The cellular response of normal human colonocytes to folate deficiency in vitro: proteomic and functional analyses

Susan Joyce Duthie, Charles Bestwick, Y. Mavrommatis, M. P. Moyer, Lynn Peters Pirie

Research output: Contribution to journalArticle

Abstract

Low folate intake is associated with colon cancer. We combined a proteomics and biochemical approach to identify proteins and pathways affected by folate deficiency in human colonocytes. Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].

Original languageEnglish
Pages (from-to)46A-121A
Number of pages1
JournalProceedings of the Nutrition Society
Volume65
DOIs
Publication statusPublished - 2006

Cite this

The cellular response of normal human colonocytes to folate deficiency in vitro : proteomic and functional analyses. / Duthie, Susan Joyce; Bestwick, Charles; Mavrommatis, Y.; Moyer, M. P.; Pirie, Lynn Peters.

In: Proceedings of the Nutrition Society, Vol. 65, 2006, p. 46A-121A.

Research output: Contribution to journalArticle

Duthie, Susan Joyce ; Bestwick, Charles ; Mavrommatis, Y. ; Moyer, M. P. ; Pirie, Lynn Peters. / The cellular response of normal human colonocytes to folate deficiency in vitro : proteomic and functional analyses. In: Proceedings of the Nutrition Society. 2006 ; Vol. 65. pp. 46A-121A.
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