The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies

W M  Xu; L Z  Liu; P  Emson; C R  Harrington; I G  McKeith; R H  Perry; C M  Morris; I G  Charles

The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies

W M Xu, L Z Liu, P Emson, C R Harrington, I G McKeith, R H Perry, C M Morris, I G Charles

Applied Health Sciences

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Abstract

We report the analysis of the allele distribution of a (CCTTT)n pentanucleotide repeat within the promoter region of the NOS2A gene in DNA samples from patients with autopsy confirmed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) type. A significant difference was observed in the allelic distribution between the control group and the DLB group (chi(2) = 15.175, df = 5; p < 0.01), with an increased occurrence of the eight and nine repeat alleles, and a marked under representation of the 11 repeat allele. Genotype frequencies in the DLB group also differed significantly from controls (p<0.012). These results suggest that variations in the NOS2A gene may predispose to the development of DLB. NeuroReport 11:297-299 (C) 2000 Lippincott Williams & Wilkins.

Original language	English
Pages (from-to)	297-299
Number of pages	3
Journal	Neuroreport
Volume	11
Publication status	Published - 2000

Keywords

CCTTT repeat
DLB
NOS2A promoter polymorphism
NITRIC-OXIDE SYNTHASE
ALZHEIMERS-DISEASE
APOLIPOPROTEIN-E
SENILE DEMENTIA
BODY DEMENTIA

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@article{7a42af383986424283b9efa0932eba6c,

title = "The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies",

abstract = "We report the analysis of the allele distribution of a (CCTTT)n pentanucleotide repeat within the promoter region of the NOS2A gene in DNA samples from patients with autopsy confirmed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) type. A significant difference was observed in the allelic distribution between the control group and the DLB group (chi(2) = 15.175, df = 5; p < 0.01), with an increased occurrence of the eight and nine repeat alleles, and a marked under representation of the 11 repeat allele. Genotype frequencies in the DLB group also differed significantly from controls (p<0.012). These results suggest that variations in the NOS2A gene may predispose to the development of DLB. NeuroReport 11:297-299 (C) 2000 Lippincott Williams & Wilkins.",

keywords = "CCTTT repeat, DLB, NOS2A promoter polymorphism, NITRIC-OXIDE SYNTHASE, ALZHEIMERS-DISEASE, APOLIPOPROTEIN-E, SENILE DEMENTIA, BODY DEMENTIA",

author = "Xu, {W M} and Liu, {L Z} and P Emson and Harrington, {C R} and McKeith, {I G} and Perry, {R H} and Morris, {C M} and Charles, {I G}",

year = "2000",

language = "English",

volume = "11",

pages = "297--299",

journal = "Neuroreport",

issn = "0959-4965",

publisher = "LWW",

}

TY - JOUR

T1 - The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies

AU - Xu, W M

AU - Liu, L Z

AU - Emson, P

AU - Harrington, C R

AU - McKeith, I G

AU - Perry, R H

AU - Morris, C M

AU - Charles, I G

PY - 2000

Y1 - 2000

N2 - We report the analysis of the allele distribution of a (CCTTT)n pentanucleotide repeat within the promoter region of the NOS2A gene in DNA samples from patients with autopsy confirmed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) type. A significant difference was observed in the allelic distribution between the control group and the DLB group (chi(2) = 15.175, df = 5; p < 0.01), with an increased occurrence of the eight and nine repeat alleles, and a marked under representation of the 11 repeat allele. Genotype frequencies in the DLB group also differed significantly from controls (p<0.012). These results suggest that variations in the NOS2A gene may predispose to the development of DLB. NeuroReport 11:297-299 (C) 2000 Lippincott Williams & Wilkins.

AB - We report the analysis of the allele distribution of a (CCTTT)n pentanucleotide repeat within the promoter region of the NOS2A gene in DNA samples from patients with autopsy confirmed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) type. A significant difference was observed in the allelic distribution between the control group and the DLB group (chi(2) = 15.175, df = 5; p < 0.01), with an increased occurrence of the eight and nine repeat alleles, and a marked under representation of the 11 repeat allele. Genotype frequencies in the DLB group also differed significantly from controls (p<0.012). These results suggest that variations in the NOS2A gene may predispose to the development of DLB. NeuroReport 11:297-299 (C) 2000 Lippincott Williams & Wilkins.

KW - CCTTT repeat

KW - DLB

KW - NOS2A promoter polymorphism

KW - NITRIC-OXIDE SYNTHASE

KW - ALZHEIMERS-DISEASE

KW - APOLIPOPROTEIN-E

KW - SENILE DEMENTIA

KW - BODY DEMENTIA

M3 - Article

SN - 0959-4965

VL - 11

SP - 297

EP - 299

JO - Neuroreport

JF - Neuroreport

ER -

The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies

Abstract

Keywords

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