The lipoprotein lipase S447X and cholesteryl ester transfer protein rs5882 polymorphisms and their relationship with lipid profile in human serum of obese individuals

Marzieh Emamian, Amir Avan, Alireza Pasdar, Seyed Reza Mirhafez, Mahsa Sadeghzadeh, Masoud Saleh Moghadam, Seyed Mohammad Reza Parizadeh, Gordon A. Ferns, Majid Ghayour-Mobarhan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Background: Obesity is often associated with an alter lipid profile, e.g., raised serum triglycerides (TG) and low high-density lipoprotein (HDL) cholesterol levels, both important risk factor for cardiovascular-diseases. The aim of current study was to explore the association of a polymorphism of the lipoprotein lipase (LPL) rs328 and cholesteryl-ester-transfer-protein (CETP) rs5882 genes in relation to lipid profile in subjects with/without obesity. Subjects/methods: Genotyping was carried out in 271 individuals, (151 obese subjects and 120 non-obese). Univariate/multivariate analyses were conducted to evaluate the association of these genetic-polymorphisms with obesity and lipid components. Results: Obese subjects had a significantly (P. <. 0.05) higher level of triglyceride (TG), blood pressure, waist-circumference and fasting-blood-glucose, and lower level of HDL-C. LPL and CETP polymorphisms were not associated with obesity in our population. However, the LPL rs328-GG-GC genotype was significantly related to a higher concentration of TG, compared to the CC wild-type; and a higher HDL-C level in the obesity-group with respect to the control group. Moreover, obese-subjects carrying the G allele of CETP had a significantly lower level of HDL-C (P. <. 0.05) compared to those with C allele. Conclusion: We demonstrate a significant association of LPL and CETP polymorphisms with serum triglycerides and HDL-cholesterol.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalGene
Volume558
Issue number2
DOIs
Publication statusPublished - 10 Mar 2015

Keywords

  • CETP
  • Lipid metabolism
  • LPL
  • Obese subjects

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