TY - GEN
T1 - Synthesis and characterisation of strontium and magnesium co-substituted biphasic calcium phosphates
AU - Imrie, Flora E.
AU - Aina, Valentina
AU - Lusvardi, Gigliola
AU - Malavasi, Gianluca
AU - Gibson, Iain R.
AU - Cerrato, Giuseppina
AU - Annaz, Basil
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Magnesium and strontium both play important roles in the growth of bone and so are desirable ions for substitution into hydroxyapatite (HA) intended for use as bioinstructive bone substitutes. A range of compositions were prepared by a solid state method based on the nominal composition of HA (Ca 10(PO4)6(OH)2), with various levels of strontium and/or magnesium substitution: strontium-substituted HA (Ca 8Sr2(PO4)6(OH)2), magnesium-substituted HA (Ca9.8Mg0.2(PO4) 6(OH)2 and Ca9Mg(PO4)6(OH) 2), and strontium and magnesium co-substituted HA (Ca 7.8Sr2Mg0.2(PO4)6(OH) 2 and Ca7Sr2Mg(PO4) 6(OH)2). Materials were characterised by powder X-ray diffraction, Fourier-transform infrared spectroscopy and Raman spectroscopy. These analyses indicated that the co-substituted materials were composed of mixtures of strontium-substituted hydroxyapatite and magnesium and strontium co-substituted β-tricalcium phosphate. In the magnesium-substituted materials, increased magnesium content was related to increased proportion of β-tricalcium phosphate phase, both with and without strontium co-substitution. The unsubstituted and strontium mono-substituted materials, however, were pure apatite phase, suggesting that magnesium was the destabilising factor in the phase compositions of the magnesium mono-substituted and magnesium and strontium co-substituted materials.
AB - Magnesium and strontium both play important roles in the growth of bone and so are desirable ions for substitution into hydroxyapatite (HA) intended for use as bioinstructive bone substitutes. A range of compositions were prepared by a solid state method based on the nominal composition of HA (Ca 10(PO4)6(OH)2), with various levels of strontium and/or magnesium substitution: strontium-substituted HA (Ca 8Sr2(PO4)6(OH)2), magnesium-substituted HA (Ca9.8Mg0.2(PO4) 6(OH)2 and Ca9Mg(PO4)6(OH) 2), and strontium and magnesium co-substituted HA (Ca 7.8Sr2Mg0.2(PO4)6(OH) 2 and Ca7Sr2Mg(PO4) 6(OH)2). Materials were characterised by powder X-ray diffraction, Fourier-transform infrared spectroscopy and Raman spectroscopy. These analyses indicated that the co-substituted materials were composed of mixtures of strontium-substituted hydroxyapatite and magnesium and strontium co-substituted β-tricalcium phosphate. In the magnesium-substituted materials, increased magnesium content was related to increased proportion of β-tricalcium phosphate phase, both with and without strontium co-substitution. The unsubstituted and strontium mono-substituted materials, however, were pure apatite phase, suggesting that magnesium was the destabilising factor in the phase compositions of the magnesium mono-substituted and magnesium and strontium co-substituted materials.
KW - Beta-tricalcium phosphate
KW - Biphasic calcium phosphates
KW - Hydroxyapatite
KW - Magnesium
KW - Rietveld refinement
KW - Solid state synthesis
KW - Strontium
UR - http://www.scopus.com/inward/record.url?scp=84871280895&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/KEM.529-530.88
DO - 10.4028/www.scientific.net/KEM.529-530.88
M3 - Published conference contribution
AN - SCOPUS:84871280895
SN - 9783037855171
T3 - Key Engineering Materials
SP - 88
EP - 93
BT - Bioceramics 24
T2 - 24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
Y2 - 21 October 2012 through 24 October 2012
ER -