The Effect of Krill Oil Supplementation on Exercise Performance and Markers of Immune Function

Mariasole Da Boit, Ina Mastalurova, Goda Brazaite, Niall McGovern, Keith Thompson, Stuart Robert Gray

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Krill oil is a rich source of the long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which may alter immune function after exercise. The aim of the study was to determine the effects of krill oil supplementation on post exercise immune function and performance.

METHODS: Nineteen males and 18 females (age: 25.8 ± 5.3 years; mean ± S.D.) were randomly assigned to 2 g/day of krill oil (n = 18) or placebo (n = 19) supplementation for 6 weeks. A maximal incremental exercise test and cycling time trial (time to complete set amount of work) were performed pre-supplementation with the time trial repeated post-supplementation. Blood samples collected pre- and post- supplementation at rest, and immediately, 1 and 3h post-exercise. Plasma IL-6 and thiobarbituric acid reactive substances (TBARS) concentrations and, erythrocyte fatty acid composition were measured. Natural killer (NK) cell cytotoxic activity and peripheral blood mononuclear cell (PBMC) IL-2, IL-4, IL-10, IL-17 and IFNγ production were also measured.

RESULTS: No effects of gender were noted for any variable. PBMC IL-2 and NK cell cytotoxic activity were greater (P < 0.05) 3h post exercise in the krill oil compared to the control group. Plasma IL-6 and TBARS, PBMC IL-4, IL-10, IL-17 and IFNγ production, along with performance and physiological measures during exercise, were not different between groups.

CONCLUSION: Six weeks of krill oil supplementation can increase PBMC IL-2 production and NK cell cytotoxic activity 3h post-exercise in both healthy young males and females. Krill oil does not modify exercise performance.

Original languageEnglish
Article numbere0139174
Number of pages14
JournalPloS ONE
Volume10
Issue number9
Early online date25 Sep 2015
DOIs
Publication statusPublished - 25 Sep 2015

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Euphausiacea
krill
Oils
exercise
Biomarkers
Blood
oils
mononuclear leukocytes
Blood Cells
Natural Killer Cells
natural killer cells
Interleukin-2
interleukin-2
Thiobarbituric Acid Reactive Substances
Interleukin-17
Interleukin-4
Interleukin-10
interleukin-4
interleukin-10
Interleukin-6

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Da Boit, M., Mastalurova, I., Brazaite, G., McGovern, N., Thompson, K., & Gray, S. R. (2015). The Effect of Krill Oil Supplementation on Exercise Performance and Markers of Immune Function. PloS ONE, 10(9), [e0139174]. https://doi.org/10.1371/journal.pone.0139174

The Effect of Krill Oil Supplementation on Exercise Performance and Markers of Immune Function. / Da Boit, Mariasole; Mastalurova, Ina; Brazaite, Goda; McGovern, Niall; Thompson, Keith; Gray, Stuart Robert.

In: PloS ONE, Vol. 10, No. 9, e0139174, 25.09.2015.

Research output: Contribution to journalArticle

Da Boit, M, Mastalurova, I, Brazaite, G, McGovern, N, Thompson, K & Gray, SR 2015, 'The Effect of Krill Oil Supplementation on Exercise Performance and Markers of Immune Function', PloS ONE, vol. 10, no. 9, e0139174. https://doi.org/10.1371/journal.pone.0139174
Da Boit M, Mastalurova I, Brazaite G, McGovern N, Thompson K, Gray SR. The Effect of Krill Oil Supplementation on Exercise Performance and Markers of Immune Function. PloS ONE. 2015 Sep 25;10(9). e0139174. https://doi.org/10.1371/journal.pone.0139174
Da Boit, Mariasole ; Mastalurova, Ina ; Brazaite, Goda ; McGovern, Niall ; Thompson, Keith ; Gray, Stuart Robert. / The Effect of Krill Oil Supplementation on Exercise Performance and Markers of Immune Function. In: PloS ONE. 2015 ; Vol. 10, No. 9.
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abstract = "BACKGROUND: Krill oil is a rich source of the long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which may alter immune function after exercise. The aim of the study was to determine the effects of krill oil supplementation on post exercise immune function and performance.METHODS: Nineteen males and 18 females (age: 25.8 ± 5.3 years; mean ± S.D.) were randomly assigned to 2 g/day of krill oil (n = 18) or placebo (n = 19) supplementation for 6 weeks. A maximal incremental exercise test and cycling time trial (time to complete set amount of work) were performed pre-supplementation with the time trial repeated post-supplementation. Blood samples collected pre- and post- supplementation at rest, and immediately, 1 and 3h post-exercise. Plasma IL-6 and thiobarbituric acid reactive substances (TBARS) concentrations and, erythrocyte fatty acid composition were measured. Natural killer (NK) cell cytotoxic activity and peripheral blood mononuclear cell (PBMC) IL-2, IL-4, IL-10, IL-17 and IFNγ production were also measured.RESULTS: No effects of gender were noted for any variable. PBMC IL-2 and NK cell cytotoxic activity were greater (P < 0.05) 3h post exercise in the krill oil compared to the control group. Plasma IL-6 and TBARS, PBMC IL-4, IL-10, IL-17 and IFNγ production, along with performance and physiological measures during exercise, were not different between groups.CONCLUSION: Six weeks of krill oil supplementation can increase PBMC IL-2 production and NK cell cytotoxic activity 3h post-exercise in both healthy young males and females. Krill oil does not modify exercise performance.",
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AU - Brazaite, Goda

