Synthesis, crystal structure and biological activity of a cobalt(II) complex of N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine

Muhammad Nadeem Akhtar; William T A Harrison; Muhammad Shahid; Islam Ullah Khan; null Ejaz; Javed Iqbal

doi:10.1007/s11243-016-0025-8

Synthesis, crystal structure and biological activity of a cobalt(II) complex of N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine

Muhammad Nadeem Akhtar^*, William T A Harrison, Muhammad Shahid, Islam Ullah Khan, Ejaz, Javed Iqbal

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The synthesis, crystal structure and biological properties of [Co(edtp)Cl)]·NO₃·H₂O are described, where edtp is N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine. The Co²⁺ ion is coordinated by the N,N′,O,O′,O″-pentadentate edtp ligand and a chloride to generate a distorted CoClN₂O₃ octahedron. The complex exhibits moderate antithrombolytic activity (38 % screened by hemolytic assay) against clots developed by bovine blood and negligible cytotoxicity (5 %) against bovine erythrocytes. Conversely, very high bacterial biofilm inhibition (90 %) was recorded against both Gram-positive and Gram-negative bacterial species.

Original language	English
Pages (from-to)	325-330
Number of pages	6
Journal	Transition Metal Chemistry
Volume	41
Issue number	3
Early online date	4 Feb 2016
DOIs	https://doi.org/10.1007/s11243-016-0025-8
Publication status	Published - Apr 2016

Bibliographical note

Supplementary material
CCDC1025470 contains the supplementary crystallographic data for 1. These data can be obtained free of charge from the Cambridge Crystallographic Data Centre viawww.ccdc.cam.ac.uk/data_request/cif; supplementary materials associated with this article and crystallographic data (Table 1) can be found in the online version at doi:10.1007/s11243-016-0025-8.

Access to Document

10.1007/s11243-016-0025-8Licence: Unspecified

Cite this

@article{56a58afac9dd45b6ba91fb9191db290c,

title = "Synthesis, crystal structure and biological activity of a cobalt(II) complex of N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine",

abstract = "The synthesis, crystal structure and biological properties of [Co(edtp)Cl)]·NO3·H2O are described, where edtp is N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine. The Co2+ ion is coordinated by the N,N′,O,O′,O″-pentadentate edtp ligand and a chloride to generate a distorted CoClN2O3 octahedron. The complex exhibits moderate antithrombolytic activity (38 % screened by hemolytic assay) against clots developed by bovine blood and negligible cytotoxicity (5 %) against bovine erythrocytes. Conversely, very high bacterial biofilm inhibition (90 %) was recorded against both Gram-positive and Gram-negative bacterial species.",

author = "Akhtar, {Muhammad Nadeem} and Harrison, {William T A} and Muhammad Shahid and Khan, {Islam Ullah} and Ejaz and Javed Iqbal",

note = "Supplementary material CCDC1025470 contains the supplementary crystallographic data for 1. These data can be obtained free of charge from the Cambridge Crystallographic Data Centre viawww.ccdc.cam.ac.uk/data_request/cif; supplementary materials associated with this article and crystallographic data (Table 1) can be found in the online version at doi:10.1007/s11243-016-0025-8.",

year = "2016",

month = apr,

doi = "10.1007/s11243-016-0025-8",

language = "English",

volume = "41",

pages = "325--330",

journal = "Transition Metal Chemistry",

issn = "0340-4285",

publisher = "Springer Netherlands",

number = "3",

}

TY - JOUR

T1 - Synthesis, crystal structure and biological activity of a cobalt(II) complex of N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine

AU - Akhtar, Muhammad Nadeem

AU - Harrison, William T A

AU - Shahid, Muhammad

AU - Khan, Islam Ullah

AU - Ejaz, null

AU - Iqbal, Javed

N1 - Supplementary material CCDC1025470 contains the supplementary crystallographic data for 1. These data can be obtained free of charge from the Cambridge Crystallographic Data Centre viawww.ccdc.cam.ac.uk/data_request/cif; supplementary materials associated with this article and crystallographic data (Table 1) can be found in the online version at doi:10.1007/s11243-016-0025-8.

PY - 2016/4

Y1 - 2016/4

N2 - The synthesis, crystal structure and biological properties of [Co(edtp)Cl)]·NO3·H2O are described, where edtp is N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine. The Co2+ ion is coordinated by the N,N′,O,O′,O″-pentadentate edtp ligand and a chloride to generate a distorted CoClN2O3 octahedron. The complex exhibits moderate antithrombolytic activity (38 % screened by hemolytic assay) against clots developed by bovine blood and negligible cytotoxicity (5 %) against bovine erythrocytes. Conversely, very high bacterial biofilm inhibition (90 %) was recorded against both Gram-positive and Gram-negative bacterial species.

AB - The synthesis, crystal structure and biological properties of [Co(edtp)Cl)]·NO3·H2O are described, where edtp is N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine. The Co2+ ion is coordinated by the N,N′,O,O′,O″-pentadentate edtp ligand and a chloride to generate a distorted CoClN2O3 octahedron. The complex exhibits moderate antithrombolytic activity (38 % screened by hemolytic assay) against clots developed by bovine blood and negligible cytotoxicity (5 %) against bovine erythrocytes. Conversely, very high bacterial biofilm inhibition (90 %) was recorded against both Gram-positive and Gram-negative bacterial species.

UR - http://www.scopus.com/inward/record.url?scp=84961286658&partnerID=8YFLogxK

U2 - 10.1007/s11243-016-0025-8

DO - 10.1007/s11243-016-0025-8

M3 - Article

AN - SCOPUS:84961286658

SN - 0340-4285

VL - 41

SP - 325

EP - 330

JO - Transition Metal Chemistry

JF - Transition Metal Chemistry

IS - 3

ER -

Synthesis, crystal structure and biological activity of a cobalt(II) complex of N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this