The influence of diet on the gut microbiota

Research output: Contribution to journalLiterature review

360 Citations (Scopus)

Abstract

Diet is a major factor driving the composition and metabolism of the colonic microbiota. The amount, type and balance of the main dietary macronutrients (carbohydrates, proteins and fats) have a great impact on the large intestinal microbiota. The human colon contains a dense population of bacterial cells that outnumber host cells 10-fold. Bacteroidetes, Firmicutes and Actinobacteria are the three major phyla that inhabit the human large intestine and these bacteria possess a fascinating array of enzymes that can degrade complex dietary substrates. Certain colonic bacteria are able to metabolise a remarkable variety of substrates whilst other species carry out more specialised activities, including primary degradation of plant cell walls. Microbial metabolism of dietary carbohydrates results mainly in the formation of short chain fatty acids and gases. The major bacterial fermentation products are acetate, propionate and butyrate; and the production of these tends to lower the colonic pH. These weak acids influence the microbial composition and directly affect host health, with butyrate the preferred energy source for the colonocytes. Certain bacterial species in the colon survive by cross-feeding, using either the breakdown products of complex carbohydrate degradation or fermentation products such as lactic acid for growth. Microbial protein metabolism results in additional fermentation products, some of which are potentially harmful to host health. The current 'omic era promises rapid progress towards understanding how diet can be used to modulate the composition and metabolism of the gut microbiota, allowing researchers to provide informed advice, that should improve long-term health status.
Original languageEnglish
Pages (from-to)52-60
Number of pages9
JournalPharmacological Research
Volume69
Issue number1
Early online date9 Nov 2012
DOIs
Publication statusPublished - Mar 2013

Fingerprint

Diet
Fermentation
Dietary Carbohydrates
Butyrates
Colon
Bacteroidetes
Bacteria
Volatile Fatty Acids
Actinobacteria
Dietary Fats
Microbiota
Large Intestine
Propionates
Health
Plant Cells
Cell Wall
Health Status
Lactic Acid
Proteins
Acetates

Keywords

  • firmicutes
  • gut microbiota
  • diet
  • carbohydrates
  • prebiotics
  • protein
  • health

Cite this

The influence of diet on the gut microbiota. / Scott, Karen P; Gratz, Silvia W; Sheridan, Paul O; Flint, Harry J; Duncan, Sylvia H.

In: Pharmacological Research, Vol. 69, No. 1, 03.2013, p. 52-60.

Research output: Contribution to journalLiterature review

@article{2f6ad5ef4141493e864c7330fcb861a8,
title = "The influence of diet on the gut microbiota",
abstract = "Diet is a major factor driving the composition and metabolism of the colonic microbiota. The amount, type and balance of the main dietary macronutrients (carbohydrates, proteins and fats) have a great impact on the large intestinal microbiota. The human colon contains a dense population of bacterial cells that outnumber host cells 10-fold. Bacteroidetes, Firmicutes and Actinobacteria are the three major phyla that inhabit the human large intestine and these bacteria possess a fascinating array of enzymes that can degrade complex dietary substrates. Certain colonic bacteria are able to metabolise a remarkable variety of substrates whilst other species carry out more specialised activities, including primary degradation of plant cell walls. Microbial metabolism of dietary carbohydrates results mainly in the formation of short chain fatty acids and gases. The major bacterial fermentation products are acetate, propionate and butyrate; and the production of these tends to lower the colonic pH. These weak acids influence the microbial composition and directly affect host health, with butyrate the preferred energy source for the colonocytes. Certain bacterial species in the colon survive by cross-feeding, using either the breakdown products of complex carbohydrate degradation or fermentation products such as lactic acid for growth. Microbial protein metabolism results in additional fermentation products, some of which are potentially harmful to host health. The current 'omic era promises rapid progress towards understanding how diet can be used to modulate the composition and metabolism of the gut microbiota, allowing researchers to provide informed advice, that should improve long-term health status.",
keywords = "firmicutes, gut microbiota, diet , carbohydrates, prebiotics, protein , health",
author = "Scott, {Karen P} and Gratz, {Silvia W} and Sheridan, {Paul O} and Flint, {Harry J} and Duncan, {Sylvia H}",
note = "Copyright {\circledC} 2012 Elsevier Ltd. All rights reserved.",
year = "2013",
month = "3",
doi = "10.1016/j.phrs.2012.10.020",
language = "English",
volume = "69",
pages = "52--60",
journal = "Pharmacological Research",
issn = "1043-6618",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - The influence of diet on the gut microbiota

