T*1e and T*2e maps derived in vivo from the rat using longitudinally detected electron spin resonance phase imaging: application to abdominal oxygen mapping

I. Panagiotelis, I. Nicholson, James McDonald Strachan Hutchison, M. A. Foster

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    A novel imaging modality is introduced which uses radiofrequency longitudinally detected electron spin resonance (RF-LODESR). It is capable of providing qualitative and semi-quantitative information on a variety of parameters reflecting physiological function, the most significant being tissue oxygenation. Effective spin-lattice (T-1e*) and spin-spin (T-2e*) electronic relaxation time maps of the abdomen of living 200-g rats were generated after intravenous administration of a triarylmethyl free radical (TAM). These maps were used to evaluate oxygen distribution. Differences between the liver, kidneys, and bladder were noted. Conclusions were made regarding the distribution, perfusion, and excretion rate of the contrast medium. Ligature-induced anoxia in the kidney was also visualized. LODESR involves transverse ESR irradiation with a modulated excitation, and observing oscillations in the spin magnetization parallel to the main magnetic field. The T-1e* and T-2e* maps were calculated from a set of LODESR signal phase images collected at different detection frequencies. Each phase image also provides qualitative information on tissue oxygen levels without any further processing. This method presents an alternative to the conventional transverse ESR linewidth-based oximetry methods, particularly for animal whole-body imaging applications. (C) 2001 Wiley-Liss, Inc.

    Original languageEnglish
    Pages (from-to)1223-1232
    Number of pages9
    JournalMagnetic Resonance in Medicine
    Volume46
    Issue number6
    DOIs
    Publication statusPublished - 2001

    Keywords

    • LODESR
    • ESR
    • in vivo EPR
    • oxygen imaging
    • electron relaxation times
    • PARAMAGNETIC-RESONANCE
    • EPR OXIMETRY
    • NITROXIDES
    • TISSUES
    • MICE
    • MHZ

    Cite this

    T*1e and T*2e maps derived in vivo from the rat using longitudinally detected electron spin resonance phase imaging: application to abdominal oxygen mapping. / Panagiotelis, I.; Nicholson, I.; Hutchison, James McDonald Strachan; Foster, M. A.

    In: Magnetic Resonance in Medicine, Vol. 46, No. 6, 2001, p. 1223-1232.

    Research output: Contribution to journalArticle

    Panagiotelis, I. ; Nicholson, I. ; Hutchison, James McDonald Strachan ; Foster, M. A. / T*1e and T*2e maps derived in vivo from the rat using longitudinally detected electron spin resonance phase imaging: application to abdominal oxygen mapping. In: Magnetic Resonance in Medicine. 2001 ; Vol. 46, No. 6. pp. 1223-1232.
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    abstract = "A novel imaging modality is introduced which uses radiofrequency longitudinally detected electron spin resonance (RF-LODESR). It is capable of providing qualitative and semi-quantitative information on a variety of parameters reflecting physiological function, the most significant being tissue oxygenation. Effective spin-lattice (T-1e*) and spin-spin (T-2e*) electronic relaxation time maps of the abdomen of living 200-g rats were generated after intravenous administration of a triarylmethyl free radical (TAM). These maps were used to evaluate oxygen distribution. Differences between the liver, kidneys, and bladder were noted. Conclusions were made regarding the distribution, perfusion, and excretion rate of the contrast medium. Ligature-induced anoxia in the kidney was also visualized. LODESR involves transverse ESR irradiation with a modulated excitation, and observing oscillations in the spin magnetization parallel to the main magnetic field. The T-1e* and T-2e* maps were calculated from a set of LODESR signal phase images collected at different detection frequencies. Each phase image also provides qualitative information on tissue oxygen levels without any further processing. This method presents an alternative to the conventional transverse ESR linewidth-based oximetry methods, particularly for animal whole-body imaging applications. (C) 2001 Wiley-Liss, Inc.",
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