The importance of the aggregation of ticks on small mammal hosts for the establishment and persistence of tick-borne pathogens: an investigation using the R(0) model

Alan Harrison, Nigel C Bennett

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Aggregation of parasites amongst hosts is important for the epidemiology of vector-borne diseases because hosts that support the majority of the vector population are responsible for the majority of pathogen transmission. Ixodes ricinus ticks transmit numerous pathogens of medical importance including Borrelia burgdorferi s.l. and tick-borne encephalitis virus. One transmission route involved is 'co-feeding transmission', where larvae become infected via feeding alongside infected nymphs. The aggregation of ticks on hosts leads to an increase in the number of larvae feeding alongside nymphs, increasing the transmission potential via this route. The basic reproduction number, R 0, can be used to identify whether a pathogen will become established if introduced. In the current study we use previously published tick, and pathogen, specific data to parameterize an R 0 model to investigate how the degree of aggregation of ticks on hosts affects pathogen persistence. The coincident aggregated distribution permitted the establishment of tick-borne encephalitis virus but did not influence whether B. burgdorferi s.l. became established. The relationship between the k-exponent of the negative binomial distribution and R 0 was also defined. Therefore, the degree of aggregation of ticks on small mammal hosts has important implications for the risk to human health in a given area.
Original languageEnglish
Pages (from-to)1605-1613
Number of pages9
JournalParasitology
Volume139
Issue number12
Early online date19 Jul 2012
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Ticks
small mammals
ticks
Mammals
pathogens
Tick-borne encephalitis virus
Tick-Borne Encephalitis Viruses
Nymph
Borrelia burgdorferi
nymphs
Larva
Basic Reproduction Number
Binomial Distribution
Disease Vectors
vector-borne diseases
Ixodes
Ixodes ricinus
Infectious Disease Transmission
larvae
human health

Keywords

  • vector-borne diseases
  • aggregation
  • transmission
  • Ixodes ricinus
  • borrelia-burgdorferi.I.
  • epidemiology

Cite this

The importance of the aggregation of ticks on small mammal hosts for the establishment and persistence of tick-borne pathogens : an investigation using the R(0) model. / Harrison, Alan; Bennett, Nigel C.

In: Parasitology, Vol. 139, No. 12, 10.2012, p. 1605-1613.

Research output: Contribution to journalArticle

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