The Effect of Sodium Acetate Ingestion on the Metabolic Response to Prolonged Moderate-Intensity Exercise in Humans

Gordon I. Smith, Asker E. Jeukendrup, Derek Ball

Research output: Contribution to journalArticle

Abstract

At rest, administration of the short-chain fatty acid acetate suppresses fat oxidation without affecting carbohydrate utilization. The combined effect of increased acetate availability and exercise on substrate utilization is, however, unclear. With local ethics approval, we studied the effect of ingesting either sodium acetate (NaAc) or sodium bicarbonate (NaHCO3) at a dose of 4 mmol·kg-1 body mass 90 min before completing 120 min of exercise at 50% VO2peak. Six healthy young men completed the trials after an overnight fast and ingested the sodium salts in randomized order. As expected NaAc ingestion decreased resting fat oxidation (mean ± SD; 0.09 ± 0.02 vs. 0.07 ± 0.02 g·min-1 pre- and post-ingestion respectively, p < .05) with no effect upon carbohydrate utilization. In contrast, NaHCO3 ingestion had no effect on substrate utilization at rest. In response to exercise, fat and CHO oxidation increased in both trials, but fat oxidation was lower (0.16 ± 0.10 vs. 0.29 ± 0.11 g·min -1, p < .05) and carbohydrate oxidation higher (1.67 ± 0.35 vs. 1.44 ± 0.22 g·min-1, p < .05) in the NaAc trial compared with the NaHCO3 trial during the first 15 min of exercise. Over the final 75 min of exercise an increase in fat oxidation and decrease in carbohydrate oxidation was observed only in the NaAc trial. These results demonstrate that increasing plasma acetate concentration suppresses fat oxidation both at rest and at the onset of moderate-intensity exercise.

Original languageEnglish
Pages (from-to)357-368
Number of pages12
JournalInternational Journal of Sport Nutrition and Exercise Metabolism
Volume23
Issue number4
DOIs
Publication statusPublished - 2013

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Sodium Acetate
sodium acetate
exercise
Eating
Fats
ingestion
Exercise
oxidation
Carbohydrates
Acetates
lipids
carbohydrates
acetates
Sodium Bicarbonate
Volatile Fatty Acids
Ethics
sodium bicarbonate
ethics
short chain fatty acids
Salts

Keywords

  • Acetyl availability
  • Sodium salt
  • Substrate oxidation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Orthopedics and Sports Medicine
  • Nutrition and Dietetics

Cite this

The Effect of Sodium Acetate Ingestion on the Metabolic Response to Prolonged Moderate-Intensity Exercise in Humans. / Smith, Gordon I.; Jeukendrup, Asker E.; Ball, Derek.

In: International Journal of Sport Nutrition and Exercise Metabolism, Vol. 23, No. 4, 2013, p. 357-368.

Research output: Contribution to journalArticle

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