The effect of a six-month exercise program on very low density lipoprotein apolipoprotein B secretion in type 2 diabetes

S. Alam, M. Stolinski, C. Pentecost, Massoud Boroujerdi, R. H. Jones, P. H. Sonksen, A. M. Umpleby

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    The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. The effect of 6 months supervised exercise on very low-density lipoprotein (VLDL) apolipoprotein B metabolism was investigated in patients with type 2 diabetes. Moderately obese patients (n = 18) were randomized into supervised (n = 9) and unsupervised (n = 9) exercise groups. All patients were given a training session and a personal exercise program and asked to exercise four times per week at 70% maximal oxygen uptake for 6 months. Patients in the supervised group had a weekly session with an exercise trainer. VLDL apolipoprotein (apo) B metabolism was measured with an infusion of 1-C-13 leucine before and after 6 months of the exercise program.

    Supervised exercise for 6 months resulted in a significant within-group decrease in percent hemoglobin A1c (P < 0.001), body fat (P < 0.004), nonesterified fatty acid (P < 0.04), and triglycerides (P < 0.05) and an increase in insulin sensitivity (P < 0.01). There was a decrease in VLDL apoB pool size (160.8 +/- 42.6 to 84.9 +/- 23.2 mg, P < 0.01) and VLDL apoB secretion rate (11.3 +/- 2.6 to 5.5 +/- 2.0 mg/kg.d, P < 0.05) with no change in fractional catabolic rate. In a between-group comparison, the decrease in VLDL apoB secretion rate in the supervised group did not achieve significance. This study demonstrates that in type 2 diabetes, a supervised exercise program reduces VLDL apoB pool size, which may be due to a decrease in VLDL apoB secretion rate.

    Original languageEnglish
    Pages (from-to)688-694
    Number of pages6
    JournalJournal of Clinical Endocrinology and Metabolism
    Issue number2
    Publication statusPublished - 2004


    • free fatty-acids
    • coronary-artery-disease
    • viceral adipose-tissue
    • hepatic secretion
    • insulin-resistance
    • cardiovascular-disease
    • plasma-lipoproteins
    • risk-factors
    • triglyceride
    • B-100


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