TauRx global phase 3 trial in Alzheimer's disease with tau aggregation inhibitor LMTX

Research output: Contribution to journalAbstract

Abstract

There have been 19 phase2/3 clinical trial failures in 15,000 AD subjects to date, all aiming to reduce amyloid pathology. The tau theory has offered an entirely viable alternative conceptual framework, largely ignored for the last 20 years. The filaments of the Alzheimer neurofibrillary tangle are made of a truncated fragment from the repeat domain of tau. This truncated fragment can catalyse the conversion of normal soluble tau into aggregated oligomeric and fibrillary forms which, in turn, can infect neighbouring neurons.
Original languageEnglish
Pages (from-to)S26
Number of pages1
JournalNeurobiology of Aging
Volume35
Issue numberSuppl. 1
Early online date14 Mar 2014
DOIs
Publication statusPublished - Mar 2014
Event13th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy - Geneva, Switzerland
Duration: 26 Mar 201429 Mar 2014

Keywords

  • tau
  • methylthioninium
  • Alzheimer's disease

Cite this

@article{396f915e14d64f788c5db0d249984dc8,
title = "TauRx global phase 3 trial in Alzheimer's disease with tau aggregation inhibitor LMTX",
abstract = "There have been 19 phase2/3 clinical trial failures in 15,000 AD subjects to date, all aiming to reduce amyloid pathology. The tau theory has offered an entirely viable alternative conceptual framework, largely ignored for the last 20 years. The filaments of the Alzheimer neurofibrillary tangle are made of a truncated fragment from the repeat domain of tau. This truncated fragment can catalyse the conversion of normal soluble tau into aggregated oligomeric and fibrillary forms which, in turn, can infect neighbouring neurons.",
keywords = "tau, methylthioninium, Alzheimer's disease",
author = "Wischik, {Claude M.} and Harrington, {C. R.} and Storey, {J. M. D.}",
year = "2014",
month = "3",
doi = "10.1016/j.neurobiolaging.2014.01.128",
language = "English",
volume = "35",
pages = "S26",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "ACADEMIC PRESS INC ELSEVIER SCIENCE",
number = "Suppl. 1",

}

TY - JOUR

T1 - TauRx global phase 3 trial in Alzheimer's disease with tau aggregation inhibitor LMTX

AU - Wischik, Claude M.

AU - Harrington, C. R.

AU - Storey, J. M. D.

PY - 2014/3

Y1 - 2014/3

N2 - There have been 19 phase2/3 clinical trial failures in 15,000 AD subjects to date, all aiming to reduce amyloid pathology. The tau theory has offered an entirely viable alternative conceptual framework, largely ignored for the last 20 years. The filaments of the Alzheimer neurofibrillary tangle are made of a truncated fragment from the repeat domain of tau. This truncated fragment can catalyse the conversion of normal soluble tau into aggregated oligomeric and fibrillary forms which, in turn, can infect neighbouring neurons.

AB - There have been 19 phase2/3 clinical trial failures in 15,000 AD subjects to date, all aiming to reduce amyloid pathology. The tau theory has offered an entirely viable alternative conceptual framework, largely ignored for the last 20 years. The filaments of the Alzheimer neurofibrillary tangle are made of a truncated fragment from the repeat domain of tau. This truncated fragment can catalyse the conversion of normal soluble tau into aggregated oligomeric and fibrillary forms which, in turn, can infect neighbouring neurons.

KW - tau

KW - methylthioninium

KW - Alzheimer's disease

U2 - 10.1016/j.neurobiolaging.2014.01.128

DO - 10.1016/j.neurobiolaging.2014.01.128

M3 - Abstract

VL - 35

SP - S26

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - Suppl. 1

ER -