TY - JOUR
T1 - The cellular response of normal human colonocytes to folate deficiency in vitro
T2 - proteomic and functional analyses
AU - Duthie, Susan Joyce
AU - Bestwick, Charles
AU - Mavrommatis, Y.
AU - Moyer, M. P.
AU - Pirie, Lynn Peters
PY - 2006
Y1 - 2006
N2 - Low folate intake is associated with colon cancer. We combined a proteomics and biochemical approach to identify proteins and pathways affected by folate deficiency in human colonocytes. Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].
AB - Low folate intake is associated with colon cancer. We combined a proteomics and biochemical approach to identify proteins and pathways affected by folate deficiency in human colonocytes. Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].
U2 - 10.1017/S002966510600526X
DO - 10.1017/S002966510600526X
M3 - Article
SN - 0029-6651
VL - 65
SP - 46A-121A
JO - Proceedings of the Nutrition Society
JF - Proceedings of the Nutrition Society
ER -
