Synthesis, crystal structure and biological activity of a cobalt(II) complex of N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine

Muhammad Nadeem Akhtar*, William T A Harrison, Muhammad Shahid, Islam Ullah Khan, Ejaz, Javed Iqbal

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The synthesis, crystal structure and biological properties of [Co(edtp)Cl)]·NO3·H2O are described, where edtp is N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine. The Co2+ ion is coordinated by the N,N′,O,O′,O″-pentadentate edtp ligand and a chloride to generate a distorted CoClN2O3 octahedron. The complex exhibits moderate antithrombolytic activity (38 % screened by hemolytic assay) against clots developed by bovine blood and negligible cytotoxicity (5 %) against bovine erythrocytes. Conversely, very high bacterial biofilm inhibition (90 %) was recorded against both Gram-positive and Gram-negative bacterial species.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalTransition Metal Chemistry
Volume41
Issue number3
Early online date4 Feb 2016
DOIs
Publication statusPublished - Apr 2016

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ethylenediamine
Biofilms
Cytotoxicity
Cobalt
Bioactivity
Chlorides
Assays
Blood
Crystal structure
Ligands
Ions

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Materials Chemistry
  • Metals and Alloys

Cite this

Synthesis, crystal structure and biological activity of a cobalt(II) complex of N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine. / Akhtar, Muhammad Nadeem; Harrison, William T A; Shahid, Muhammad; Khan, Islam Ullah; Ejaz; Iqbal, Javed.

In: Transition Metal Chemistry, Vol. 41, No. 3, 04.2016, p. 325-330.

Research output: Contribution to journalArticle

Akhtar, Muhammad Nadeem ; Harrison, William T A ; Shahid, Muhammad ; Khan, Islam Ullah ; Ejaz ; Iqbal, Javed. / Synthesis, crystal structure and biological activity of a cobalt(II) complex of N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine. In: Transition Metal Chemistry. 2016 ; Vol. 41, No. 3. pp. 325-330.
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abstract = "The synthesis, crystal structure and biological properties of [Co(edtp)Cl)]·NO3·H2O are described, where edtp is N,N,N′,N′-tetrakis(2-hydroxypropyl) ethylenediamine. The Co2+ ion is coordinated by the N,N′,O,O′,O″-pentadentate edtp ligand and a chloride to generate a distorted CoClN2O3 octahedron. The complex exhibits moderate antithrombolytic activity (38 {\%} screened by hemolytic assay) against clots developed by bovine blood and negligible cytotoxicity (5 {\%}) against bovine erythrocytes. Conversely, very high bacterial biofilm inhibition (90 {\%}) was recorded against both Gram-positive and Gram-negative bacterial species.",
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