The impact of female obesity on the outcome of fertility treatment

Shilpi Pandey, Suruchi Pandey, Abha Maheshwari, Siladitya Bhattacharya

Research output: Contribution to journalArticle

58 Citations (Scopus)
6 Downloads (Pure)

Abstract

The rising prevalence of obesity has had a profound impact on female reproductive health. Increased body mass index (BMI) is associated with ovulatory subfertility and anovulatory infertility. Overweight and obese women have poorer outcomes following fertility treatment. They respond poorly to clomiphene induction of ovulation and require higher doses of gonadotrophins for ovulation induction and superovulation. Ovarian stimulation for assisted reproduction produces fewer follicles resulting in the harvest of fewer oocytes. Fertilization rates are poorer and the embryo quality is impaired in younger women who are
obese. Pregnancy rate in some studies is lower and there is an increased risk of early pregnancy loss. Weight loss regularizes menstrual cycles and increases the chance of spontaneous ovulation and conception in anovulatory overweight and obese women. Gradual sustained weight loss is beneficial whereas crash
dieting is detrimental.
Original languageEnglish
Pages (from-to)62-67
Number of pages6
JournalJournal of Human Reproductive Sciences
Volume3
Issue number2
DOIs
Publication statusPublished - May 2010

Fingerprint

Ovulation Induction
Fertility
Obesity
Infertility
Weight Loss
Superovulation
Clomiphene
Reproductive Health
Pregnancy Rate
Menstrual Cycle
Ovulation
Gonadotropins
Fertilization
Oocytes
Reproduction
Body Mass Index
Embryonic Structures
Pregnancy
Therapeutics

Keywords

  • assisted reproduction
  • obesity
  • fertility treatment

Cite this

The impact of female obesity on the outcome of fertility treatment. / Pandey, Shilpi; Pandey, Suruchi; Maheshwari, Abha; Bhattacharya, Siladitya.

In: Journal of Human Reproductive Sciences, Vol. 3, No. 2, 05.2010, p. 62-67.

Research output: Contribution to journalArticle

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