The measurement of fetal liver T2* in utero before and after maternal oxygen breathing: progress toward a non-invasive measurement of fetal oxygenation and placental function

Scott Ian Kay Semple, F. Wallis, Paul Haggarty, David Abramovich, John A S Ross, Thomas William Redpath, Fiona Jane Gilbert

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31 Citations (Scopus)

Abstract

Utero-placental insufficiency is thought to be a major cause of growth retardation in utero and an important risk factor in the perinatal period. The purpose of this study was to investigate whether MRI could detect changes of fetal oxygenation, based on the blood oxygenation level dependence (BOLD) of the MRI tissue signal. Nine third trimester women (34-38 weeks) with normal pregnancies underwent abdominal MRI examinations. Following localization of the fetal liver using T-2-weighted single-shot HASTE scans, up to 7 breath-held transaxial single-slice gradient-echo image sets were obtained through the fetal liver. The mother then commenced oxygen breathing with the imaging procedure repeated after 20 minutes of O-2 breathing. For each image set, T-2(*) values are calculated using linear regression of log (signal) versus TE for a region of interest within the fetal liver selected by the attending radiologist. Fetal liver T-2(*) values were calculated before and after O-2 breathing for each multi-echo image acquisition set. A signed rank test was used to test for a significant change in fetal liver T-2(*) between the pre-O-2 and post-O-2 image sets. A significant increase in T-2(*) (alpha < 0.05) was seen in 5 of the 9 fetal livers, a smaller increase (of borderline statistical significance, alpha = 0.057) in 2 livers, and no significant change (alpha > 0.05) in 2 livers. Our study indicates that T-2(*) measurement of the fetal liver may detect alteration in fetal oxygen level following maternal oxygenation using the BOLD effect. This technique may potentially be applied to the identification and understanding of placental dysfunction in intra-uterine growth retardation. (C) 2001 Elsevier Science Inc. All rights reserved.

Original languageEnglish
Pages (from-to)921-928
Number of pages7
JournalMagnetic Resonance Imaging
Volume19
DOIs
Publication statusPublished - 2001

Keywords

  • magnetic resonance imaging
  • BOLD effect
  • fetal oxygenation
  • placenta
  • intrauterine growth retardation (IUGR)
  • BLOOD
  • DEPENDENCE
  • FIELD

Cite this

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title = "The measurement of fetal liver T2* in utero before and after maternal oxygen breathing: progress toward a non-invasive measurement of fetal oxygenation and placental function",
abstract = "Utero-placental insufficiency is thought to be a major cause of growth retardation in utero and an important risk factor in the perinatal period. The purpose of this study was to investigate whether MRI could detect changes of fetal oxygenation, based on the blood oxygenation level dependence (BOLD) of the MRI tissue signal. Nine third trimester women (34-38 weeks) with normal pregnancies underwent abdominal MRI examinations. Following localization of the fetal liver using T-2-weighted single-shot HASTE scans, up to 7 breath-held transaxial single-slice gradient-echo image sets were obtained through the fetal liver. The mother then commenced oxygen breathing with the imaging procedure repeated after 20 minutes of O-2 breathing. For each image set, T-2(*) values are calculated using linear regression of log (signal) versus TE for a region of interest within the fetal liver selected by the attending radiologist. Fetal liver T-2(*) values were calculated before and after O-2 breathing for each multi-echo image acquisition set. A signed rank test was used to test for a significant change in fetal liver T-2(*) between the pre-O-2 and post-O-2 image sets. A significant increase in T-2(*) (alpha < 0.05) was seen in 5 of the 9 fetal livers, a smaller increase (of borderline statistical significance, alpha = 0.057) in 2 livers, and no significant change (alpha > 0.05) in 2 livers. Our study indicates that T-2(*) measurement of the fetal liver may detect alteration in fetal oxygen level following maternal oxygenation using the BOLD effect. This technique may potentially be applied to the identification and understanding of placental dysfunction in intra-uterine growth retardation. (C) 2001 Elsevier Science Inc. All rights reserved.",
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author = "Semple, {Scott Ian Kay} and F. Wallis and Paul Haggarty and David Abramovich and Ross, {John A S} and Redpath, {Thomas William} and Gilbert, {Fiona Jane}",
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TY - JOUR

T1 - The measurement of fetal liver T2* in utero before and after maternal oxygen breathing: progress toward a non-invasive measurement of fetal oxygenation and placental function

AU - Semple, Scott Ian Kay

AU - Wallis, F.

