The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills

S. Harris, Helen Catherine Fox, A. F. Wright, C. Hayward, J. M. Starr, Lawrence Jeffrey Whalley, I. J. Deary

    Research output: Contribution to journalArticle

    123 Citations (Scopus)

    Abstract

    A polymorphism (Val66Met) in the gene encoding brain-derived neurotrophic factor (BDNF) has previously been associated with impaired hippocampal function and scores on the Logical Memory subtest of the Wechsler Memory Scale-Revised (WMS-R). Despite its widespread expression in the brain, there have been few studies examining the role of BDNF on cognitive domains, other than memory. We examined the association between BDNF Val66Met genotype and non-verbal reasoning, as measured by Raven's standard progressive matrices (Raven), in two cohorts of relatively healthy older people, one aged 79 (LBC1921) and the other aged 64 (ABC1936) years. LBC1921 and ABC1936 subjects had reasoning measured at age 11 years, using the Moray House Test (MHT), in the Scottish Mental Surveys of 1932 and 1947, respectively. BDNF genotype was significantly associated with later life Raven scores, controlling for sex, age 11 MHT score and cohort (P = 0.001). MHT, Verbal Fluency and Logical Memory scores were available, in later life, for LBC1921 only. BDNF genotype was significantly associated with age 79 MHT score, controlling for sex and age 11 MHT score (P = 0.016). In both significant associations, Met homozygotes scored significantly higher than heterozygotes and Val homozygotes. This study indicates that BDNF genotype contributes to age-related changes in reasoning skills, which are closely related to general intelligence.

    Original languageEnglish
    Pages (from-to)505-513
    Number of pages8
    JournalMolecular Psychiatry
    Volume11
    Issue number6
    DOIs
    Publication statusPublished - May 2006

    Keywords

    • ageing
    • behavioural genetics
    • cognition
    • intelligence
    • neurotrophic factors
    • FACTOR VAL66MET POLYMORPHISM
    • ACTIVITY-DEPENDENT SECRETION
    • SPORADIC ALZHEIMERS-DISEASE
    • SCOTTISH MENTAL SURVEY
    • BDNF MESSENGER-RNA
    • GENE POLYMORPHISMS
    • COGNITIVE-ABILITY
    • HIPPOCAMPAL-FORMATION
    • PARKINSONS-DISEASE
    • PERSONALITY-TRAIT

    Cite this

    Harris, S., Fox, H. C., Wright, A. F., Hayward, C., Starr, J. M., Whalley, L. J., & Deary, I. J. (2006). The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills. Molecular Psychiatry, 11(6), 505-513. https://doi.org/10.1038/SJ.MP.4001799

    The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills. / Harris, S.; Fox, Helen Catherine; Wright, A. F.; Hayward, C.; Starr, J. M.; Whalley, Lawrence Jeffrey; Deary, I. J.

    In: Molecular Psychiatry, Vol. 11, No. 6, 05.2006, p. 505-513.

    Research output: Contribution to journalArticle

    Harris, S, Fox, HC, Wright, AF, Hayward, C, Starr, JM, Whalley, LJ & Deary, IJ 2006, 'The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills', Molecular Psychiatry, vol. 11, no. 6, pp. 505-513. https://doi.org/10.1038/SJ.MP.4001799
    Harris, S. ; Fox, Helen Catherine ; Wright, A. F. ; Hayward, C. ; Starr, J. M. ; Whalley, Lawrence Jeffrey ; Deary, I. J. / The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills. In: Molecular Psychiatry. 2006 ; Vol. 11, No. 6. pp. 505-513.
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    AU - Harris, S.

    AU - Fox, Helen Catherine

    AU - Wright, A. F.

    AU - Hayward, C.

    AU - Starr, J. M.

    AU - Whalley, Lawrence Jeffrey

    AU - Deary, I. J.

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    AB - A polymorphism (Val66Met) in the gene encoding brain-derived neurotrophic factor (BDNF) has previously been associated with impaired hippocampal function and scores on the Logical Memory subtest of the Wechsler Memory Scale-Revised (WMS-R). Despite its widespread expression in the brain, there have been few studies examining the role of BDNF on cognitive domains, other than memory. We examined the association between BDNF Val66Met genotype and non-verbal reasoning, as measured by Raven's standard progressive matrices (Raven), in two cohorts of relatively healthy older people, one aged 79 (LBC1921) and the other aged 64 (ABC1936) years. LBC1921 and ABC1936 subjects had reasoning measured at age 11 years, using the Moray House Test (MHT), in the Scottish Mental Surveys of 1932 and 1947, respectively. BDNF genotype was significantly associated with later life Raven scores, controlling for sex, age 11 MHT score and cohort (P = 0.001). MHT, Verbal Fluency and Logical Memory scores were available, in later life, for LBC1921 only. BDNF genotype was significantly associated with age 79 MHT score, controlling for sex and age 11 MHT score (P = 0.016). In both significant associations, Met homozygotes scored significantly higher than heterozygotes and Val homozygotes. This study indicates that BDNF genotype contributes to age-related changes in reasoning skills, which are closely related to general intelligence.

    KW - ageing

    KW - behavioural genetics

    KW - cognition

    KW - intelligence

    KW - neurotrophic factors

    KW - FACTOR VAL66MET POLYMORPHISM

    KW - ACTIVITY-DEPENDENT SECRETION

    KW - SPORADIC ALZHEIMERS-DISEASE

    KW - SCOTTISH MENTAL SURVEY

    KW - BDNF MESSENGER-RNA

    KW - GENE POLYMORPHISMS

    KW - COGNITIVE-ABILITY

    KW - HIPPOCAMPAL-FORMATION

    KW - PARKINSONS-DISEASE

    KW - PERSONALITY-TRAIT

    U2 - 10.1038/SJ.MP.4001799

    DO - 10.1038/SJ.MP.4001799

    M3 - Article

    VL - 11

    SP - 505

    EP - 513

    JO - Molecular Psychiatry

    JF - Molecular Psychiatry

    SN - 1359-4184

    IS - 6

    ER -