AU - McGovern, Niall

AU - Thompson, Keith

AU - Gray, Stuart Robert

N1 - Date of Acceptance: 08/09/2015 Acknowledgments We thank the technical support of the Institute of Medical Sciences Musculoskeletal Programme and the Iain Fraser Cytometry Centre.

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N2 - BACKGROUND: Krill oil is a rich source of the long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which may alter immune function after exercise. The aim of the study was to determine the effects of krill oil supplementation on post exercise immune function and performance.METHODS: Nineteen males and 18 females (age: 25.8 ± 5.3 years; mean ± S.D.) were randomly assigned to 2 g/day of krill oil (n = 18) or placebo (n = 19) supplementation for 6 weeks. A maximal incremental exercise test and cycling time trial (time to complete set amount of work) were performed pre-supplementation with the time trial repeated post-supplementation. Blood samples collected pre- and post- supplementation at rest, and immediately, 1 and 3h post-exercise. Plasma IL-6 and thiobarbituric acid reactive substances (TBARS) concentrations and, erythrocyte fatty acid composition were measured. Natural killer (NK) cell cytotoxic activity and peripheral blood mononuclear cell (PBMC) IL-2, IL-4, IL-10, IL-17 and IFNγ production were also measured.RESULTS: No effects of gender were noted for any variable. PBMC IL-2 and NK cell cytotoxic activity were greater (P < 0.05) 3h post exercise in the krill oil compared to the control group. Plasma IL-6 and TBARS, PBMC IL-4, IL-10, IL-17 and IFNγ production, along with performance and physiological measures during exercise, were not different between groups.CONCLUSION: Six weeks of krill oil supplementation can increase PBMC IL-2 production and NK cell cytotoxic activity 3h post-exercise in both healthy young males and females. Krill oil does not modify exercise performance.

AB - BACKGROUND: Krill oil is a rich source of the long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which may alter immune function after exercise. The aim of the study was to determine the effects of krill oil supplementation on post exercise immune function and performance.METHODS: Nineteen males and 18 females (age: 25.8 ± 5.3 years; mean ± S.D.) were randomly assigned to 2 g/day of krill oil (n = 18) or placebo (n = 19) supplementation for 6 weeks. A maximal incremental exercise test and cycling time trial (time to complete set amount of work) were performed pre-supplementation with the time trial repeated post-supplementation. Blood samples collected pre- and post- supplementation at rest, and immediately, 1 and 3h post-exercise. Plasma IL-6 and thiobarbituric acid reactive substances (TBARS) concentrations and, erythrocyte fatty acid composition were measured. Natural killer (NK) cell cytotoxic activity and peripheral blood mononuclear cell (PBMC) IL-2, IL-4, IL-10, IL-17 and IFNγ production were also measured.RESULTS: No effects of gender were noted for any variable. PBMC IL-2 and NK cell cytotoxic activity were greater (P < 0.05) 3h post exercise in the krill oil compared to the control group. Plasma IL-6 and TBARS, PBMC IL-4, IL-10, IL-17 and IFNγ production, along with performance and physiological measures during exercise, were not different between groups.CONCLUSION: Six weeks of krill oil supplementation can increase PBMC IL-2 production and NK cell cytotoxic activity 3h post-exercise in both healthy young males and females. Krill oil does not modify exercise performance.

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