The effect of a six-month exercise program on very low density lipoprotein apolipoprotein B secretion in type 2 diabetes

S. Alam, M. Stolinski, C. Pentecost, Massoud Boroujerdi, R. H. Jones, P. H. Sonksen, A. M. Umpleby

    Research output: Contribution to journalArticle

    59 Citations (Scopus)

    Abstract

    The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. The effect of 6 months supervised exercise on very low-density lipoprotein (VLDL) apolipoprotein B metabolism was investigated in patients with type 2 diabetes. Moderately obese patients (n = 18) were randomized into supervised (n = 9) and unsupervised (n = 9) exercise groups. All patients were given a training session and a personal exercise program and asked to exercise four times per week at 70% maximal oxygen uptake for 6 months. Patients in the supervised group had a weekly session with an exercise trainer. VLDL apolipoprotein (apo) B metabolism was measured with an infusion of 1-C-13 leucine before and after 6 months of the exercise program.

    Supervised exercise for 6 months resulted in a significant within-group decrease in percent hemoglobin A1c (P < 0.001), body fat (P < 0.004), nonesterified fatty acid (P < 0.04), and triglycerides (P < 0.05) and an increase in insulin sensitivity (P < 0.01). There was a decrease in VLDL apoB pool size (160.8 +/- 42.6 to 84.9 +/- 23.2 mg, P < 0.01) and VLDL apoB secretion rate (11.3 +/- 2.6 to 5.5 +/- 2.0 mg/kg.d, P < 0.05) with no change in fractional catabolic rate. In a between-group comparison, the decrease in VLDL apoB secretion rate in the supervised group did not achieve significance. This study demonstrates that in type 2 diabetes, a supervised exercise program reduces VLDL apoB pool size, which may be due to a decrease in VLDL apoB secretion rate.

    Original languageEnglish
    Pages (from-to)688-694
    Number of pages6
    JournalJournal of Clinical Endocrinology and Metabolism
    Volume89
    Issue number2
    DOIs
    Publication statusPublished - 2004

    Keywords

    • free fatty-acids
    • coronary-artery-disease
    • viceral adipose-tissue
    • hepatic secretion
    • insulin-resistance
    • cardiovascular-disease
    • plasma-lipoproteins
    • risk-factors
    • triglyceride
    • B-100

    Cite this

    The effect of a six-month exercise program on very low density lipoprotein apolipoprotein B secretion in type 2 diabetes. / Alam, S.; Stolinski, M.; Pentecost, C.; Boroujerdi, Massoud; Jones, R. H.; Sonksen, P. H.; Umpleby, A. M.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 89, No. 2, 2004, p. 688-694.

    Research output: Contribution to journalArticle

    Alam, S. ; Stolinski, M. ; Pentecost, C. ; Boroujerdi, Massoud ; Jones, R. H. ; Sonksen, P. H. ; Umpleby, A. M. / The effect of a six-month exercise program on very low density lipoprotein apolipoprotein B secretion in type 2 diabetes. In: Journal of Clinical Endocrinology and Metabolism. 2004 ; Vol. 89, No. 2. pp. 688-694.
    @article{de1ca951a48f4c4b82da733f2b1b0835,
    title = "The effect of a six-month exercise program on very low density lipoprotein apolipoprotein B secretion in type 2 diabetes",
    abstract = "The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. The effect of 6 months supervised exercise on very low-density lipoprotein (VLDL) apolipoprotein B metabolism was investigated in patients with type 2 diabetes. Moderately obese patients (n = 18) were randomized into supervised (n = 9) and unsupervised (n = 9) exercise groups. All patients were given a training session and a personal exercise program and asked to exercise four times per week at 70{\%} maximal oxygen uptake for 6 months. Patients in the supervised group had a weekly session with an exercise trainer. VLDL apolipoprotein (apo) B metabolism was measured with an infusion of 1-C-13 leucine before and after 6 months of the exercise program.Supervised exercise for 6 months resulted in a significant within-group decrease in percent hemoglobin A1c (P < 0.001), body fat (P < 0.004), nonesterified fatty acid (P < 0.04), and triglycerides (P < 0.05) and an increase in insulin sensitivity (P < 0.01). There was a decrease in VLDL apoB pool size (160.8 +/- 42.6 to 84.9 +/- 23.2 mg, P < 0.01) and VLDL apoB secretion rate (11.3 +/- 2.6 to 5.5 +/- 2.0 mg/kg.d, P < 0.05) with no change in fractional catabolic rate. In a between-group comparison, the decrease in VLDL apoB secretion rate in the supervised group did not achieve significance. This study demonstrates that in type 2 diabetes, a supervised exercise program reduces VLDL apoB pool size, which may be due to a decrease in VLDL apoB secretion rate.",
    keywords = "free fatty-acids, coronary-artery-disease, viceral adipose-tissue, hepatic secretion, insulin-resistance, cardiovascular-disease, plasma-lipoproteins, risk-factors, triglyceride, B-100",
    author = "S. Alam and M. Stolinski and C. Pentecost and Massoud Boroujerdi and Jones, {R. H.} and Sonksen, {P. H.} and Umpleby, {A. M.}",
    year = "2004",
    doi = "10.1210/jc.2003-031036",
    language = "English",
    volume = "89",
    pages = "688--694",
    journal = "Journal of Clinical Endocrinology and Metabolism",
    issn = "0021-972X",
    publisher = "The Endocrine Society",
    number = "2",

