The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies

W M Xu, L Z Liu, P Emson, C R Harrington, I G McKeith, R H Perry, C M Morris, I G Charles

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We report the analysis of the allele distribution of a (CCTTT)n pentanucleotide repeat within the promoter region of the NOS2A gene in DNA samples from patients with autopsy confirmed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) type. A significant difference was observed in the allelic distribution between the control group and the DLB group (chi(2) = 15.175, df = 5; p < 0.01), with an increased occurrence of the eight and nine repeat alleles, and a marked under representation of the 11 repeat allele. Genotype frequencies in the DLB group also differed significantly from controls (p<0.012). These results suggest that variations in the NOS2A gene may predispose to the development of DLB. NeuroReport 11:297-299 (C) 2000 Lippincott Williams & Wilkins.

Original languageEnglish
Pages (from-to)297-299
Number of pages3
JournalNeuroreport
Volume11
Publication statusPublished - 2000

Keywords

  • CCTTT repeat
  • DLB
  • NOS2A promoter polymorphism
  • NITRIC-OXIDE SYNTHASE
  • ALZHEIMERS-DISEASE
  • APOLIPOPROTEIN-E
  • SENILE DEMENTIA
  • BODY DEMENTIA

Cite this

Xu, W. M., Liu, L. Z., Emson, P., Harrington, C. R., McKeith, I. G., Perry, R. H., ... Charles, I. G. (2000). The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies. Neuroreport, 11, 297-299.

The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies. / Xu, W M ; Liu, L Z ; Emson, P ; Harrington, C R ; McKeith, I G ; Perry, R H ; Morris, C M ; Charles, I G .

In: Neuroreport, Vol. 11, 2000, p. 297-299.

Research output: Contribution to journalArticle

Xu, WM, Liu, LZ, Emson, P, Harrington, CR, McKeith, IG, Perry, RH, Morris, CM & Charles, IG 2000, 'The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies' Neuroreport, vol. 11, pp. 297-299.
Xu, W M ; Liu, L Z ; Emson, P ; Harrington, C R ; McKeith, I G ; Perry, R H ; Morris, C M ; Charles, I G . / The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies. In: Neuroreport. 2000 ; Vol. 11. pp. 297-299.
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AU - Xu, W M

AU - Liu, L Z

AU - Emson, P

AU - Harrington, C R

AU - McKeith, I G

AU - Perry, R H

AU - Morris, C M

AU - Charles, I G

PY - 2000

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N2 - We report the analysis of the allele distribution of a (CCTTT)n pentanucleotide repeat within the promoter region of the NOS2A gene in DNA samples from patients with autopsy confirmed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) type. A significant difference was observed in the allelic distribution between the control group and the DLB group (chi(2) = 15.175, df = 5; p < 0.01), with an increased occurrence of the eight and nine repeat alleles, and a marked under representation of the 11 repeat allele. Genotype frequencies in the DLB group also differed significantly from controls (p<0.012). These results suggest that variations in the NOS2A gene may predispose to the development of DLB. NeuroReport 11:297-299 (C) 2000 Lippincott Williams & Wilkins.

AB - We report the analysis of the allele distribution of a (CCTTT)n pentanucleotide repeat within the promoter region of the NOS2A gene in DNA samples from patients with autopsy confirmed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) type. A significant difference was observed in the allelic distribution between the control group and the DLB group (chi(2) = 15.175, df = 5; p < 0.01), with an increased occurrence of the eight and nine repeat alleles, and a marked under representation of the 11 repeat allele. Genotype frequencies in the DLB group also differed significantly from controls (p<0.012). These results suggest that variations in the NOS2A gene may predispose to the development of DLB. NeuroReport 11:297-299 (C) 2000 Lippincott Williams & Wilkins.

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KW - DLB

KW - NOS2A promoter polymorphism

KW - NITRIC-OXIDE SYNTHASE

KW - ALZHEIMERS-DISEASE

KW - APOLIPOPROTEIN-E

KW - SENILE DEMENTIA

KW - BODY DEMENTIA

M3 - Article

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JF - Neuroreport

SN - 0959-4965

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