The effect of partial removal of the nucleus pulposus from the intervertebral disc on the response of the human annulus fibrosus to compression

Judith Rowena Meakin, Thomas William Redpath, David William Laurence Hukins

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Objective. To determine how partial removal of the nucleus changes the response of the annulus to compression.

Design. The deformation of the annulus in the mid-sagittal plane, during compression, was determined from digital video images.

Background. Several studies have shown that removal of the nucleus changes the external behaviour of the intervertebral disc, but few studies have investigated changes to internal behaviour.

Methods. Six frozen human lumbar discs were bisected in the sagittal plane to produce 12 specimens. The cut surfaces were marked with seven dots of Alcian blue stain. The specimens were sealed, enabling their internal structure to be viewed directly by a digital video recording system, and thawed. The video system recorded the response of each specimen as it was compressed by up to 1.8 mm at a rate of 0.2 mm s(-1). The displacements of the Alcian blue marks were measured using an image analysis program. Magnetic resonance imaging was used to investigate the validity of this technique.

Results. Partial removal of the nucleus changed the way that the disc deformed under compression. A highly significant change in direction of movement was seen in the inner posterior region of the annulus.

Conclusions. Partial removal of the nucleus changes the response of the annulus to compression.

Original languageEnglish
Pages (from-to)121-128
Number of pages7
JournalClinical Biomechanics
Volume16
Issue number2
DOIs
Publication statusPublished - 2001

Keywords

  • discectomy
  • intervertebral disc
  • nucleus pulposus
  • LUMBAR
  • EXTENSION
  • FLEXION
  • SPINE
  • LOADS

Cite this

The effect of partial removal of the nucleus pulposus from the intervertebral disc on the response of the human annulus fibrosus to compression. / Meakin, Judith Rowena; Redpath, Thomas William; Hukins, David William Laurence.

In: Clinical Biomechanics, Vol. 16, No. 2, 2001, p. 121-128.

Research output: Contribution to journalArticle

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abstract = "Objective. To determine how partial removal of the nucleus changes the response of the annulus to compression.Design. The deformation of the annulus in the mid-sagittal plane, during compression, was determined from digital video images.Background. Several studies have shown that removal of the nucleus changes the external behaviour of the intervertebral disc, but few studies have investigated changes to internal behaviour.Methods. Six frozen human lumbar discs were bisected in the sagittal plane to produce 12 specimens. The cut surfaces were marked with seven dots of Alcian blue stain. The specimens were sealed, enabling their internal structure to be viewed directly by a digital video recording system, and thawed. The video system recorded the response of each specimen as it was compressed by up to 1.8 mm at a rate of 0.2 mm s(-1). The displacements of the Alcian blue marks were measured using an image analysis program. Magnetic resonance imaging was used to investigate the validity of this technique.Results. Partial removal of the nucleus changed the way that the disc deformed under compression. A highly significant change in direction of movement was seen in the inner posterior region of the annulus.Conclusions. Partial removal of the nucleus changes the response of the annulus to compression.",
keywords = "discectomy, intervertebral disc, nucleus pulposus, LUMBAR, EXTENSION, FLEXION, SPINE, LOADS",
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T1 - The effect of partial removal of the nucleus pulposus from the intervertebral disc on the response of the human annulus fibrosus to compression

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AU - Redpath, Thomas William

AU - Hukins, David William Laurence

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N2 - Objective. To determine how partial removal of the nucleus changes the response of the annulus to compression.Design. The deformation of the annulus in the mid-sagittal plane, during compression, was determined from digital video images.Background. Several studies have shown that removal of the nucleus changes the external behaviour of the intervertebral disc, but few studies have investigated changes to internal behaviour.Methods. Six frozen human lumbar discs were bisected in the sagittal plane to produce 12 specimens. The cut surfaces were marked with seven dots of Alcian blue stain. The specimens were sealed, enabling their internal structure to be viewed directly by a digital video recording system, and thawed. The video system recorded the response of each specimen as it was compressed by up to 1.8 mm at a rate of 0.2 mm s(-1). The displacements of the Alcian blue marks were measured using an image analysis program. Magnetic resonance imaging was used to investigate the validity of this technique.Results. Partial removal of the nucleus changed the way that the disc deformed under compression. A highly significant change in direction of movement was seen in the inner posterior region of the annulus.Conclusions. Partial removal of the nucleus changes the response of the annulus to compression.

AB - Objective. To determine how partial removal of the nucleus changes the response of the annulus to compression.Design. The deformation of the annulus in the mid-sagittal plane, during compression, was determined from digital video images.Background. Several studies have shown that removal of the nucleus changes the external behaviour of the intervertebral disc, but few studies have investigated changes to internal behaviour.Methods. Six frozen human lumbar discs were bisected in the sagittal plane to produce 12 specimens. The cut surfaces were marked with seven dots of Alcian blue stain. The specimens were sealed, enabling their internal structure to be viewed directly by a digital video recording system, and thawed. The video system recorded the response of each specimen as it was compressed by up to 1.8 mm at a rate of 0.2 mm s(-1). The displacements of the Alcian blue marks were measured using an image analysis program. Magnetic resonance imaging was used to investigate the validity of this technique.Results. Partial removal of the nucleus changed the way that the disc deformed under compression. A highly significant change in direction of movement was seen in the inner posterior region of the annulus.Conclusions. Partial removal of the nucleus changes the response of the annulus to compression.

KW - discectomy

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KW - nucleus pulposus

KW - LUMBAR

KW - EXTENSION

KW - FLEXION

KW - SPINE

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