gibson, I. R., Cerrato, G., & Annaz, B. (2013). Synthesis and characterisation of strontium and magnesium co-substituted biphasic calcium phosphates. In Bioceramics 24 (1 ed., pp. 88-93). (Key Engineering Materials; Vol. 529-530, No. 1). https://doi.org/10.4028/www.scientific.net/KEM.529-530.88