TY - JOUR
T1 - The lipoprotein lipase S447X and cholesteryl ester transfer protein rs5882 polymorphisms and their relationship with lipid profile in human serum of obese individuals
AU - Emamian, Marzieh
AU - Avan, Amir
AU - Pasdar, Alireza
AU - Mirhafez, Seyed Reza
AU - Sadeghzadeh, Mahsa
AU - Moghadam, Masoud Saleh
AU - Parizadeh, Seyed Mohammad Reza
AU - Ferns, Gordon A.
AU - Ghayour-Mobarhan, Majid
N1 - This study was support by grant from Mashhad University of Medical Sciences.
PY - 2015/3/10
Y1 - 2015/3/10
N2 - Background: Obesity is often associated with an alter lipid profile, e.g., raised serum triglycerides (TG) and low high-density lipoprotein (HDL) cholesterol levels, both important risk factor for cardiovascular-diseases. The aim of current study was to explore the association of a polymorphism of the lipoprotein lipase (LPL) rs328 and cholesteryl-ester-transfer-protein (CETP) rs5882 genes in relation to lipid profile in subjects with/without obesity. Subjects/methods: Genotyping was carried out in 271 individuals, (151 obese subjects and 120 non-obese). Univariate/multivariate analyses were conducted to evaluate the association of these genetic-polymorphisms with obesity and lipid components. Results: Obese subjects had a significantly (P. <. 0.05) higher level of triglyceride (TG), blood pressure, waist-circumference and fasting-blood-glucose, and lower level of HDL-C. LPL and CETP polymorphisms were not associated with obesity in our population. However, the LPL rs328-GG-GC genotype was significantly related to a higher concentration of TG, compared to the CC wild-type; and a higher HDL-C level in the obesity-group with respect to the control group. Moreover, obese-subjects carrying the G allele of CETP had a significantly lower level of HDL-C (P. <. 0.05) compared to those with C allele. Conclusion: We demonstrate a significant association of LPL and CETP polymorphisms with serum triglycerides and HDL-cholesterol.
AB - Background: Obesity is often associated with an alter lipid profile, e.g., raised serum triglycerides (TG) and low high-density lipoprotein (HDL) cholesterol levels, both important risk factor for cardiovascular-diseases. The aim of current study was to explore the association of a polymorphism of the lipoprotein lipase (LPL) rs328 and cholesteryl-ester-transfer-protein (CETP) rs5882 genes in relation to lipid profile in subjects with/without obesity. Subjects/methods: Genotyping was carried out in 271 individuals, (151 obese subjects and 120 non-obese). Univariate/multivariate analyses were conducted to evaluate the association of these genetic-polymorphisms with obesity and lipid components. Results: Obese subjects had a significantly (P. <. 0.05) higher level of triglyceride (TG), blood pressure, waist-circumference and fasting-blood-glucose, and lower level of HDL-C. LPL and CETP polymorphisms were not associated with obesity in our population. However, the LPL rs328-GG-GC genotype was significantly related to a higher concentration of TG, compared to the CC wild-type; and a higher HDL-C level in the obesity-group with respect to the control group. Moreover, obese-subjects carrying the G allele of CETP had a significantly lower level of HDL-C (P. <. 0.05) compared to those with C allele. Conclusion: We demonstrate a significant association of LPL and CETP polymorphisms with serum triglycerides and HDL-cholesterol.
KW - CETP
KW - Lipid metabolism
KW - LPL
KW - Obese subjects
UR - http://www.scopus.com/inward/record.url?scp=84922168141&partnerID=8YFLogxK
U2 - 10.1016/j.gene.2014.12.070
DO - 10.1016/j.gene.2014.12.070
M3 - Article
C2 - 25579610
AN - SCOPUS:84922168141
VL - 558
SP - 195
EP - 199
JO - Gene
JF - Gene
SN - 0378-1119
IS - 2
ER -
