Abstract
5alpha-Androst-16-en-3-one has been prepared from 5alpha-androstane-7,17-dione in a five-step sequence, via selective ketalisation at C-7 with bis-trimethylsilyloxyethane and trimethylsilyl triflate as the key step, followed by introduction of the Delta(16) bond by reaction of the 17-hydrazone with iodine to give the vinyl iodide, and deiodination with sodium in ethanol, with acid-catalysed deprotection of the 7-oxo group as the final step. The compound has a mild sandalwood odour. (C) 200 Elsevier Science Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 9559-9560 |
Number of pages | 1 |
Journal | Tetrahedron Letters |
Volume | 43 |
DOIs | |
Publication status | Published - 2002 |