Low folate intake is associated with colon cancer. We combined a proteomics and biochemical approach to identify proteins and pathways affected by folate deficiency in human colonocytes. Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].
Duthie, S. J., Bestwick, C., Mavrommatis, Y., Moyer, M. P., & Pirie, L. P. (2006). The cellular response of normal human colonocytes to folate deficiency in vitro: proteomic and functional analyses. Proceedings of the Nutrition Society, 65, 46A-121A. https://doi.org/10.1017/S002966510600526X