The effect of oestrogen-ablation on the phospholipid metabolite content of primary and transplanted rat mammary tumours

Timothy Andrew Davies Smith, S Baluch, Jenny Titley, S A Eccles, Martin Leach, Ralph McReady, J Griffiths

Research output: Contribution to journalArticle

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Abstract

The concentration of phospholipid metabolites was determined in chemical extracts from two types of rat mammary tumours and compared with proliferation data (S-phase fraction). One of the tumours was an oestrogen-sensitive transplanted tumour. In this tumour the concentration of phosphocholine (PC) and glycerophosphorylcholine (GPC) correlated strongly with the S-phase fraction but not with the number of cells actively synthesizing DNA. Oestrogen ablation resulted in tumour regression. Regressing tumours contained less PC and more GPC than those actively growing. The other tumour was induced in rats by intravenous administration of N-methyl N-nitrosourea. Phosphoethanolamine (PE), PC and GPC levels were not associated with the S-phase fraction in this tumour. Oestrogen ablation resulted in tumour regression. There was no significant difference between the regressing and growing tumours in PE, PC or GPC content.
Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalNmr in biomedicine
Volume6
Issue number3
DOIs
Publication statusPublished - 1993

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Metabolites
Ablation
Rats
Tumors
Phospholipids
Estrogens
Breast Neoplasms
Glycerylphosphorylcholine
Phosphorylcholine
Neoplasms
S Phase
Methylnitrosourea
Intravenous Administration
Cell Count
DNA

Cite this

Smith, T. A. D., Baluch, S., Titley, J., Eccles, S. A., Leach, M., McReady, R., & Griffiths, J. (1993). The effect of oestrogen-ablation on the phospholipid metabolite content of primary and transplanted rat mammary tumours. Nmr in biomedicine, 6(3), 209-214. https://doi.org/10.1002/nbm.1940060307

The effect of oestrogen-ablation on the phospholipid metabolite content of primary and transplanted rat mammary tumours. / Smith, Timothy Andrew Davies; Baluch, S; Titley, Jenny; Eccles, S A; Leach, Martin ; McReady, Ralph; Griffiths, J.

In: Nmr in biomedicine, Vol. 6, No. 3, 1993, p. 209-214.

Research output: Contribution to journalArticle

Smith, TAD, Baluch, S, Titley, J, Eccles, SA, Leach, M, McReady, R & Griffiths, J 1993, 'The effect of oestrogen-ablation on the phospholipid metabolite content of primary and transplanted rat mammary tumours' Nmr in biomedicine, vol. 6, no. 3, pp. 209-214. https://doi.org/10.1002/nbm.1940060307
Smith, Timothy Andrew Davies ; Baluch, S ; Titley, Jenny ; Eccles, S A ; Leach, Martin ; McReady, Ralph ; Griffiths, J. / The effect of oestrogen-ablation on the phospholipid metabolite content of primary and transplanted rat mammary tumours. In: Nmr in biomedicine. 1993 ; Vol. 6, No. 3. pp. 209-214.
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