The complete DNA sequence of yeast chromosome III

S. G. Oliver*, Q. J.M. Van Der Aart, M. L. Agostoni-Carbone, M. Aigle, L. Alberghina, D. Alexandraki, G. Antoine, R. Anwar, J. P.G. Ballesta, P. Benit, G. Berben, E. Bergantino, N. Biteau, P. A. Bolle, M. Bolotin-Fukuhara, A. Brown, A. J.P. Brown, J. M. Buhler, C. Carcano, G. CarignaniH. Cederberg, R. Chanet, R. Contreras, M. Crouzet, B. Daignan-Fornier, E. Defoor, M. Delgado, J. Demolder, C. Doira, E. Dubois, B. Dujon, A. Dusterhoft, D. Erdmann, M. Esteban, F. Fabre, C. Fairhead, G. Faye, H. Feldmann, W. Fiers, M. C. Francingues-Gaillard, L. Franco, L. Frontali, H. Fukuhara, L. J. Fuller, P. Galland, M. E. Gent, D. Gigot, V. Gilliquet, N. Glansdorff, A. Goffeau, M. Grenson, P. Grisanti, L. A. Grivell, M. De Haan, M. Haasemann, D. Hatat, J. Hoenicka, J. Hegemann, C. J. Herbert, F. Hilger, S. Hohmann, C. P. Hollenberg, K. Huse, F. Iborra, K. J. Indje, K. Isono, C. Jacq, M. Jacquet, C. M. James, J. C. Jauniaux, Y. Jia, A. Jimenez, A. Kelly, U. Kleinhans, P. Kreisl, G. Lanfranchi, C. Lewis, C. G. Van Der Linden, G. Lucchini, K. Lutzenkirchen, M. J. Maat, L. Mallet, G. Mannhaupet, E. Martegani, A. Mathieu, C. T.C. Maurer, D. McConnell, R. A. McKee, F. Messenguy, H. W. Mewes, F. Molemans, M. A. Montague, M. Muzi Falconi, L. Navas, C. S. Newlon, D. Noone, C. Pallier, L. Panzeri, B. M. Pearson, J. Perea, P. Philippsen, A. Pierard, R. J. Planta, P. Plevani, B. Poetsch, F. Pohl, B. Purnelle, M. Ramezani Rad, S. W. Rasmussen, A. Raynal, M. Remacha, P. Richterich, A. B. Roberts, F. Rodriguez, E. Sanz, I. Schaaff-Gerstenschlager, B. Scherens, B. Schweitzer, Y. Shu, J. Skala, P. P. Slonimski, F. Sor, C. Soustelle, R. Spiegelberg, L. I. Stateva, H. Y. Steensma, S. Steiner, A. Thierry, G. Thireos, M. Tzermia, L. A. Urrestarazu, G. Valle, I. Vetter, J. C. Van Vliet-Reedijk, M. Voet, G. Volckaert, P. Vreken, H. Wang, J. R. Warmington, D. Von Wettstein, B. L. Wicksteed, C. Wilson, H. Wurst, G. Xu, A. Yoshikawa, F. K. Zimmermann, J. G. Sgouros

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

The entire DNA sequence of chromosome III of the yeast Saccharomyces cerevisiae has been determined. This is the first complete sequence analysis of an entire chromosome from any organism. The 315-kilobase sequence reveals 182 open reading frames for proteins longer than 100 amino acids, of which 37 correspond to known genes and 29 more show some similarity to sequences in databases. Of 55 new open reading frames analysed by gene disruption, three are essential genes; of 42 non-essential genes that were tested, 14 show some discernible effect on phenotype and the remaining 28 have no overt function.

Original languageEnglish
Pages (from-to)38-46
Number of pages9
JournalNature
Volume357
Issue number6373
DOIs
Publication statusPublished - 1 Jan 1992

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    Oliver, S. G., Van Der Aart, Q. J. M., Agostoni-Carbone, M. L., Aigle, M., Alberghina, L., Alexandraki, D., Antoine, G., Anwar, R., Ballesta, J. P. G., Benit, P., Berben, G., Bergantino, E., Biteau, N., Bolle, P. A., Bolotin-Fukuhara, M., Brown, A., Brown, A. J. P., Buhler, J. M., Carcano, C., ... Sgouros, J. G. (1992). The complete DNA sequence of yeast chromosome III. Nature, 357(6373), 38-46. https://doi.org/10.1038/357038a0