The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies

W M Xu, L Z Liu, P Emson, C R Harrington, I G McKeith, R H Perry, C M Morris, I G Charles

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Abstract

We report the analysis of the allele distribution of a (CCTTT)n pentanucleotide repeat within the promoter region of the NOS2A gene in DNA samples from patients with autopsy confirmed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) type. A significant difference was observed in the allelic distribution between the control group and the DLB group (chi(2) = 15.175, df = 5; p < 0.01), with an increased occurrence of the eight and nine repeat alleles, and a marked under representation of the 11 repeat allele. Genotype frequencies in the DLB group also differed significantly from controls (p<0.012). These results suggest that variations in the NOS2A gene may predispose to the development of DLB. NeuroReport 11:297-299 (C) 2000 Lippincott Williams & Wilkins.

Original languageEnglish
Pages (from-to)297-299
Number of pages3
JournalNeuroreport
Volume11
Publication statusPublished - 2000

Keywords

  • CCTTT repeat
  • DLB
  • NOS2A promoter polymorphism
  • NITRIC-OXIDE SYNTHASE
  • ALZHEIMERS-DISEASE
  • APOLIPOPROTEIN-E
  • SENILE DEMENTIA
  • BODY DEMENTIA

Cite this

Xu, W. M., Liu, L. Z., Emson, P., Harrington, C. R., McKeith, I. G., Perry, R. H., Morris, C. M., & Charles, I. G. (2000). The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies. Neuroreport, 11, 297-299.