The effect of oestrogen-ablation on the phospholipid metabolite content of primary and transplanted rat mammary tumours

Timothy Andrew Davies Smith; S Baluch; Jenny Titley; S A Eccles; Martin  Leach; Ralph McReady; J Griffiths

doi:10.1002/nbm.1940060307

The effect of oestrogen-ablation on the phospholipid metabolite content of primary and transplanted rat mammary tumours

Timothy Andrew Davies Smith, S Baluch, Jenny Titley, S A Eccles, Martin Leach, Ralph McReady, J Griffiths

Applied Medicine

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The concentration of phospholipid metabolites was determined in chemical extracts from two types of rat mammary tumours and compared with proliferation data (S-phase fraction). One of the tumours was an oestrogen-sensitive transplanted tumour. In this tumour the concentration of phosphocholine (PC) and glycerophosphorylcholine (GPC) correlated strongly with the S-phase fraction but not with the number of cells actively synthesizing DNA. Oestrogen ablation resulted in tumour regression. Regressing tumours contained less PC and more GPC than those actively growing. The other tumour was induced in rats by intravenous administration of N-methyl N-nitrosourea. Phosphoethanolamine (PE), PC and GPC levels were not associated with the S-phase fraction in this tumour. Oestrogen ablation resulted in tumour regression. There was no significant difference between the regressing and growing tumours in PE, PC or GPC content.

Original language	English
Pages (from-to)	209-214
Number of pages	6
Journal	NMR in Biomedicine
Volume	6
Issue number	3
DOIs	https://doi.org/10.1002/nbm.1940060307
Publication status	Published - 1993

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title = "The effect of oestrogen-ablation on the phospholipid metabolite content of primary and transplanted rat mammary tumours",

abstract = "The concentration of phospholipid metabolites was determined in chemical extracts from two types of rat mammary tumours and compared with proliferation data (S-phase fraction). One of the tumours was an oestrogen-sensitive transplanted tumour. In this tumour the concentration of phosphocholine (PC) and glycerophosphorylcholine (GPC) correlated strongly with the S-phase fraction but not with the number of cells actively synthesizing DNA. Oestrogen ablation resulted in tumour regression. Regressing tumours contained less PC and more GPC than those actively growing. The other tumour was induced in rats by intravenous administration of N-methyl N-nitrosourea. Phosphoethanolamine (PE), PC and GPC levels were not associated with the S-phase fraction in this tumour. Oestrogen ablation resulted in tumour regression. There was no significant difference between the regressing and growing tumours in PE, PC or GPC content.",

author = "Smith, {Timothy Andrew Davies} and S Baluch and Jenny Titley and Eccles, {S A} and Martin Leach and Ralph McReady and J Griffiths",

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T1 - The effect of oestrogen-ablation on the phospholipid metabolite content of primary and transplanted rat mammary tumours

AU - Smith, Timothy Andrew Davies

AU - Baluch, S

AU - Titley, Jenny

AU - Eccles, S A

AU - Leach, Martin

AU - McReady, Ralph

AU - Griffiths, J

PY - 1993

Y1 - 1993

N2 - The concentration of phospholipid metabolites was determined in chemical extracts from two types of rat mammary tumours and compared with proliferation data (S-phase fraction). One of the tumours was an oestrogen-sensitive transplanted tumour. In this tumour the concentration of phosphocholine (PC) and glycerophosphorylcholine (GPC) correlated strongly with the S-phase fraction but not with the number of cells actively synthesizing DNA. Oestrogen ablation resulted in tumour regression. Regressing tumours contained less PC and more GPC than those actively growing. The other tumour was induced in rats by intravenous administration of N-methyl N-nitrosourea. Phosphoethanolamine (PE), PC and GPC levels were not associated with the S-phase fraction in this tumour. Oestrogen ablation resulted in tumour regression. There was no significant difference between the regressing and growing tumours in PE, PC or GPC content.

AB - The concentration of phospholipid metabolites was determined in chemical extracts from two types of rat mammary tumours and compared with proliferation data (S-phase fraction). One of the tumours was an oestrogen-sensitive transplanted tumour. In this tumour the concentration of phosphocholine (PC) and glycerophosphorylcholine (GPC) correlated strongly with the S-phase fraction but not with the number of cells actively synthesizing DNA. Oestrogen ablation resulted in tumour regression. Regressing tumours contained less PC and more GPC than those actively growing. The other tumour was induced in rats by intravenous administration of N-methyl N-nitrosourea. Phosphoethanolamine (PE), PC and GPC levels were not associated with the S-phase fraction in this tumour. Oestrogen ablation resulted in tumour regression. There was no significant difference between the regressing and growing tumours in PE, PC or GPC content.

U2 - 10.1002/nbm.1940060307

DO - 10.1002/nbm.1940060307

M3 - Article

SN - 0952-3480

VL - 6

SP - 209

EP - 214

JO - NMR in Biomedicine

JF - NMR in Biomedicine

IS - 3

ER -

The effect of oestrogen-ablation on the phospholipid metabolite content of primary and transplanted rat mammary tumours

Abstract

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