TY - JOUR
T1 - Synthesis, crystal structure and biological activity of a cobalt(II) complex of N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine
AU - Akhtar, Muhammad Nadeem
AU - Harrison, William T A
AU - Shahid, Muhammad
AU - Khan, Islam Ullah
AU - Ejaz, null
AU - Iqbal, Javed
N1 - Supplementary material
CCDC1025470 contains the supplementary crystallographic data for 1. These data can be obtained free of charge from the Cambridge Crystallographic Data Centre viawww.ccdc.cam.ac.uk/data_request/cif; supplementary materials associated with this article and crystallographic data (Table 1) can be found in the online version at doi:10.1007/s11243-016-0025-8.
PY - 2016/4
Y1 - 2016/4
N2 - The synthesis, crystal structure and biological properties of [Co(edtp)Cl)]·NO3·H2O are described, where edtp is N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine. The Co2+ ion is coordinated by the N,N′,O,O′,O″-pentadentate edtp ligand and a chloride to generate a distorted CoClN2O3 octahedron. The complex exhibits moderate antithrombolytic activity (38 % screened by hemolytic assay) against clots developed by bovine blood and negligible cytotoxicity (5 %) against bovine erythrocytes. Conversely, very high bacterial biofilm inhibition (90 %) was recorded against both Gram-positive and Gram-negative bacterial species.
AB - The synthesis, crystal structure and biological properties of [Co(edtp)Cl)]·NO3·H2O are described, where edtp is N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine. The Co2+ ion is coordinated by the N,N′,O,O′,O″-pentadentate edtp ligand and a chloride to generate a distorted CoClN2O3 octahedron. The complex exhibits moderate antithrombolytic activity (38 % screened by hemolytic assay) against clots developed by bovine blood and negligible cytotoxicity (5 %) against bovine erythrocytes. Conversely, very high bacterial biofilm inhibition (90 %) was recorded against both Gram-positive and Gram-negative bacterial species.
UR - http://www.scopus.com/inward/record.url?scp=84961286658&partnerID=8YFLogxK
U2 - 10.1007/s11243-016-0025-8
DO - 10.1007/s11243-016-0025-8
M3 - Article
AN - SCOPUS:84961286658
VL - 41
SP - 325
EP - 330
JO - Transition Metal Chemistry
JF - Transition Metal Chemistry
SN - 0340-4285
IS - 3
ER -