The cellular response of normal human colonocytes to folate deficiency in vitro: proteomic and functional analyses

Susan Joyce Duthie, Charles Bestwick, Y. Mavrommatis, M. P. Moyer, Lynn Peters Pirie

Research output: Contribution to journalArticle

Abstract

Low folate intake is associated with colon cancer. We combined a proteomics and biochemical approach to identify proteins and pathways affected by folate deficiency in human colonocytes. Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].

Original languageEnglish
Pages (from-to)46A-121A
Number of pages1
JournalProceedings of the Nutrition Society
Volume65
DOIs
Publication statusPublished - 2006

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