The gut microbiota, bacterial metabolites and colorectal cancer

Petra Louis; Georgina L. Hold; Harry J. Flint

doi:10.1038/nrmicro3344

The gut microbiota, bacterial metabolites and colorectal cancer

Petra Louis, Georgina L. Hold, Harry J. Flint^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

1858 Citations (Scopus)

Abstract

Accumulating evidence suggests that the human intestinal microbiota contributes to the aetiology of colorectal cancer (CRC), not only via the pro-carcinogenic activities of specific pathogens but also via the influence of the wider microbial community, particularly its metabolome. Recent data have shown that the short-chain fatty acids acetate, propionate and butyrate function in the suppression of inflammation and cancer, whereas other microbial metabolites, such as secondary bile acids, promote carcinogenesis. In this Review, we discuss the relationship between diet, microbial metabolism and CRC and argue that the cumulative effects of microbial metabolites should be considered in order to better predict and prevent cancer progression.

Original language	English
Pages (from-to)	661-672
Number of pages	12
Journal	Nature Reviews Microbiology
Volume	12
Issue number	10
Early online date	8 Sept 2014
DOIs	https://doi.org/10.1038/nrmicro3344
Publication status	Published - Oct 2014

Bibliographical note

P.L. and H.F. acknowledge support from the Scottish Government Food Land and People programme. The authors thank A. Walker and R. Barker for critical reading of the manuscript.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrmicro3344

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title = "The gut microbiota, bacterial metabolites and colorectal cancer",

abstract = "Accumulating evidence suggests that the human intestinal microbiota contributes to the aetiology of colorectal cancer (CRC), not only via the pro-carcinogenic activities of specific pathogens but also via the influence of the wider microbial community, particularly its metabolome. Recent data have shown that the short-chain fatty acids acetate, propionate and butyrate function in the suppression of inflammation and cancer, whereas other microbial metabolites, such as secondary bile acids, promote carcinogenesis. In this Review, we discuss the relationship between diet, microbial metabolism and CRC and argue that the cumulative effects of microbial metabolites should be considered in order to better predict and prevent cancer progression.",

author = "Petra Louis and Hold, {Georgina L.} and Flint, {Harry J.}",

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AU - Louis, Petra

AU - Hold, Georgina L.

AU - Flint, Harry J.

N1 - P.L. and H.F. acknowledge support from the Scottish Government Food Land and People programme. The authors thank A. Walker and R. Barker for critical reading of the manuscript.

PY - 2014/10

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N2 - Accumulating evidence suggests that the human intestinal microbiota contributes to the aetiology of colorectal cancer (CRC), not only via the pro-carcinogenic activities of specific pathogens but also via the influence of the wider microbial community, particularly its metabolome. Recent data have shown that the short-chain fatty acids acetate, propionate and butyrate function in the suppression of inflammation and cancer, whereas other microbial metabolites, such as secondary bile acids, promote carcinogenesis. In this Review, we discuss the relationship between diet, microbial metabolism and CRC and argue that the cumulative effects of microbial metabolites should be considered in order to better predict and prevent cancer progression.

AB - Accumulating evidence suggests that the human intestinal microbiota contributes to the aetiology of colorectal cancer (CRC), not only via the pro-carcinogenic activities of specific pathogens but also via the influence of the wider microbial community, particularly its metabolome. Recent data have shown that the short-chain fatty acids acetate, propionate and butyrate function in the suppression of inflammation and cancer, whereas other microbial metabolites, such as secondary bile acids, promote carcinogenesis. In this Review, we discuss the relationship between diet, microbial metabolism and CRC and argue that the cumulative effects of microbial metabolites should be considered in order to better predict and prevent cancer progression.

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JF - Nature Reviews Microbiology

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The gut microbiota, bacterial metabolites and colorectal cancer

Abstract

Bibliographical note

UN SDGs

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