Abstract
This critical review aims at presenting recent developments in intramolecular aromatic homolytic substitution which has become one of the common methodologies in modern synthesis. The application of Bu3SnH- mediated cyclisations have proved especially useful. The critical review illustrates the mechanistic considerations required for planning synthetic applications and a wide range of synthetic protocols and natural product syntheses are shown. The latest evidence for the mechanisms involved in aromatic homolytic substitution are presented. (152 references).
| Original language | English |
|---|---|
| Pages (from-to) | 1803-1822 |
| Number of pages | 20 |
| Journal | Chemical Society Reviews |
| Volume | 36 |
| Issue number | 11 |
| Early online date | 5 Jul 2007 |
| DOIs | |
| Publication status | Published - Nov 2007 |
Keywords
- radical IPSO-substituion
- 6-membered heterocyclic rings
- antitumor polycyclic acridines
- electron-transfer processes
- tert-butylmercury halides
- solid-phase synthesis
- aryl radicals
- cyclization reactions
- tributyltin hydride
- imidoyl radicals