The Effect of Clenbuterol Administration Inutero and Throughout Lactation on Prenatal and Postnatal Muscle Development in the Rat

C A Maltin, Margaret Inkster Delday, Susan Hay

Research output: Contribution to journalArticle

Abstract

The beta-adrenergic agonist, clenbuterol was fed to pregnant rats during gestation and throughout lactation. Changes in muscle morphology and composition were studied in foetal and weanling rats. Drug treatment did not affect mean foetal number, but mean foetal body weight was significantly reduced. Heart weights were increased and both muscle weight and secondary to primary fibre ratios were decreased in foetuses exposed to clenbuterol in utero. In animals exposed to clenbuterol throughout gestation and lactation, muscle weights, and protein, RNA and DNA content and total fibre numbers were reduced. In addition a drug induced anabolism was observed in the muscles of the dams. The data are discussed in terms of a direct drug effect on immature and differentiated muscle together with a possible indirect action through the repartitioning action of clenbuterol.

Original languageEnglish
Pages (from-to)143-150
Number of pages8
JournalGrowth, Development, and Aging: GDA
Volume54
Issue number4
Publication statusPublished - 1990

Keywords

  • MUSCLE
  • DEVELOPMENT
  • GROWTH
  • CLENBUTEROL
  • BETA-AGONIST
  • BETA-AGONIST CLENBUTEROL
  • SKELETAL-MUSCLE
  • CARCASS COMPOSITION
  • ENERGY-METABOLISM
  • PROTEIN
  • DIFFERENTIATION
  • FIBERS
  • UNDERNUTRITION
  • STIMULATION
  • muscle
  • development
  • growth
  • clenbuterol
  • beta-agonist

Cite this

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title = "The Effect of Clenbuterol Administration Inutero and Throughout Lactation on Prenatal and Postnatal Muscle Development in the Rat",
abstract = "The beta-adrenergic agonist, clenbuterol was fed to pregnant rats during gestation and throughout lactation. Changes in muscle morphology and composition were studied in foetal and weanling rats. Drug treatment did not affect mean foetal number, but mean foetal body weight was significantly reduced. Heart weights were increased and both muscle weight and secondary to primary fibre ratios were decreased in foetuses exposed to clenbuterol in utero. In animals exposed to clenbuterol throughout gestation and lactation, muscle weights, and protein, RNA and DNA content and total fibre numbers were reduced. In addition a drug induced anabolism was observed in the muscles of the dams. The data are discussed in terms of a direct drug effect on immature and differentiated muscle together with a possible indirect action through the repartitioning action of clenbuterol.",
keywords = "MUSCLE, DEVELOPMENT, GROWTH, CLENBUTEROL, BETA-AGONIST, BETA-AGONIST CLENBUTEROL, SKELETAL-MUSCLE, CARCASS COMPOSITION, ENERGY-METABOLISM, PROTEIN, DIFFERENTIATION, FIBERS, UNDERNUTRITION, STIMULATION, muscle , development , growth, clenbuterol, beta-agonist",
author = "Maltin, {C A} and Delday, {Margaret Inkster} and Susan Hay",
year = "1990",
language = "English",
volume = "54",
pages = "143--150",
journal = "Growth, Development, and Aging: GDA",
issn = "0017-4793",
publisher = "Growth Publishing Co. Inc.",
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TY - JOUR

T1 - The Effect of Clenbuterol Administration Inutero and Throughout Lactation on Prenatal and Postnatal Muscle Development in the Rat

AU - Maltin, C A

AU - Delday, Margaret Inkster

AU - Hay, Susan

PY - 1990

Y1 - 1990

N2 - The beta-adrenergic agonist, clenbuterol was fed to pregnant rats during gestation and throughout lactation. Changes in muscle morphology and composition were studied in foetal and weanling rats. Drug treatment did not affect mean foetal number, but mean foetal body weight was significantly reduced. Heart weights were increased and both muscle weight and secondary to primary fibre ratios were decreased in foetuses exposed to clenbuterol in utero. In animals exposed to clenbuterol throughout gestation and lactation, muscle weights, and protein, RNA and DNA content and total fibre numbers were reduced. In addition a drug induced anabolism was observed in the muscles of the dams. The data are discussed in terms of a direct drug effect on immature and differentiated muscle together with a possible indirect action through the repartitioning action of clenbuterol.

AB - The beta-adrenergic agonist, clenbuterol was fed to pregnant rats during gestation and throughout lactation. Changes in muscle morphology and composition were studied in foetal and weanling rats. Drug treatment did not affect mean foetal number, but mean foetal body weight was significantly reduced. Heart weights were increased and both muscle weight and secondary to primary fibre ratios were decreased in foetuses exposed to clenbuterol in utero. In animals exposed to clenbuterol throughout gestation and lactation, muscle weights, and protein, RNA and DNA content and total fibre numbers were reduced. In addition a drug induced anabolism was observed in the muscles of the dams. The data are discussed in terms of a direct drug effect on immature and differentiated muscle together with a possible indirect action through the repartitioning action of clenbuterol.

KW - MUSCLE

KW - DEVELOPMENT

KW - GROWTH

KW - CLENBUTEROL

KW - BETA-AGONIST

KW - BETA-AGONIST CLENBUTEROL

KW - SKELETAL-MUSCLE

KW - CARCASS COMPOSITION

KW - ENERGY-METABOLISM

KW - PROTEIN

KW - DIFFERENTIATION

KW - FIBERS

KW - UNDERNUTRITION

KW - STIMULATION

KW - muscle

KW - development

KW - growth

KW - clenbuterol

KW - beta-agonist

M3 - Article

VL - 54

SP - 143

EP - 150

JO - Growth, Development, and Aging: GDA

JF - Growth, Development, and Aging: GDA

SN - 0017-4793

IS - 4

ER -