AU - Haggarty, Paul

AU - Abramovich, David

AU - Ross, John A S

AU - Redpath, Thomas William

AU - Gilbert, Fiona Jane

PY - 2001

Y1 - 2001

N2 - Utero-placental insufficiency is thought to be a major cause of growth retardation in utero and an important risk factor in the perinatal period. The purpose of this study was to investigate whether MRI could detect changes of fetal oxygenation, based on the blood oxygenation level dependence (BOLD) of the MRI tissue signal. Nine third trimester women (34-38 weeks) with normal pregnancies underwent abdominal MRI examinations. Following localization of the fetal liver using T-2-weighted single-shot HASTE scans, up to 7 breath-held transaxial single-slice gradient-echo image sets were obtained through the fetal liver. The mother then commenced oxygen breathing with the imaging procedure repeated after 20 minutes of O-2 breathing. For each image set, T-2(*) values are calculated using linear regression of log (signal) versus TE for a region of interest within the fetal liver selected by the attending radiologist. Fetal liver T-2(*) values were calculated before and after O-2 breathing for each multi-echo image acquisition set. A signed rank test was used to test for a significant change in fetal liver T-2(*) between the pre-O-2 and post-O-2 image sets. A significant increase in T-2(*) (alpha < 0.05) was seen in 5 of the 9 fetal livers, a smaller increase (of borderline statistical significance, alpha = 0.057) in 2 livers, and no significant change (alpha > 0.05) in 2 livers. Our study indicates that T-2(*) measurement of the fetal liver may detect alteration in fetal oxygen level following maternal oxygenation using the BOLD effect. This technique may potentially be applied to the identification and understanding of placental dysfunction in intra-uterine growth retardation. (C) 2001 Elsevier Science Inc. All rights reserved.

AB - Utero-placental insufficiency is thought to be a major cause of growth retardation in utero and an important risk factor in the perinatal period. The purpose of this study was to investigate whether MRI could detect changes of fetal oxygenation, based on the blood oxygenation level dependence (BOLD) of the MRI tissue signal. Nine third trimester women (34-38 weeks) with normal pregnancies underwent abdominal MRI examinations. Following localization of the fetal liver using T-2-weighted single-shot HASTE scans, up to 7 breath-held transaxial single-slice gradient-echo image sets were obtained through the fetal liver. The mother then commenced oxygen breathing with the imaging procedure repeated after 20 minutes of O-2 breathing. For each image set, T-2(*) values are calculated using linear regression of log (signal) versus TE for a region of interest within the fetal liver selected by the attending radiologist. Fetal liver T-2(*) values were calculated before and after O-2 breathing for each multi-echo image acquisition set. A signed rank test was used to test for a significant change in fetal liver T-2(*) between the pre-O-2 and post-O-2 image sets. A significant increase in T-2(*) (alpha < 0.05) was seen in 5 of the 9 fetal livers, a smaller increase (of borderline statistical significance, alpha = 0.057) in 2 livers, and no significant change (alpha > 0.05) in 2 livers. Our study indicates that T-2(*) measurement of the fetal liver may detect alteration in fetal oxygen level following maternal oxygenation using the BOLD effect. This technique may potentially be applied to the identification and understanding of placental dysfunction in intra-uterine growth retardation. (C) 2001 Elsevier Science Inc. All rights reserved.

KW - magnetic resonance imaging

KW - BOLD effect

KW - fetal oxygenation

KW - placenta

KW - intrauterine growth retardation (IUGR)

KW - BLOOD

KW - DEPENDENCE

KW - FIELD

U2 - 10.1016/S0730-725X(01)00421-0

DO - 10.1016/S0730-725X(01)00421-0

M3 - Article

VL - 19

SP - 921

EP - 928

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

ER -