    }

    TY - JOUR

    T1 - The effect of a six-month exercise program on very low density lipoprotein apolipoprotein B secretion in type 2 diabetes

    AU - Alam, S.

    AU - Stolinski, M.

    AU - Pentecost, C.

    AU - Boroujerdi, Massoud

    AU - Jones, R. H.

    AU - Sonksen, P. H.

    AU - Umpleby, A. M.

    PY - 2004

    Y1 - 2004

    N2 - The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. The effect of 6 months supervised exercise on very low-density lipoprotein (VLDL) apolipoprotein B metabolism was investigated in patients with type 2 diabetes. Moderately obese patients (n = 18) were randomized into supervised (n = 9) and unsupervised (n = 9) exercise groups. All patients were given a training session and a personal exercise program and asked to exercise four times per week at 70% maximal oxygen uptake for 6 months. Patients in the supervised group had a weekly session with an exercise trainer. VLDL apolipoprotein (apo) B metabolism was measured with an infusion of 1-C-13 leucine before and after 6 months of the exercise program.Supervised exercise for 6 months resulted in a significant within-group decrease in percent hemoglobin A1c (P < 0.001), body fat (P < 0.004), nonesterified fatty acid (P < 0.04), and triglycerides (P < 0.05) and an increase in insulin sensitivity (P < 0.01). There was a decrease in VLDL apoB pool size (160.8 +/- 42.6 to 84.9 +/- 23.2 mg, P < 0.01) and VLDL apoB secretion rate (11.3 +/- 2.6 to 5.5 +/- 2.0 mg/kg.d, P < 0.05) with no change in fractional catabolic rate. In a between-group comparison, the decrease in VLDL apoB secretion rate in the supervised group did not achieve significance. This study demonstrates that in type 2 diabetes, a supervised exercise program reduces VLDL apoB pool size, which may be due to a decrease in VLDL apoB secretion rate.

    AB - The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. The effect of 6 months supervised exercise on very low-density lipoprotein (VLDL) apolipoprotein B metabolism was investigated in patients with type 2 diabetes. Moderately obese patients (n = 18) were randomized into supervised (n = 9) and unsupervised (n = 9) exercise groups. All patients were given a training session and a personal exercise program and asked to exercise four times per week at 70% maximal oxygen uptake for 6 months. Patients in the supervised group had a weekly session with an exercise trainer. VLDL apolipoprotein (apo) B metabolism was measured with an infusion of 1-C-13 leucine before and after 6 months of the exercise program.Supervised exercise for 6 months resulted in a significant within-group decrease in percent hemoglobin A1c (P < 0.001), body fat (P < 0.004), nonesterified fatty acid (P < 0.04), and triglycerides (P < 0.05) and an increase in insulin sensitivity (P < 0.01). There was a decrease in VLDL apoB pool size (160.8 +/- 42.6 to 84.9 +/- 23.2 mg, P < 0.01) and VLDL apoB secretion rate (11.3 +/- 2.6 to 5.5 +/- 2.0 mg/kg.d, P < 0.05) with no change in fractional catabolic rate. In a between-group comparison, the decrease in VLDL apoB secretion rate in the supervised group did not achieve significance. This study demonstrates that in type 2 diabetes, a supervised exercise program reduces VLDL apoB pool size, which may be due to a decrease in VLDL apoB secretion rate.

    KW - free fatty-acids

    KW - coronary-artery-disease

    KW - viceral adipose-tissue

    KW - hepatic secretion

    KW - insulin-resistance

    KW - cardiovascular-disease

    KW - plasma-lipoproteins

    KW - risk-factors

    KW - triglyceride

    KW - B-100

    U2 - 10.1210/jc.2003-031036

    DO - 10.1210/jc.2003-031036

    M3 - Article

    VL - 89

    SP - 688

    EP - 694

    JO - Journal of Clinical Endocrinology and Metabolism

    JF - Journal of Clinical Endocrinology and Metabolism

    SN - 0021-972X

    IS - 2

    ER -