Here we show that enkephalin analogues with the Gly 3–Phe 4 peptide bond replaced by a stereochemically defined trifluoroethylamine function display binding affinities in the nanomolar range for the μ- and δ-opioid receptors, only 30- to 80-fold lower than those of the natural compounds, whereas the Gly 2–Gly 3 trifluoroethylamine analogues have lower affinity.
|Number of pages||5|
|Early online date||16 Jun 2009|
|Publication status||Published - 4 Sep 2009|
- amino acid sequence
- receptors, opioid