AU - Scott, Karen P

AU - Gratz, Silvia W

AU - Sheridan, Paul O

AU - Flint, Harry J

AU - Duncan, Sylvia H

N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.

PY - 2013/3

Y1 - 2013/3

N2 - Diet is a major factor driving the composition and metabolism of the colonic microbiota. The amount, type and balance of the main dietary macronutrients (carbohydrates, proteins and fats) have a great impact on the large intestinal microbiota. The human colon contains a dense population of bacterial cells that outnumber host cells 10-fold. Bacteroidetes, Firmicutes and Actinobacteria are the three major phyla that inhabit the human large intestine and these bacteria possess a fascinating array of enzymes that can degrade complex dietary substrates. Certain colonic bacteria are able to metabolise a remarkable variety of substrates whilst other species carry out more specialised activities, including primary degradation of plant cell walls. Microbial metabolism of dietary carbohydrates results mainly in the formation of short chain fatty acids and gases. The major bacterial fermentation products are acetate, propionate and butyrate; and the production of these tends to lower the colonic pH. These weak acids influence the microbial composition and directly affect host health, with butyrate the preferred energy source for the colonocytes. Certain bacterial species in the colon survive by cross-feeding, using either the breakdown products of complex carbohydrate degradation or fermentation products such as lactic acid for growth. Microbial protein metabolism results in additional fermentation products, some of which are potentially harmful to host health. The current 'omic era promises rapid progress towards understanding how diet can be used to modulate the composition and metabolism of the gut microbiota, allowing researchers to provide informed advice, that should improve long-term health status.

AB - Diet is a major factor driving the composition and metabolism of the colonic microbiota. The amount, type and balance of the main dietary macronutrients (carbohydrates, proteins and fats) have a great impact on the large intestinal microbiota. The human colon contains a dense population of bacterial cells that outnumber host cells 10-fold. Bacteroidetes, Firmicutes and Actinobacteria are the three major phyla that inhabit the human large intestine and these bacteria possess a fascinating array of enzymes that can degrade complex dietary substrates. Certain colonic bacteria are able to metabolise a remarkable variety of substrates whilst other species carry out more specialised activities, including primary degradation of plant cell walls. Microbial metabolism of dietary carbohydrates results mainly in the formation of short chain fatty acids and gases. The major bacterial fermentation products are acetate, propionate and butyrate; and the production of these tends to lower the colonic pH. These weak acids influence the microbial composition and directly affect host health, with butyrate the preferred energy source for the colonocytes. Certain bacterial species in the colon survive by cross-feeding, using either the breakdown products of complex carbohydrate degradation or fermentation products such as lactic acid for growth. Microbial protein metabolism results in additional fermentation products, some of which are potentially harmful to host health. The current 'omic era promises rapid progress towards understanding how diet can be used to modulate the composition and metabolism of the gut microbiota, allowing researchers to provide informed advice, that should improve long-term health status.

KW - firmicutes

KW - gut microbiota

KW - diet

KW - carbohydrates

KW - prebiotics

KW - protein

KW - health

U2 - 10.1016/j.phrs.2012.10.020

DO - 10.1016/j.phrs.2012.10.020

M3 - Literature review

VL - 69

SP - 52

EP - 60

JO - Pharmacological Research

JF - Pharmacological Research

SN - 1043-6618

IS - 1

ER -